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Originally Posted by
IRISHOAK
Caber is a diff animal. Im prone to drinking and exploding and caber on tren helps.
I'm not explosive nor assholeish anymore. Getting booze and ciggs out of my system turned me into a way different/better person. I don't crave that garbage anymore either, when I gave that shit up I was SOOOO ready and disgusted. Unfortunately I have not been able to kick my Lays Stax addiction, but it's rather mild now lol 
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Caber binds to dopamine receptors in the brain preventing them from producing prolactin. Prolactin causes anxiety and depression.
From NCBI: Prolactin alters neural circuits to help the individual to cope with stress. Reduced activation of neural inputs, activation of ionic channels, or the modulation of several signaling pathways are some of the putative mechanisms of action underlying the effects of PRL on brain circuits. It is unknown how PRL regulates the HPA axis function during the stress response. PRL could affect hypothalamic and/or hippocampal activity to regulate emotionality.
So much like the use of estrogen AI's, caber is preventing prolactin from being produces much like aromasin would stop estrogen's from being produced.
We all know we can be moody with just testosterone due to higher levels of estrogen but far too few think of controlling prolactin while using tren. There is a correlation between prolactin and E2 which is another conversation. Too much prolactin lead's to hyperprolactinemia, I'll let you research this but as you will seem the sides are not too good. There are no researched side effects of maintaining low levels of prolactin. The worst you might see is that it might reduce some immune system responses but I would assume that would be incredibly low levels for prolonged periods of time. Much like some preach that you need some estrogen (you do) you also need some prolactin but I hate to be repetitive, but you need to control estrogen and you need to control prolactin.
BPP
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Originally Posted by
Plate Smacker
Not getting sleep is a serious driving force and seems to exasperate mental issues. Your cranky.
I just take 100mg diphenhydramine sleepaid. I found the cheap non coated, ones work faster. Gel caps are slow as hell too. That helps me get to sleep.
If I wake up middle of the night, and feel sleepless, I will just take another 50mg. Takes like 15 minutes to kick in.
Night sweats comes with the territory. I go from feeling colder and needing to cover up, then hot and needing to have the fan directly at me.
I set house temp to 65.
I found that legs exposed below the knee, with fan pointed there, keeps me just the right temp.
My wife also got me a sheet that she says regulates body temperature or some thing.
Now, the mental issue I run into is, I get pissed off at TIME.
I start to feel like I need more time and there isn't enough time to get shit done. Then I get a helpless angry feeling.
Then I stare at one spot just in a rage, and tell myself it's the Tren. Then do something fun to take the mind off of it.
Masturbation works wonders too. Post Nutt Clarity is what I call it.
I used to run Deca pretty high while running Tren.
Like 900 Test E, 900 Deca, 75mg Tren A(or 600mg Tren E)
Now, since I lowered my Deca when using Tren, alot of the mental stuff has went away pretty much.
Right now finishing 900 Test E, 600 Tren E, 200mg Deca.
No AI, No DA, Nolva to block @ 20mg E3D
Cialis @ 10mg ED
Been pretty great, but the night sweats will happen here and there regardless.
Another note is there are studies on low estrogen and relationship Jealousy. I was taking cookie cutter dose of Aromasin, and with estrogen in Range, thought I was fine.
NOPE. Way to low if taking supra physiological dosages of gear. Letting my estrogen stay higher, got rid of the insane mental issues I was having when I was first running Tren A.
If your running AI and having mental issues, try lowering or removing AI, block with Nolva, and have a DA handy just in case, since you are letting your estrogen run higher.
I agree with the low E2 while on Tren and Mast. I learned the hard way no AI with those stacked. MUCH less undesirable sides. Some guys complain because Estrogen is now added to Tren but I love it. My friends that ran Finaplex we're always angry asf but leans asf tho.
Damn good to see you've picked up on this. My logs prove this to be true IME as well.
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Originally Posted by
bigpapapumpaf
I have preached about this for years. If you take caber and all other things are in order, you will not have any emotional side effects from tren.
Its all dopamine related.
ALSO prami is not the same as caber, do not be misled.
BPP
Fuck Prami. Projectile vomiting sucked a donkey dick....or is it the other way around....suck a donkey dick "then" projectile vomit. Yahhhhh I know not funny. Nahh real talk it made me throw up...violently.
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“Live for something...or Die for nothing “
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Originally Posted by
ilovehgh
I'd like to try caber, but taking stuff that directly affects brain chemistry is a no go for me.
What THE FUCK do you think Tren does to your brain!?! I'm just fucking with you, on THE FUCK part, but real talk Tren has profound affects on brain chemistry. Taking Caber is an attempt to balance what Tren throws outta whack. Deca/NPP affect the brain as well.
Here read the below and start there. You can use the info in the medical journals to gain some direction in further doing your own research.
