• Amused
  • Angry
  • Annoyed
  • ArrgPirate
  • atwork
  • Awesome
  • Bemused
  • Cocky
  • Cool
  • Crazy
  • Crying
  • deejayn
  • Depressed
  • Down
  • drinking
  • Drunk
  • eating
  • editing
  • Embarrased
  • Enraged
  • Friendly
  • gamingpc
  • gamingps
  • gamingsteam
  • gamingxbox
  • Geeky
  • Godly
  • Happy
  • hatemailing
  • Hungry
  • Innocent
  • lagging
  • livestreaming
  • loving
  • lurking
  • Meh
  • netflix
  • nostatus
  • Poorly
  • raging
  • Sad
  • Secret
  • Shy
  • Sneaky
  • Tired
  • trolling
  • Wtf
  • youtuber
  • zombies
  • Page 1 of 2 12 LastLast
    Results 1 to 10 of 13

    Thread: DHT Explained.

    1. #1
      Senior Member
      is CRUIZIN
       
      I am:
      Tired
       
      Hatebreed's Avatar
      Join Date
      Aug 2017
      Location
      West coast
      Posts
      1,151
      Post Thanks / Like
      Rep Power
      4675

      DHT Explained.

      I've been researching DHT steroids (Avavar, Winstrol, Anadrol, Primbolan, Masteron) and can't seem to find many differences in them.
      Could someone explain why you would pick one over another? Also which is your favorite and why?






