-
My YK-11 Experiment
Details to be posted soon. I have a theory.
Am I right? Time will tell!
20220703_174129_HDR.jpg
"Going that one more round, when you don't think you can, is what makes all the difference in your life."
-
Post Thanks / Like - 3 Thanks, 4 Likes, 0 Dislikes
----
-
Ok before we begin I gotta hit you guys with some reading assignments, so we are all on the same page...
Key Point #1:
YK-11 does NOT inhibit myostatin, it elevates Follistatin levels.
(The following abstract from PubMed explains the relationship between the two.)
Abstract
Follistatin is known to antagonise the function of several members of the TGF-beta family of secreted signalling factors, including Myostatin, the most powerful inhibitor of muscle growth characterised to date. In this study, we compare the expression of Myostatin and Follistatin during chick development and show that they are expressed in the vicinity or in overlapping domains to suggest possible interaction during muscle development. We performed yeast and mammalian two-hybrid studies and show that Myostatin and Follistatin interact directly. We further show that single modules of the Follistatin protein cannot associate with Myostatin suggesting that the entire protein is required for the interaction. We analysed the interaction kinetics of the two proteins and found that Follistatin binds Myostatin with a high affinity of 5.84 x 10(-10) M. We next tested whether Follistatin suppresses Myostatin activity during muscle development. We confirmed our previous observation that treatment of chick limb buds with Myostatin results in a severe decrease in the expression of two key myogenic regulatory genes Pax-3 and MyoD. However, in the presence of Follistatin, the Myostatin-mediated inhibition of Pax-3 and MyoD expression is blocked. We additionally show that Myostatin inhibits terminal differentiation of muscle cells in high-density cell cultures of limb mesenchyme (micromass) and that Follistatin rescues muscle differentiation in a concentration-dependent manner. In summary, our data suggest that Follistatin antagonises Myostatin by direct protein interaction, which prevents Myostatin from executing its inhibitory effect on muscle development.
Source: Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis - PubMed (nih.gov)
Last edited by IRISHOAK; 07-05-2022 at 09:45 PM.
"Going that one more round, when you don't think you can, is what makes all the difference in your life."
-
Post Thanks / Like - 2 Thanks, 2 Likes, 0 Dislikes
----
-
So it's going to be tested out. Nice!! I definitely wanna know more about it. I will keep an eye on this thread. Please update us on this. Thanks Oak. 
-
Post Thanks / Like - 1 Thanks, 1 Likes, 0 Dislikes
----
-
Originally Posted by
Mr.Beefy
So it's going to be tested out. Nice!! I definitely wanna know more about it. I will keep an eye on this thread. Please update us on this. Thanks Oak.
Definitely will. Im gonna lay out all the science, then my theory, then run my protocol and log it. You will get all the info
"Going that one more round, when you don't think you can, is what makes all the difference in your life."
-
Post Thanks / Like - 3 Thanks, 4 Likes, 0 Dislikes
----
-
Originally Posted by
IRISHOAK
Definitely will. Im gonna lay out all the science, then my theory, then run my protocol and log it. You will get all the info
Awesome! I'm so stoked for this.
-
Post Thanks / Like - 1 Thanks, 1 Likes, 0 Dislikes
----
-
Originally Posted by
IRISHOAK
Definitely will. Im gonna lay out all the science, then my theory, then run my protocol and log it. You will get all the info
Will definitely check it out as it has been one time I’ve tried a few times for 2-4 weeks orally by itself. It is not weak ! Cannot wait to see you plan (or even future experiment) 
Max
-
Post Thanks / Like - 1 Thanks, 1 Likes, 0 Dislikes
----
-
Starting the YK-11 tonight. I stopped everything except test so we can give a proper run.
20220712_171507_20220712172009959.jpg
"Going that one more round, when you don't think you can, is what makes all the difference in your life."
-
Post Thanks / Like - 2 Thanks, 3 Likes, 0 Dislikes
----
-
Ok, so for reasons Ill go into when I have a little more time to post... I think YK11 can be a powerful tool, I also think that based on all the anecdotal evidence & what little science there is on it, that people have been making 2 mistakes:
1. Dosing too high
2. Dosing too often
Took my first dose of 5mg. (This is just to start small and make sure I dont have some weird reaction or anything, "Always "taste" it before you actually TRY it, write that down!" Lol! It applies to everything!)
More updates & details soon...
20220713_202348_HDR.jpg
"Going that one more round, when you don't think you can, is what makes all the difference in your life."
-
Post Thanks / Like - 2 Thanks, 2 Likes, 0 Dislikes
----
-
Nice ! Look forward to a more in depth read about your experience once your a few weeks in. It’s no joke - YK11
Max
-
Post Thanks / Like - 2 Thanks, 2 Likes, 0 Dislikes
----
-
I'll tell you this much, I took 5mg yesterday and I FELT growth this morning. You guys know that feeling when you are in the sweet spot of a cycle and really gaining? You wake up and stand up out of bed and you kinda feel pumped & heavier in places, esp in the places you just hit in the gym? Had that feeling all up in my lats, rear delts & arms today upon waking!
"Going that one more round, when you don't think you can, is what makes all the difference in your life."
-
Post Thanks / Like - 2 Thanks, 2 Likes, 0 Dislikes
----
maxmuscleone thanked for this post
maxmuscleone liked this post
Reply With Quote
Bookmarks