Thread: 🔥🔥 LIST OF MEDICAL LITERATURE DATABASES

Originally Posted by Riggs

Figured I'd post, some stuff I find very interesting, here in this thread.

I've copy/pasted the abstract and provided the link because the full text is much more informative.

Effects of Progesterone and Estradiol Sex Hormones on the Release of Microparticles by RAW 264.7 Macrophages Stimulated by Poly(I:C) | Clinical and Vaccine Immunology

Effects of Progesterone and Estradiol Sex Hormones on the Release of Microparticles by RAW 264.7 Macrophages Stimulated by Poly(I:C)

David S. Pisetsky, Di

ABSTRACT

Microparticles (MPs) are small membrane-bound vesicles that display proinflammatory and prothrombotic properties. These particles can be released by macrophages stimulated by ligands of the Toll-like receptors (TLRs) in a process that depends on nitric oxide (NO) production. Since sex hormones can modulate macrophage responses, we investigated the effects of progesterone and estradiol on macrophage particle release in vitro, comparing the responses with those induced by the glucocorticoid dexamethasone. As a model system for particle release, RAW 264.7 cells were stimulated in vitro with poly(I:C), a ligand of TLR3. Microparticles were measured by flow cytometry, while NO was measured by the Griess reaction. As the results of these studies showed, progesterone but not estradiol can block particle release by RAW264.7 cells treated with poly(I:C); dexamethasone was also active. Furthermore, while progesterone and dexamethasone inhibited NO production under the same culture conditions, neither agent blocked the production of particles stimulated by the NO donors dipropylenetriamine NONOate {(z)-1-[N-(3-aminopropyl)-N-(3-ammoniopropyl)amino] diazen-1-ium-1,2-diolate} and (z)-1-[(2-aminoethyl)-N-(2-ammonioethyl)amino] diazen-1-ium-1,2-diolate. Studies using RU486 to assess the role of hormone receptors indicated that while this agent blocked the inhibition of particle and NO production by dexamethasone, it did not affect the inhibition by progesterone. Together, these results indicate that progesterone but not estradiol can inhibit particle release by stimulated macrophages and suggest a mechanism that may contribute to the immunomodulatory effects of this sex hormone.

Article
Studies using RU486 to assess the role of hormone receptors indicated that while this agent blocked the inhibition of particle and NO production by dexamethasone, it did not affect the inhibition by progesterone.

Such a trip, the morning after pill !! RU486.
The most powerful steroid in the world is RU2420, dimethyltrienolone. {not mtren, cheque drops, or trenavar, Just an FYI. I lost my head for like a week when I got the access to the catalogued list of every steriod/hormone/prohormone/designer steroid/ped ever made and a full description of what they knew about it. It literally would take years to go through ,
And Some are made and nobody even knows much about it. It will take me years to go through it along with everything else. Fun

Max

Originally Posted by maxmuscle1

Article
Studies using RU486 to assess the role of hormone receptors indicated that while this agent blocked the inhibition of particle and NO production by dexamethasone, it did not affect the inhibition by progesterone.

Such a trip, the morning after pill !! RU486.
The most powerful steroid in the world is RU2420, dimethyltrienolone. {not mtren, cheque drops, or trenavar, Just an FYI. I lost my head for like a week when I got the access to the catalogued list of every steriod/hormone/prohormone/designer steroid/ped ever made and a full description of what they knew about it. It literally would take years to go through ,
And Some are made and nobody even knows much about it. It will take me years to go through it along with everything else. Fun

Max

If you have it give me the link. Shot ya a pm with my email. Don't give it out jackass it's mostly for Sponsors.....but hey "because it's you."

Originally Posted by Riggs

If you have it give me the link. Shot ya a pm with my email. Don't give it out jackass it's mostly for Sponsors.....but hey "because it's you."

Done

Max

Originally Posted by maxmuscle1

The most powerful steroid in the world is RU2420, dimethyltrienolone. {not mtren, cheque drops, or trenavar, Just an FYI.

Max

Yahhh I'd say so....Anabolic/Androgenic Ratio: >10,000/>10,000

Originally Posted by Riggs

Yahhh I'd say so....Anabolic/Androgenic Ratio: >10,000/>10,000

Sick! It is 100x the A:A ratio of methyl testosterone which is crazy strong and harsh. I actually had 360 prescribed of Testred.and I could feel like effects quickly 10mg 3x daily. I went on a school trip and when I got home, my mom was cleaning and threw them out!! She just read the first part before the testosterone part of the prescription bottle and thought it was something else; I wanted to strangle her. Anyway; they were hard on me and I went back to Cypionate. I wonder if someone ever put a tiny bit of it in a formula. Shit would melt your liver or shut you down. Make you go nuts too! Like Tren 10,000!! Lol

Max