      They all do different things. Masteron, primo, Anavar and winstrol are for the most part body building drugs that will pack in quality, lean mass. They're more androgenic than anabolic. Masteron can be used for it's estrogen control and help with libido as well as being a great "finisher" really hardening up and bringing the package together before a show. Winstrol is similar in that it will "dry" a person out.
      Anadrol will put on mass and it will so rapidly. Most is water weight. If at a lean enough BF it can really help fill out a physique. It's sometimes used by bodybuilders before a show.
      Anavar and anadrol are used by powerlifters for the great strengh gains.
      I remember reading somewhere that all DHT based steroids increases the efficiently of the CNS.
      I hope this helps a bit. Someone should come along with more input.
      And I found this:
      DHT stands for dihydrotestosterone. It is a very close chemical cousin of testosterone and has many important functions in the body. It is responsible for the sexual differentiation that occurs in the womb way before we are even born. It is the dihydrotestosterone levels in the womb that determine whether or not the fetus will develop into a male or female. So, you can imagine, this is a pretty strong androgen. DHT is the most androgenic of hormones. Its responsibility lies in all of the male secondary sexual characteristics such as deepening of the vocal chords, male hair patterns on the body, hair on the face, oily skin (especially when you first hit puberty and your natural test is raging), and last but definitely not least, male sexual drive and function.
      A few years ago, scientists also determined that it is DHT that plays a pivotal role in hair loss. If you have the gene for it, male pattern baldness becomes evident as these molecules attach at the scalp, over-stimulate the hair follicles, and cause the root to die and the hair follicle to fall out. The hair root becomes unhealthy and unable to support the follicle. Rogaine, the popular topical agent for combating hair loss works by seeping into the hair follicles and decreasing the hormonal affects on the root. Rogaine’s protective effects only last for a few hours which is one of the reasons you must put it in your scalp multiple times per day (pain in the ass, but not as bad as a Sustanon knot in the glute!).
      Okay, anyway, why is this hormone important and how does it function into our goal of massive and ripped physiques? DHT is an extremely potent non-aromatizing androgen. It will not aromatize at any dosage whatsoever. Drugs that are derivatives of this hormone (cousins) also tend to be non-aromatizing (there are exceptions which we’ll get in to). It is important to understand that a drug may be a specific derivative, and still have other estrogenic and/or progestagenic affects, however. Not to confuse for now. This will be explained in the pages on estrogenic and progestagenic affects of anabolic steroids. For now, and for simplicity sake, lets say that DHT means hardening of the physique, lack of water retention, favorable fat-loss, increased sex drive, and increased strength gain. Let’s talk about each of these points.
      Hardening of the physique and lack of water retention go hand in hand. It does not aromatize while being the gold standard of “androgenic” drugs. This causes a direct hardening affect on the muscle tissue. The lack of aromatization and the fact that the drug is prototypical androgen, causes a significant shift in the body’s estrogen/testosterone ratio. The effects of estrogen on the physique are pretty much out-shadowed by the heavy androgenic component of the non-aromatizing DHT. The heavy androgenic affect stimulates the pituitary in a manner which directly stimulates the adreno-pituitary portals to stimulate neurological excitation of brain areas that are sexually oriented. The sex drive goes up. Let’s see, so far we have a harder and more ripped physique, higher sex drive, no water retention, and significant strength gain stimulation. What the heck is bad here? Well this is where the physiological behavior of anabolic steroids becomes a little more complicated. Up unto this point, I have described the DHT that is in the male body. Anabolic steroids that share a close chemical structure to DHT do not exclusively share this property. What this means is that an anabolic steroid may be a DHT derivative and yet have estrogenic affects. An anabolic steroid may also be a derivative and have a progestagenic affect. If this sounds confusing, hang in there, it will be clear in a few paragraphs. This stuff is not nearly as complicated to understand as it may seem. To fully understand these events, however, we will have to delve into the physiological response of hormonal receptors.
      In basic physiology 101, you learn that hormones are like keys, and receptors for the hormones are like locks. The key must fit into the lock, turn it, and ultimately unlock the mechanism inside. Make sure to follow this next example, it will prove very useful when we talk about hormonal receptor blockers for various drugs… 1. Key fits into lock (hormone molecule floats its way through the blood and finds its intended receptor). 2. Key is able to turn the lock (the hormone fits nicely into the receptor but has not yet activated it). 3. The key is able to turn the lock and succeeds in locking or unlocking the mechanism (the physiological outcome occurs; the main function of that given hormone is now able to exert its effect). Now imagine a master key that can fit all locks. Some drugs are very similar to master keys. At least, with respect to the functions we are interested in. Most anabolic steroids, are like multi-function keys…there are a few different types of locks that they can fit into, turn, and unlock. In our terms hormones that can fit into different types of receptors. This is extremely important depending on what drug we are talking about, and what receptors it is able to fit into and activate.
      Examples of DHT Action
      Lets’ illustrate this with some examples. The popular and powerful weight gain favorite, anadrol. Our good old A-bombs or drol can is a dual function key. It can fit into and activate the androgen receptor (the lock and key function we want), or it can weakly fit into the progesterone receptor. Now, I understand that many may disagree, however it is a biochemical fact that due to chemical structure, androl (oxymetholone) cannot convert into estrogen. I’m sure you know someone who has gotten sore tits or gynocomastia from drol. How can this happen if drol is non-aromatizing? Well, the male body unfortunately has receptors for progesterone in the breast. What? Yup. Not many, but enough that if we had more progesterone in our systems, they may become activated. What is one of the functions of progesterone in the female? Stimulation of breast tissue growth. Yikes!! Going back to drol, this is what happens. The body recognizes the androgen. However, to the body, it looks a little bit like progesterone too. When the drug circulates enough times throughout the body with repetitive dosages, some drol molecules find progesterone receptors. The drol has chemical similarities to progesterone in its actual chemical structure. All you need is a few progesterone receptors to pick up a few molecules of drol and wham!!!---Bitch Titty Central.
      We all know that estrogen stimulates breast tissue as well. You know what not to do if you are prone to water retention due to the estrogenic affects of some anabolics? You know, your body is the type that holds a little more fat, you lose some vascularity when you do things such as test and d-bol, etc. Don’t combine aromatizing drugs with drol!! Think about it. Oh wait. Yeah, the male breast has receptors for estrogen as well. You probably knew that but hang on. Okay…now you have drol exerting a progestagenic affect at the male progesterone receptors in the breast, and, elevated estrogen from whatever other aromatizing anabolic you are using affecting estrogen receptors in the male breast. Now, personally, I’ve always been a breast guy but…are you getting the picture. You are combining two of the most significant and potent hormonal affects together, in the male body, that are responsible for breast tissue growth stimulation in the female. Don’t do it!!
      Okay, this section is supposed to be about DHT derived drugs. I needed to tell you guys the above info for obvious reasons. Sorry for my tangent, blame the few good buddies I’ve had that have combined huge amounts of test with drol and grown some unsightly problems. Two grand a piece usually to have those bad boys removed. Okay, anyways, back to DHT derived drugs…





      PAIN IS WEAKNESS LEAVING THE BODY
      SO DON'T BE A PUSSY


    2.    Sponsored Links

      ----
    3. #2
      Banned
      This user has no status.
       
      I am:
      nostatus
       

      Join Date
      Mar 2016
      Posts
      5,207
      Post Thanks / Like
      Rep Power
      100343
      Interesting information! Thanks for posting. Might save someone from getting a nice rack lol


      Sent from my iPhone using Tapatalk Pro

    4. Thanks Hatebreed, babybull34 thanked for this post
      Likes Hatebreed, babybull34 liked this post
    5. ----
    6. #3
      BOP VETERAN
      is Low test lots of primo
       
      I am:
      atwork
       

      Join Date
      Aug 2015
      Posts
      4,777
      Post Thanks / Like
      Rep Power
      56679
      I love DHT drugs imo they are the best....how are they different well I guess u could look at it like this some steroids are testosterone derivatives.....however work very different then just test.... All DHT drugs chemically would be different there for will act differently in your body.....

