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When & where is the steroid released form its ester?
Where does hydrolysis of nandrolone decanoate occur in the human body after release from an oil depot?
Kalicharan RW1, Bout MR2, Oussoren C3, Vromans H4.
Author information
Abstract
Long-term therapy of nandrolone (N) is recommended to increase mineral density and muscle strength. Using a parenteral sustained release drug formulation with nandrolone decanoate (ND), therapeutic N levels can be achieved and maintained. Until now, it is unknown if hydrolysis of ND into N occurs in tissue at the injection site or after systemic absorption. Therefore, hydrolysis studies were conducted to investigate the location and rate of ND hydrolysis after its release from the oil depot. ND hydrolysis was studied in porcine tissues, to mimic the human muscular and subcutaneous tissues. Additionally, the ND hydrolysis was studied in human whole blood, plasma and serum at a concentration range of 23.3-233.3μM. ND hydrolysis only occurred in human whole blood. The hydrolysis did not start immediately, but after a lag time. The mean lag time for all studied concentrations was 34.9±2.5min. Because of a slow penetration into tissue, hydrolysis of ND is found to be very low in surrounding tissue. Therefore the local generation of the active compound is clinically irrelevant. It is argued that after injection of the oil depot, ND molecules will be transported via the lymphatic system towards lymph nodes. From here, it will enter the central circulation and within half an hour it will hydrolyse to the active N compound.
PAIN IS WEAKNESS LEAVING THE BODY
SO DON'T BE A PUSSY
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Great read brother as always. Thank you for continuing to submit valuable information.
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I truly am greatfull for your appreciation. I try to post things I think would valuable to us a a community but I'm kinda disappointed. I feel there is only a handful of us that really cares about the real science behind our endeavors. It seems that some only want to stick to the rhetoric and lore of bro!science? But for us of those who truly want knowledge? I'll continue to post, what I believe to be valuable case studies.
Sincerely,
HB
PAIN IS WEAKNESS LEAVING THE BODY
SO DON'T BE A PUSSY
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Post Thanks / Like - 1 Thanks, 0 Likes, 0 Dislikes
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I love this stuff HB! I'll be the first to admit that some of it goes way over my head and sometimes i have to literally read it 3 times to grasp a third of it. None the less I love it and appreciate it! keep it coming homie!
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Originally Posted by
Themaskedrider
I love this stuff HB! I'll be the first to admit that some of it goes way over my head and sometimes i have to literally read it 3 times to grasp a third of it. None the less I love it and appreciate it! keep it coming homie!
Shit brother im the same way, got to read this stuff multiple time then google definitions, but none the less i want to know more. Thanks for chiming in, i will keep posting things i feel we could all learn from.
HB
PAIN IS WEAKNESS LEAVING THE BODY
SO DON'T BE A PUSSY
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