I'm with pain and kubes on the NAC, pretty much a staple. If I'm really beating on my liver I'll throw in some tudca at 500mg/day. Never been a fan of the all in one support sups. Seems expensive and half the time they don't even give adequate amounts of the ingredients to be effective. Its not to say there aren't decent ones, I believe there is. I just prefer to control my doses without buying a lot of fillers. As far as the bp support supps in them, one word, CARDIO. Its cheap and amazingly effective, at least for me. I'm talking about a 20 point drop of both numbers.