Thread: Pharmacon GW501516 ?

Anyone ever use Pharmacons GW501516?

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Here is a little background on 501516. It went to trials with GSK 10 or 12 years ago. It is a ppar delta agonist that had great upside to treat type 2 diabetes, cholesterol issues, on and on. Turned out to have serious anabolic activity as well. After GSK spent a million dollars to take it to trials, it didnt make it to the 3rd phase. They shut it down rather quickly, and nobody knew why until quite a while later when it was found out that it induced cancer in multiple different organs in mice and rats. For a company to spend big dough to get the rights to a drug that would be a real winner and money maker, only to drop it altogether, doesnt bode well for that drug. Tread very lightly with this one

Originally Posted by Dannyboy515

Here is a little background on 501516. It went to trials with GSK 10 or 12 years ago. It is a ppar delta agonist that had great upside to treat type 2 diabetes, cholesterol issues, on and on. Turned out to have serious anabolic activity as well. After GSK spent a million dollars to take it to trials, it didnt make it to the 3rd phase. They shut it down rather quickly, and nobody knew why until quite a while later when it was found out that it induced cancer in multiple different organs in mice and rats. For a company to spend big dough to get the rights to a drug that would be a real winner and money maker, only to drop it altogether, doesnt bode well for that drug. Tread very lightly with this one

Yes but those studies are/ would be compared to taking some absurd dosing.
Like taking 800-900mg at a time.

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Thats hard to say. Allometeic scaling is often used for a conversion factor. All im saying is that when a drug not only complicates a problem, but induces cancer in multiple organs, cant make it to a phase 3 trial, and is dropped mysteriously by a large pharma company after paying big dough to get the rights for trials, doesnt make me feel all warm and cozy inside. There was no explanation of causative factors for the cancers, length of administration, dosage, etc. So there is no way to extrapolate the effect on humans at any dosage or length of time. Is it so fantastic that it is worth finding out you have cancer in one or multiple organs, not from steroids or clen or t3 or dnp, but from a drug that you probably couldve done without? Then to further complicate the problem, you are getting the raw materials to make it from china? The place with horrible standards and not much stmpathy for shipping out drugs that may or may not kill you. Dont know that is a good route to travel, but just my .02

And this is not accurate as far as the conversion to human dosages. The trials were run at 3mg/kg/day, 30mg/kg/day, 100mg/kg/day in mice and rats. All 3 developed cancer. I dont have the allometric conversion formula in my head, but if i looked it up, these would not be considered crazy high dosages in humans. Definitely not 800 or 900mg/day.