    7. Thanks babybull34 thanked for this post
      Likes babybull34, HustleHard liked this post
    8. ----
    9. #4
      Senior Member
      is Pursuing Happiness
       
      I am:
      Hungry
       
      babybull34's Avatar
      Join Date
      Dec 2016
      Location
      Land of the Free
      Posts
      1,426
      Post Thanks / Like
      Rep Power
      7655
      Great post, HB. And Ski, I agree with you. The DHT-based compounds have always given the look I seek.

      One point of contention with the info posted though. Primo is a DHB, like EQ and 1-Test Cyp, not a DHT compound like Winstrol, Anavar, and Anadrol.

    10. Thanks Primemuscle, Zeus-Sr thanked for this post
      Likes Primemuscle, Zeus-Sr liked this post
    11. ----
    12. #5
      BOP VETERAN
      is Is coming back with vengence
       
      I am:
      raging
       
      Bombarinos's Avatar
      Join Date
      Jun 2017
      Location
      Santa prisca
      Posts
      4,548
      Post Thanks / Like
      Rep Power
      214231
      What about proviron in this mix fellas

    13. ----
    14. #6
      BOP VETERAN
      is Is coming back with vengence
       
      I am:
      raging
       
      Bombarinos's Avatar
      Join Date
      Jun 2017
      Location
      Santa prisca
      Posts
      4,548
      Post Thanks / Like
      Rep Power
      214231
      Masteron vs Proviron
      Mesterolone (oral 1-methyl-dihydrotestosterone) and Masteron (an injectable form of 2-methyl-dihydrotestosterne) are indeed structurally very similar. Both are DHT hormones with a minor modification (methylation) on each. This similarity, however, doesn’t carry over extremely closely when it comes to function. Both steroids are DHT derivatives, yes, and because of this there is no estrogen conversion possible with either drug. They lack a structural trait necessary for their conversion to estrogen. This characteristic may also allow both steroids to offer some level of anti-estrogenic activity, as the non-aromatizable steroid may compete with other aromatizable steroids (like your own endogenous testosterone) for binding to the aromatase enzyme. This should lower estrogen levels and heighten the ratio of relative androgenic to estrogenic activity in the body. As such, both steroids could be used to some extent for cutting or contest preparations. The main value in this regard is that both may help, instead of hinder, the visible retention of fat and subcutaneous water. With less water retained, muscle definition can increase provided body fat is low enough. But this is about where the functional similarities between the two agents end.
      The main difference between Mesterolone and Masteron is their relative level of anabolic activity in skeletal muscle. Both steroids are capable of attaching to and activating the androgen receptor in muscle tissue. As such, both are theoretically capable of supporting muscle growth. But there is one major problem with Mesterolone. Like the base steroid dihydrotestosterone, Mesterolone has a high affinity for the 3-alpha hydroxysteroid dehydrogenase (3HSD) enzyme. Why is this important? It is important because 3HSD produces a weaker steroid by removing the highly important 3-keto group on the active steroid molecule. It this case it produces what are known as weak steroid “diols”. 3HSD is present in high amounts in muscle tissue, and represents a sort of blocking wall for the steroid to get through before it is able to find its corresponding receptor in the cytosol of the cell. Mesterolone and DHT will be actively looking for 3HSD if you will, and as a result very little will find the receptor before being converted to weakly active steroids. This is why people do not gain a lot of muscle mass while taking DHT or Mesterolone. The 1-methlation may result in improving the oral bioavailability of Mesterolone, hence the fact that it is an oral drug, but it doesn’t do much to protect it from 3HSD.
      Masteron contains a 2-methylated derivative of DHT. Unlike the 1-methylation of Mesterolone, this alteration doesn’t effectively protect the steroid during oral dosing. This is why we only see Masteron as an injectable medication. However, shifting the methyl group from the 1 to the 2 position on the steroid backbone very effectively prevents conversion by 3HSD. As a result, the steroid is well equipped to enter the cell and break through the defensive line of 3HSD enzymes. It will reach the cytosolic androgen receptor in high concentrations, and because of this may impart a measurable tissue-building effect. So the bottom line is that while both may help improve the look of hardness to the muscles during contest preparations, only Masteron is actually going to offer a strong effect in muscle tissue itself. This means the potential for much more muscle size and strength gains during building phases of training, and at the very least a greater level of muscle preservation during cutting phases of training (the latter due to anabolic action in muscle helping to counter the catabolic effects of calorie restriction). These two drugs illustrate well the fact that categorizing the actions of steroids based on the three derivative bases (testosterone, nandrolone, and dihydrotestosterone) is not a highly accurate practice. So the next time someone tells you “This is a DHT derivative… so”, you can tell them “So what? I want to know what THIS steroid does, not DHT!”

