Thread: WHAT IS BAT{brown adipose tissue/brown fat}??

BAT(brown adipose tissue) thermogenic tissue that can be activated to burn fat.

New Research:
**drug for overactive bladder 50mg mirabegron (1) the drug increased brown fat metabolic activity. Resting metabolic rate also rose by an average of 203*calories per day. The increase in metabolic rate was associated with the increase in brown fat activity. 200 milligrams of mirabegron induced the fat burning. Catecholamime derivatives to stimulate BAT, -specific β3-adrenergic receptor agonists were successfully used in rodents to increase BAT activity, and ameliorate obesity and insulin resistance. In lean men, a β3-adrenergic agonist increased fat oxidation and insulin sensitivity, but it failed to alter energy expenditure after 8 weeks of use. Single-dose administration of 1000 mg of the novel beta(3)-adrenergic receptor agonist L-796568 increased lipolysis and energy expenditure in overweight men. This is the first study to show such an effect of beta(3)-adrenergic receptor agonists in humans without significant evidence for beta(2)-adrenergic receptor involvement {clenbuterol/albuterol}. Single oral dose of 1000mg of the novel beta(3)-adrenergic receptor agonist L-796568 [(R)-N-[4-[2-[[2-hydroxy-2-(3pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]-benzenesulfonamide, dihydrochloride. Mirabegron @ 200mg increased lipolysis and lowered bodyfat by 8% in obese males. The most dramatic loss was observed in the male subjects around the abdominal region.

Tips to activate BAT:
A lot of Guys are scared of cardio. They shouldnt be; when enhanced and providing the right macros and supplement/food timing, cardio is what gives that quality look by ridding you body of subcutaneous fat{white,yellow} and turn on that BAT{brown adipose tissue/brown fat that helps you burn the bad white fats, especially in the abdomen and love handle region. BAT, when activated; causes thermogenesis, burns calories and may help control blood sugar and improve insulin levels. When fully activated, just 100g of brown fat can burn 3,400 calories a day. We are all born with BAT and as we get older we lose BAT. Brown fat breaks down blood sugar (glucose) and fat molecules to create heat and help maintain body temperature. Cold temperatures activate brown fat, which leads to various metabolic changes in the body. Most of our fat, however, is white fat, which stores extra energy. Too much white fat builds up in obesity. 2 things you can do to activate BAT and burn more bodyfat are:
A) Keep thermostat at 66 degrees or below and cold showers.
B) Eat simple carbohydrates with your protein shake post workout. The carbs actually activate the BAT receptors to burn fat, not muscle.
Obviously beta 2 adrenergic agonists drugs like clenbuterol, albuterol, and bronchodilators like ephedrine hcl work well but, they do have side effects. There are also some new research compounds approved for off label use that are classified as beta 3 adrenergenic agonist drugs.

Max

Good info for all, thanks Max!

Great read. Thank you.