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Treatment of gynaecomastia with raloxifene
Heres a good read on a study performed with raloxiphene, very promising for those of us who are gyno prone and dealing with it already.
We read with interest the Editorial on the treatment of gynaecomastia by
Khan & Blamey.1 They review the experience of several centres,
including their own, with the use of tamoxifen. We would like to comment
on our experience with another drug, raloxifene.
Selective oestrogen receptor modulators (SERMs) are a relatively new
family of drugs designed to act as oestrogens on some, but not all,
tissues.2 Tamoxifen is a first-generation SERM. Raloxifene, a second-generation SERM, has been extensively studied on postmenopausal women, and
is indicated for the treatment of postmenopausal osteoporosis.3 It is an
alternative to oestrogen replacement therapy in women with a history of
breast cancer.4, 5 Its anti-proliferative effect on mammary tissue is such
that prolonged use reduces the risk of breast cancer among osteoporotic
women.6
In a recent placebo-controlled short-term trial, the drug was
administered to 34 healthy males (mean age, 48 years) at the dose of 60
mg/day for one month; no subject developed gynaecomastia. Besides, serum
testosterone increased 20%, and serum estradiol decreased slightly.7
We decided to evaluate the effect of raloxifene in a series of patients
with gynaecomastia. Twelve patients aged 18-84 years were treated. Breast
enlargement was unilateral in 5 cases; its duration ranged from a few
weeks (7 cases) to several years (5 cases). Four patients were hypogonadal
by clinical criteria, and had low serum testosterone. In two patients
there was a possible drug effect (prasterone in one, ranitidine in the
other). The size of breast tissue ranged between 1.5 and 6.0 cm. All
patients had normal testes by palpation, and normal serum levels of
estradiol, LH, FSH, prolactin, and alpha-hCG. Liver function tests and serum
creatinine also were normal. The dose of raloxifene was 60 mg every other
day in 4 elderly patients (age 70 years or more), and 60 mg daily in the
remaining; the medication was given for 2-12 months. Hypogonadal patients
received, in addition, i.m. injections of testosterone enanthate, 100 mg
twice a month.
Raloxifene was well tolerated; only one young patient
reported a slight decrease in sexual potency. No subject complained of hot
flushes; there were no episodes of thrombophlebitis during follow-up. The
analgesic effect of treatment was fast (2-4 weeks) and sustained among 9
patients with pain and tenderness. The size of the gynaecomastia was
evaluated monthly by means of a caliper (all patients), and
ultrasonography (7 patients). All patients responded: there was an average
reduction in size of 61% (range: 34-100%); in 2 patients gynaecomastia
disappeared. Six of 8 eugonadal patients (75%) had a reduction in the size
of breast tissue of at least 50% (average, 73%). Among hypogonadal
patients (all of them followed with ultrasonography) gynaecomastia
disappeared in one, and size reduction in the remaining subjects ranged
between 46 and 67% (this is particularly noteworthy, since testosterone
replacement not infrequently causes or aggravates gynaecomastia due to
local aromatization to oestrogens by mammary tissue). Maximal effect was
observed during the first 2 months of treatment.
This open, observational study suggests that raloxifene may be a safe,
well tolerated and effective therapeutic alternative for drug-induced or
idiopathic gynaecomastia in men of all ages.
Zulema Man, MD.
TIEMPO, Buenos Aires, Argentina
Ariel S¨¢nchez, MD, PhD;
Hugo Carretto, MD;*
Ricardo Parma, MD.
Centro de Endocrinolog¨ªa,
Rosario, Argentina
References
1. Khan HN, Blamey RW. Endocrine treatment of physiological gynaecomastia.
Br Med J 2003;327:301-2.
2. Compston JE. Selective oestrogen receptor modulators: potential
therapeutic implications. Clin Endocrinol 1998;48:389-91.
3. Agnusdei D, Iori N. Raloxifene: results from the MORE study. J
Musculoskel Neuron Interact 2000;1:127-32.
4. Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA,
Norton L, Nickelsen T, Bjarnasson NH, Morrow M, Lippman ME, Black D,
Glusman JE, Costa A, Jordan VC. The effect of raloxifene on risk of breast
cancer in postmenopausal women. J Am Med Ass 1999;281:2189-97.