    15. Thanks Hatebreed thanked for this post
      Likes Hatebreed, HustleHard, babybull34 liked this post
    16. ----
    17. #7
      BOP VETERAN
      is Low test lots of primo
       
      I am:
      atwork
       

      Join Date
      Aug 2015
      Posts
      4,777
      Post Thanks / Like
      Rep Power
      56679
      So when it comes to a cycle like let's say
      test
      Primo
      Proviron
      Nppor deca I would choose the proviron over masteron in that line the mast and proviron give a very similar feel and look to me it's a waste

    18. Thanks babybull34 thanked for this post
      Likes babybull34 liked this post
    19. ----
    20. #8
      BOP VETERAN
      is Low test lots of primo
       
      I am:
      atwork
       

      Join Date
      Aug 2015
      Posts
      4,777
      Post Thanks / Like
      Rep Power
      56679
      So when it comes to a cycle like let's say
      test
      Primo
      Proviron
      Nppor deca I would choose the proviron over masteron in that line the mast and proviron give a very similar feel and look to me it's a waste

    21. ----
    22. #9
      BOP VETERAN
      This user has no status.
       
      I am:
      ----
       
      Primemuscle's Avatar
      Join Date
      Nov 2017
      Posts
      6,950
      Post Thanks / Like
      Rep Power
      56297
      Quote Originally Posted by babybull34 View Post
      Great post, HB. And Ski, I agree with you. The DHT-based compounds have always given the look I seek.

      One point of contention with the info posted though. Primo is a DHB, like EQ and 1-Test Cyp, not a DHT compound like Winstrol, Anavar, and Anadrol.
      Actually BB I was looking into 1-test cyp and even though it’s name has DHB in it, it’s actually a DHT.

      1-testosterone (dihydroboldenone), or DHB for short, is an anabolic steroid that has some unique properties of interest to bodybuilders. Interestingly, in spite of the fact that the name can be confusing, in no way is DHB testosterone. In fact, it is simply the 5alpha reduced form of Equipoise (boldenone), which acts in a completely different way. Therefore, you can think of it as a dihydrotestosterone (DHT) version of equipoise.

      Rest of profile is here: 1-testosterone (dihydroboldenone) - Evolutionary.org


      Sent from my iPhone using Tapatalk
      BE PART OF THE BEST
      XTLABS CORP.

      [email protected]
      [SIGPIC][/SIGPIC]

    23. Thanks Zeus-Sr thanked for this post
      Likes Zeus-Sr liked this post
    24. ----
    25. #10
      Senior Member
      This user has no status.
       
      I am:
      ----
       
      Zeus-Sr's Avatar
      Join Date
      Dec 2017
      Posts
      708
      Post Thanks / Like
      Rep Power
      2999
      Primemuscle so your saying 1test cyp is a a dht or the analogy is that it's like the dht version of EQ but it acts as a dhb

      do you think Primo is dhb or dht? BabyBull walked me through why it is a dhb and not a dht. I always thought it was a dht

      I am not sure why there is no consistent agreement on what they are - someone who thinks a compound is a dht and adds a dhb to the stack could be coming up with a less than par cycle

      Primemuscle and BabyBull you two are some of the most insightful people on compounds. I need to have you both agree what Primo is LOL
      Last edited by Zeus-Sr; 03-15-2018 at 07:55 PM.

    26. Thanks Primemuscle thanked for this post
      Likes Primemuscle liked this post
    27. ----
    Page 1 of 2 12 LastLast

    Similar Threads

    1. AAS Frontloading Explained
      By PAiN in forum Anabolic Steroid Discussion
      Replies: 98
      Last Post: 12-19-2022, 11:03 AM
    2. Sarms explained in detail !
      By Hatebreed in forum HGH / IGF / SLIN / MGF & All Peptides
      Replies: 0
      Last Post: 10-28-2017, 04:35 PM
    3. Orals and liver toxicity explained.
      By Hatebreed in forum Anabolic Steroid Discussion
      Replies: 4
      Last Post: 10-28-2017, 03:34 AM
    4. how can this be explained ?
      By mk86 in forum HGH / IGF / SLIN / MGF & All Peptides
      Replies: 7
      Last Post: 01-15-2017, 01:30 PM

    Tags for this Thread

    Bookmarks

    Posting Permissions

    • You may not post new threads
    • You may not post replies
    • You may not post attachments
    • You may not edit your posts
    •