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    Thread: Arimidex

    1. #1
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      Arimidex (anastrozole)

      Arimidex

      (anastrozole)

      Arimidex (anastrozole) is what we call an aromatase inhibitor (AI). In clinical use, it´s used to halt the progression of Breast Cancer in women. It works by blocking the aromatase enzyme, which is responsible for the production of estrogen. In athletics and bodybuilding, it is used as an ancillary compound to be added to a cycle of AAS. In this respect it is also used for its estrogen reducing properties, but it has the additional benefit of increasing testosterone levels, as we´ll see...

      Arimidex Side Effects

      Many AAS aromatize (convert to estrogen via the aromatase enzyme), and this is responsible for many of the unwanted side effects found with anabolic steroid use (acne, gynocomastia, water-retention, etc...). In one study, both .5mg and 1mg doses of Arimidex were shown to decrease estrogen by roughly 50%. The 1mg/day dose also increased testosterone levels by 58% (1). In that same study, in both groups, LH and FSH also went up slightly.

      Take a look:

      Changes in testosterone and E2 concentrations in normal young men (15- 22 yr old) before () and after 10 days of oral anastrozole at 0.5 and 1 mg.(1)

      This would seem to suggest that for use during a cycle, a dose of .5mgs/day would be sufficient to combat estrogen-related side effects. It is, however, important to remember that some estrogen is necessary to obtain optimal muscle growth. The lower estrogen levels provided by ´dex seems, anecdotally at least, to produce a more "hard" and "quality" look for bodybuilders who have experimented with it´s use in either a cutting or bulking cycle.


      I´d like to point out that the elevation in Testosterone provided by Arimidex is so large that it can be used as a "form" of testosterone replacement therapy for hypogonadal men (2). Clearly, this suggests its use in a post-cycle-therapy (as well as its previously discussed use within a cycle) to regain natural testosterone levels and full functioning of the HPTA (Hypothalamic-Testicular-Pituitary-Axis).


      Literature provided by the original maker of anastrozole (Arimidex, produced by Zeneca Pharmaceuticals) states that stable blood plasma concentrations of the compound are achieved after a mere 7 consecutive 1mg daily doses. Also, Arimidex is just over 80% effective at inhibiting aromatase (3). Thus, if you want to take it for the entire duration of a cycle of AAS.


      But can you use it for the entire duration of a cycle? Is it dangerous? Well, certainly reducing estrogen levels in your body is good from a body building point of view, as it reduces water-retention and the potential for gynocomastia (if there´s no estrogen in your body, you can´t get gyno, regardless of how much progesterone is floating around)(5). Luckily this stuff is very mild on blood lipids (cholesterol) and doesn´t affect them adversely (2), in the studies I´ve seen.
      Arimidex and Cholesterol

      As previously mentioned, those lowered estrogen levels could possibly (eventually) adversely affect your cholesterol and possibly even your immune function. I am, however, very comfortable recommending Arimidex for relatively long-term use. This should be the ancillary compound of choice for those on long and heavy cycles, especially since it also doesn´t inhibit IGF like some other ancillary compounds (Insulin-like-growth-factor is an important component of anabolism)(4).

      Price of Arimidex

      Though price of Arimidex will vary, this is one of the compounds I will caution the reader from buying in its legitimate pharmaceutical form. The price (up to $5/tab) is absurd, when you consider its availability from Underground Labs, as well as in research form, for less than 1/3rd of that. I´ve used both the tabs from an Underground Lab, as well as the liquid version from research-sites, and found the results from both to be exactly the same.
      Last edited by STEROID; 11-24-2011 at 11:22 PM.

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      Very informative, by 'liquid' you mean injectable or oral?

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      Meening
      Oral liquid research type and (UG) under ground pill vs Pharmasutical press tabs = same effects
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      I just happened to be very lucky. a woman friend of mine had some type of cancer so she arimidex but it made her sick and they changed he rx so she would just give them to me 300 tabs and they would bill her insurance $170 for 30 tabs and all I would get them from her for $10 cant beat that ,I had another friend that got 1 bottle of watson test depot or sandoz test depot both were 200mgs of cyp, but to be totaly honest with ya I had a good ug connect that I could not even tell the differance , I actully liked the andropen275 better probally because it had the fast acting esters in it and nit just the long acting esters, so I have come to relize that if its legit test is test
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      sounds like this would be a great addition to any cycle.

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      This is the best summary I've found that explains how it works efficiently. Thanks a bunch.

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      Great info, very clear!

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      There is also the opinion that arimidex is powerful enough that it will crash your e2 levels if you take too large of a dose too often. Just a sliver every couple days is better than just popping 1 mg at a time and crashing your E2. It can take months to recover from crashed estrogen.

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      So for an eq-test cycle of 500ml per week, a sliver every few days, but how long do you continue after your final injection?

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      Quote Originally Posted by Ronnoco View Post
      So for an eq-test cycle of 500ml per week, a sliver every few days, but how long do you continue after your final injection?
      Hmmm. I personally wouldn’t do that. Sliver!? What does that mean in mgs?

      Have you run 500mg a wk? Did you run bloods to see where e2 was at so you know how much AI, if any you need?

      This is how and why so many will say that on 500mg a wk they don’t need any AI. Others will say 12.5mg asin a wk and others will say 2x a wk.

      I hate adex as no matter what, why, when or how I feel like shit, I am tired and cannot regular my e2.

      My guess, that’s all it is, on 500mg, you would need adex .25-.5 2x a wk BUT...

      I would rec asin at 12.5mg. On 500 I take 12.5 mg every 4 days.




      I am a part time Proctologist and full time Gynecologist Arimidex

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