5. Mincey BA, Morahan TJ, Perez EA. Prevention and treatment of
osteoporosis in women with breast cancer. Mayo Clin Proc 2000;75:821-9.
6. Cauley JA, Norton L, Lippman ME, Eckert S, Krueger KA, Purdie DW,
Farrerons J, Karasik A, Mellstrom D, Ng KW, Stepan JJ, Powles TJ, Morrow
M, Costa A, Silfen SL, Walls EL, Schmitt H, Muchmore DM, Jordan VC.
Continued breast cancer risk reduction in postmenopausal women treated
with raloxifene: 4-year results from the MORE trial. Breast Cancer Res
Treatment 2001;65:125-34.
7. Uebelhart B, Bonjour JP, Draper MW, Pavo I, Basson R, Rizzoli R.
Effects of selective estrogen receptor modulator raloxifene on the
pituitary gonadal axis in healthy males (Abstract). J Bone Miner Res
2000;15(Suppl 1):S453.
Competing interests: *
None declared
"Always push towards your goals and never settle for less"
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Very nice read mean. I think someone else posted the link for this or something similar. Hopefully some more DOMESTIC sources start carrying this stuff. I would love to try but don’t want to pay 50 dollars for shipping for a 26 dollar of pills, but for those that are battling some serious Gyno issues I guess it would be worth it.
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So I have drug induced gyno and recently was seen by a plastic surge. And a oncologist. It was diagnosed 5 years ago. It came in suddenyl. No big deal at the time. Well I have noticed over the last couple of years it has gotten more pronounced on my left side. And it really is only noticeable to me.. but it hurts. So saw the surge. And he told me unless someone has serious gyno like growing boobs their is no reason to mess with it.. with having a muscular overdeveloped chest he told me I would never look normal after it was done. No matter how much fat or whatever he put back.. the reason being that if he was going to get the whole node he would have to take a lot out. Or he would have to leave a little to try and make it look normal. he said their is no reason for it cause as long as I take steroids they will always come back.. so he said professionaly not to touch it.. the only thing someone can do is take a ai to help prove the any further growth.. anyway the only time it really flares up is when I take large amounts of anadrol or dbol.. I was recently in almost 1.7grams of test and never had a issue. But yes I belive that if you don’t have it everyone that uses should have preventive maintenance drugs on hand in case of a emergency..
Everyone wanna be a Beast, Until it’s time to do what Beast’s Do!!!
I S Y M F S
(It’sStillYourMutherfuckingSet)
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Post Thanks / Like - 1 Thanks, 1 Likes, 0 Dislikes
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Originally Posted by
MrBash
So I have drug induced gyno and recently was seen by a plastic surge. And a oncologist. It was diagnosed 5 years ago. It came in suddenyl. No big deal at the time. Well I have noticed over the last couple of years it has gotten more pronounced on my left side. And it really is only noticeable to me.. but it hurts. So saw the surge. And he told me unless someone has serious gyno like growing boobs their is no reason to mess with it.. with having a muscular overdeveloped chest he told me I would never look normal after it was done. No matter how much fat or whatever he put back.. the reason being that if he was going to get the whole node he would have to take a lot out. Or he would have to leave a little to try and make it look normal. he said their is no reason for it cause as long as I take steroids they will always come back.. so he said professionaly not to touch it.. the only thing someone can do is take a ai to help prove the any further growth.. anyway the only time it really flares up is when I take large amounts of anadrol or dbol.. I was recently in almost 1.7grams of test and never had a issue. But yes I belive that if you don’t have it everyone that uses should have preventive maintenance drugs on hand in case of a emergency..
Great info for sure brother. Only issue with Gyno is that until one has it and combats it they never really know what works for them. So to have everything on hand, you could be talking about 3 different AI’s and a few SERMS. Not that it is a big deal, just saying there is always a lot of advice, great advice, given out but at the end of the day so many people are different. Like some guys take Aro 12.5 EOD, shit I got gyno sides while ON that shit! Lol. I’m using Letro now, running it with some proviron as well and I’ve been fucking like a jack rabbit still so I’m hoping it stays that way!
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