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    Thread: Jet Injection (Sub-Q) NEEDLE-FREE SUBCUTANEOUS SELF INJECTION FOR TESTOSTERONE

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      Jet Injection (Sub-Q) NEEDLE-FREE SUBCUTANEOUS SELF INJECTION FOR TESTOSTERONE

      Jet injection device for the needle-free administration of compounds, vaccines, and other agents.

      "NEEDLE-FREE SUBCUTANEOUS SELF INJECTION FOR TESTOSTERONE SUPPLEMENTATION THERAPY"


      I've heard of this method of administration being utilized at some specialists and clinics,but rather more for vaccines and numbing agents (mostly on children and the elderly), but the possibles here seem endless when it pertains to HGH/PEPTIDES, TRT administration (Test Cyp/Test E) or even the possibility of Test-suspension, TNE, Winstrol and Tren Base for pre-workout..

      After watching the demonstration in the preparation video, it's fair to say it's really not to much of a fuss when compared to changing drawing pins and needle tips..This is actually not NEW technology and has been around for decades...Interesting to say the least!

      Below is a study that was conducted with positive serum results, also including pictures of the system and a demonstration video with the set-up for preparation utilizing different compounds,and agents..

      Your thoughts,please share!

      Vision
      __________________________________________________ _____



      NEEDLE-FREE SUBCUTANEOUS SELF INJECTION FOR TESTOSTERONE SUPPLEMENTATION THERAPY


      Abstract: PD37-06
      Date & Time:
      Session Title: Sexual Function/Dysfunction/Andrology: Medical and Non-Surgical Therapy I
      Sources of Funding: Bioject, Inc

      Introductions and Objectives
      Various modalities for testosterone supplementation therapy (TST) are in wide use with an increasing frequency. Each has unique disadvantages with regard to fluctuating testosterone (T) levels, pain, or potential for unintentional topical transfer. While IM testosterone cypionate (Tc) has an abundance of clinical experience, subcutaneous (sc) injections of Tc has not been adequately studied. Similarly, needle-free therapy has not been evaluated as an option despite decades of use. We investigated the feasibility, pharmacokinetics, and efficacy of self administered needle-free sc injection of Tc as a viable treatment for TST. We hypothesized that needle-free delivery of TST would reach efficacious T levels, be well tolerated, improve symptoms and be self administered with negligible pain.

      Methods
      Informed consent and IRB approval was obtained to enroll 24 symptomatic hypogonadal men in two consecutive proof-of-concept prospective studies. In the first 30 days, 14 men injected 25mg/day (QD25) and 10 men injected 50mg Monday, Wednesday, and Friday with weekends off (MWFWO50). Serum T levels were obtained at close intervals to determine both optimal Tc dose and injection frequency. In the second study, data was combined from QODWO50 dosing at Day 60 and Day 90. Validated pain scores and the Aging Male Symptom (AMS) score were recorded Day 0 and Day 30.

      Results
      Twenty-four total hypogonadal men enrolled in the studies with an average T level of 171ng/dL. Phase I of the study demonstrated therapeutic levels in all men both QD25 and MWFWO50 dosing by Day 14. Mean T levels at Day 30 for QD25 and QODWO50 dosing was 846ng/dL and 585ng/dL, respectively. Four of 14 QD25 men were supraphysiologic at Day 30. To mitigate this observed trend of rising T levels 10 men from the Phase I QD25 cohort were converted to QODWO50 at Day 30. All men in the QODWO50 program were eugonadal at Day 60 (616ng/mL ± SD 179) and 90 (586ng/mL ± SD 159). In addition, (20/20) men had statistically significant improvement in AMS score and reported minimal pain (p≤0.001). Estrodiol and free/total T levels increased in accordance with historically published Tc IM treatments. No adverse events occurred.

      Conclusions
      Needle-free delivery of commercially available testosterone cypionate is efficacious and provides physiologic ranges of T serum levels in men whom self inject subcutaneously three times weekly with 50mg. The benefits of flexible dosing, self administration, maintenance of more consistent T serum levels, minimal pain, and reduced risk of interpersonal transfer makes this novel approach worth evaluating on a larger scale.


      Authors
      Marotte, Jeffrey (Conway, AR); Marotte, Jeffrey; Alobuia, Wilson; Alobuia, Wilson; Frazier, Rochelle; Frazier, Rochelle; Stout, Richard; Stout, Richard
      __________________________________________________ __________________________________________________ _______________________





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      Very interesting! If this was made readily available and could be used for several compounds I'd be all about it!

      Sent from my SM-G930T1 using Tapatalk

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      Quote Originally Posted by turbolnd View Post
      Very interesting! If this was made readily available and could be used for several compounds I'd be all about it!

      Sent from my SM-G930T1 using Tapatalk
      It is available but it can be rather expensive just for a starter set you're looking at 250 or 300...

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      Hmm that is interesting,seems like a lot of steps for an injection but would be a nice addition. I would like to check one out.


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      Damn. Lol. Maybe when I'm retired.

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      It'd be nice to just have zero worries in the way of pip or things of the sort. Sometimes when running an Ace it can get burdensome.

      Sent from my SM-G930T1 using Tapatalk

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      It's definitely interesting but I do know for a fact that Sub-Q with hormones can leave quite a welt and burn like hell...

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      Hmmmmm. That makes sense. Like you got shot with a Test filled paintball. Lol.

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      Whatever I have done Sub-Q with testosterone it always left me a nice little welt...

      But I do know that this type of administration has been used for a very long time and was actually discovered back in the 30's...

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