Hormones are so damn complicated. Precursor pathways to DHT

[350zsidewayzz]

Beyond DHT – DHT Metabolites, Conversion Pathways, and DHT Variations | Anabolic Apex

I would love to be able to understand this but I don't think any human on earth truly knows the answer to a question like th for example -> dhea raises androstenedione-> androstenedione converts to DHT, dhea can also raise estrogen. DHT can have an anti estrogen effect. Dhea has reported sides of hair loss AND gyno. Symptoms of dht and estrogen. So what the fuck causes it to go where and why. Jesus man.

Before TRT test was 300 dht was 20 on a scale of like 21-80

After TRT dht is like 27 now test is like 1000 always.

So on TRT I didn't supplement dhea so I'm sure it tanked. But dht has risen slightly. So did the extra test compensate the loss of dhea shown by my dht results? And now will adding dhea to to my TRT raise dht to maybe 40 now or atleast higher? Maybe less estrogen conversion from dhea because my t is high and my estrogen is likely higher which leaves the body's (natural balancing system to convert the dhea to dht?) man the only way to tell is blood tests but shit. DHT is much more complicated than the whole HYPOTHALAMUS->GNrH->PITUITARY->LH FSH --> TEST ESTROGEN ETC.

LH also obviously stimulates the adrenal glands because HCG increases LH which also increases DHEA/PREGNENALONE. Etc. fuck. This is what I want my career to based around. Love this shit but damn is it complex

It's almost like fractals those patterns that never end or whatever. I feel like u could just keep digging deeper in this shit to figure out new names and what goes where and why



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[350zsidewayzz]

Although the path from adrenal precursor steroids to DHT was generally thought to require 5α-reduction of testosterone, recent data suggest that it instead involves conversion from androstenedione by SRD5A1 to 5a-androstanedione, followed by subsequent conversion to DHT. The 5a-androstanedione pathway to DHT therefore bypasses testosterone entirely (study).


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[350zsidewayzz]

New way to treat hair loss ? "New"

If dht is higher than androstenedione then dht has more carcinogenic effects. But if balanced with androstenedione (which has anti carcinogenic effects) it becomes balanced out. Maybe why some ppl with normal or high dht have hair? And those with normal or low don't have hair because of low androstenedione? If this kind of knowledge is out there why the fuck does finasteride exist.


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