17β-trenbolone, an anabolic–androgenic steroid as well as an environmental hormone, contributes to neurodegeneration (Journal Article) | OSTI.GOV
17β-trenbolone's distribution and its effects on serum hormone levels and Aβ42 accumulation in vivo and its effects on AD related parameters in vitro were assessed. 17β-trenbolone accumulated in adult rat brain, especially in the hippocampus, and in the fetus brain. It altered Aβ42 accumulation. 17β-trenbolone induced apoptosis of primary hippocampal neurons in vitro and resisted neuroprotective function of testosterone. Presenilin-1 protein expression was down-regulated while β-amyloid peptide 42 (Aβ42) production and caspase-3 activities were increased. Both androgen and estrogen receptors mediated the processes. 17β-trenbolone played critical roles in neurodegeneration. Exercisers who inject large doses of trenbolone and common people who are exposed to 17β-trenbolone by various ways are all influenced chronically and continually.
Highlights: The widely used anabolic–androgenic steroid 17β-trenbolone has neurotoxicity. 17β-trenbolone crosses the blood brain barrier and placental barrier. Rat has high level of 17β-trenbolone in hippocampus after intramuscular injection. 17β-trenbolone induces apoptosis of primary hippocampal neurons. 17β-trenbolone affects Alzheimer's disease-related proteins Aβ42.
This is an article that addresses AAS use in general....
How do anabolic steroids work in the brain? | National Institute on Drug Abuse (NIDA)
Research with human cells demonstrates that anabolic steroids also interact with certain types of GABAA receptors, which could mediate the increased anxiety reported by steroid users.105,106 In addition, animal studies show that anabolic steroids increase serotonin levels in brain regions involved in mood107 and dopamine levels in reward-related brain regions.107,108 Chronic use of anabolic steroids has also been shown to cause dysfunction of these reward pathways in animals. Specifically, rats given twice daily nandrolone injections for four weeks showed loss of sweet preference (a sign of reward dysfunction) that was accompanied by reductions of dopamine, serotonin, and noradrenaline in the nucleus accumbens, a reward-related brain region.
This is a "go to" site of mine...
Brain and Cognition Abnormalities in Long-Term Anabolic-Androgenic Steroid Users
Long-term AAS use is associated with right amygdala enlargement and reduced right amygdala rsFC with brain areas involved in cognitive control and spatial memory, which could contribute to the psychiatric effects and cognitive dysfunction associated with AAS use.
Last edited by Riggs; 01-11-2021 at 05:43 AM.
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Originally Posted by
Riggs
What THE FUCK do you think Tren does to your brain!?! I'm just fucking with you, on THE FUCK part, but real talk Tren has profound affects on brain chemistry. Taking Caber is an attempt to balance what Tren throws outta whack. Deca/NPP affect the brain as well.
Here read the below and start there. You can use the info in the medical journals to gain some direction in further doing your own research.
17β-trenbolone, an anabolic–androgenic steroid as well as an environmental hormone, contributes to neurodegeneration (Journal Article) | OSTI.GOV
17β-trenbolone's distribution and its effects on serum hormone levels and Aβ42 accumulation in vivo and its effects on AD related parameters in vitro were assessed. 17β-trenbolone accumulated in adult rat brain, especially in the hippocampus, and in the fetus brain. It altered Aβ42 accumulation. 17β-trenbolone induced apoptosis of primary hippocampal neurons in vitro and resisted neuroprotective function of testosterone. Presenilin-1 protein expression was down-regulated while β-amyloid peptide 42 (Aβ42) production and caspase-3 activities were increased. Both androgen and estrogen receptors mediated the processes. 17β-trenbolone played critical roles in neurodegeneration. Exercisers who inject large doses of trenbolone and common people who are exposed to 17β-trenbolone by various ways are all influenced chronically and continually.
Highlights: The widely used anabolic–androgenic steroid 17β-trenbolone has neurotoxicity. 17β-trenbolone crosses the blood brain barrier and placental barrier. Rat has high level of 17β-trenbolone in hippocampus after intramuscular injection. 17β-trenbolone induces apoptosis of primary hippocampal neurons. 17β-trenbolone affects Alzheimer's disease-related proteins Aβ42.
This is an article that addresses AAS use in general....
How do anabolic steroids work in the brain? | National Institute on Drug Abuse (NIDA)
Research with human cells demonstrates that anabolic steroids also interact with certain types of GABAA receptors, which could mediate the increased anxiety reported by steroid users.105,106 In addition, animal studies show that anabolic steroids increase serotonin levels in brain regions involved in mood107 and dopamine levels in reward-related brain regions.107,108 Chronic use of anabolic steroids has also been shown to cause dysfunction of these reward pathways in animals. Specifically, rats given twice daily nandrolone injections for four weeks showed loss of sweet preference (a sign of reward dysfunction) that was accompanied by reductions of dopamine, serotonin, and noradrenaline in the nucleus accumbens, a reward-related brain region.
This is a "go to" site of mine...
Brain and Cognition Abnormalities in Long-Term Anabolic-Androgenic Steroid Users
Long-term AAS use is associated with right amygdala enlargement and reduced right amygdala rsFC with brain areas involved in cognitive control and spatial memory, which could contribute to the psychiatric effects and cognitive dysfunction associated with AAS use.
Sounds like if you suffer from severe depression,generalized anxiety disorders all this stuff will affect all tjay in a bad way,I notice I’m more prone to depressive feelings while I’m on nandrolone ,I started a cycle 2 week ago and already I’m more depressed when something happens negative to me
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“Live for something...or Die for nothing “
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I love tren my self I must be crazy I guess. Its my favor after test
I do stay on p5p protocol year around
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