Melanotan II - benefits without the sides

[Johnjuanb1]

I've researched MT2 in a variety of ways. What I have found works best in order to avoid the visibility of once invisible moles, and to limit nausea, while still getting darker than dark, and an insane sex drive increase is to research 250mcg with a meal right before going in a tanning bed for a few minutes, and preferably post workout and close to bed time. Having food in your stomach will reduce nausea. After time , your body adapts to MT2 and any nausea subsides. The levels of melanin increase in the blood stream with each subsequent dosing. Tanning increases the rate at which you darken. It's the uv exposure that stimulates the darkening of melanin. Low doses of 250mcg per subQ injection still builds up in your system but moles do not darken and it still gives the user crazy erections and increased sex drive. The same goes for women in regards to increased blow flow to the genitalia and sex drive increase.


This is one of my favorite peptides to research.



Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.

AuthorsWessells H, et al. Show all Journal
Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9.


Abstract


We review our experience with Melanotan II, a non-selective melanocortin receptor agonist, in human subjects with erectile dysfunction (ED). Melanotan II was administered to 20 men with psychogenic and organic ED using a double-blind placebo-controlled crossover design. Penile rigidity was monitored for 6 h using RigiScan. Level of sexual desire and side effects were reported with a questionnaire. In the absence of sexual stimulation, Melanotan II led to penile erection in 17 of 20 men. Subjects experienced a mean of 41 min Rigiscan tip rigidity>80%. Increased sexual desire was reported after 13/19 (68%) doses of Melanotan II vs 4/21 (19%) of placebo (P<0.01). Nausea and yawning were frequently reported side effects due to Melanotan II; at a dose of 0.025 mg/kg, 12.9% of subjects had severe nausea. We conclude that Melanotan II is a potent initiator of penile erection in men with erectile dysfunction. Our findings warrant further investigation of melanocortin agonists and antagonists on penile erection. International Journal of Impotence Research (2000) 12, Suppl 4, S74-S79.


PMID 11035391 [PubMed - indexed for MEDLINE]

[Dont wanna be old]

Good read JJB1 and thank you .
I always took before bed and knew feeling ill inside meant it was MT2 .
Your recommendation sounds so much better .
DWBO

[Johnjuanb1]

Good read JJB1 and thank you .
I always took before bed and knew feeling ill inside meant it was MT2 .
Your recommendation sounds so much better .
DWBO
Sometimes I get stupid and dose it high because it tends to increase my sex drive a lot more. :D

[Johnjuanb1]

The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats.

Authors
Banno R1, Arima H, Sato I, Hayashi M, Goto M, Sugimura Y, Murase T, Oiso Y.
Author information
Journal
Peptides. 2004 Aug;25(8):1279-86.


Abstract


Effects of peripheral administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity and glucose tolerance were examined in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Subcutaneous administration of MTII with osmotic mini-pumps decreased food intake and body weight in OLETF rats. MTII group showed more sensitivity to insulin compared with that allowed to eat ad libitum or pair-fed group in insulin tolerance tests on day 9. MTII group also showed significantly lower glucose values than ad libitum group in glucose tolerance tests on days 11 and 23. Thus, MTII increased insulin sensitivity and improved glucose tolerance in OLETF rats.

[Rambo]

I always lile dosing it before bed. I rarely ever tan, I held my tan from the summer on once a week injection of 200-300mcgs.

[Johnjuanb1]

I always lile dosing it before bed. I rarely ever tan, I held my tan from the summer on once a week injection of 200-300mcgs.
I agree. I haven't tanned in over a month and I'm still darker than Obama.

[enrod]

I noticed skin spots soon after uses Melanotan II, you ever have this issue?

[Johnjuanb1]

I noticed skin spots soon after uses Melanotan II, you ever have this issue?
Apparently, we all have moles that aren't visible to the baked eye. When melanin production is increased the invisible moles take on color and become visible.
I have found by keeping dose low at 250mcg this isn't an issue. When I used doses of 1mg it became noticeable.

[Johnjuanb1]

Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.

Authors
Dorr RT1, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME.
Author information
Journal
Life Sci. 1996;58(20):1777-84.


Affiliation
Abstract
A pilot phase I study was conducted with a cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH). The lactam-bridged molecule, called Melanotan-II (MT-II), has the structure Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 alpha-MSH4-10-NH2 (MT-II) and has superpotent melanotropic activity in vitro. A single-blind, alternating day (saline or MT-II), placebo-controlled trial was conducted in 3 normal male volunteers at the starting dose of 0.01 mg/kg of MT-II. Subcutaneous injections of MT-II or saline were given daily (Monday-Friday) for 2 consecutive weeks. Two subjects were escalated by 0.005 mg/kg increments to 0.03 mg/kg and one to 0.025 mg/kg. The 0.03 mg/kg dose produced Grade II somnolence and fatigue in one of two subjects (WHO standards). Mild nausea, not requiring antiemetic treatment, was reported at most MT-II dose levels. A stretching and yawning complex appeared to correlate with the onset of spontaneous, penile erections which were intermittently experienced for 1-5 hours after MT-II dosing, depending on the MT-II dose. Two subjects had increased pigmentation in the face, upper body and buttock, as measured by quantitative reflectance and by visual perception 1 week after MT-II dosing ended. These results demonstrate that MT-II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection. The recommended single MT-II dose for future Phase I studies is 0.025 mg/kg/day.

[masteratarms]

Thank you for posting brother

[Johnjuanb1]

Thank you for posting brother
You're welcome :)

[crazylegs80]

Thanks JJ, I quit using MT2 because I got tired of the GI upset. I just ordered 2 bottles to research from Superior and will be trying it the way you explained.

[Johnjuanb1]

Thanks JJ, I quit using MT2 because I got tired of the GI upset. I just ordered 2 bottles to research from Superior and will be trying it the way you explained.
Last night I took a high dose of melanotan at 1mg. I always drink a lot of water so I get up
to urinate a lot at night but I had an erection every time I got up. Haha had to get creative to pee.

[crazylegs80]

Nice, I'm getting used to that from the test/tren/masteron/caber that I'm on now! I ordered and have a couple bottles coming, thanks again... I used the jj50 discou t code.

[Johnjuanb1]

Nice, I'm getting used to that from the test/tren/masteron/caber that I'm on now! I ordered and have a couple bottles coming, thanks again... I used the jj50 discou t code.
Thank you very much for using my code! I appreciate it! :)

[crazylegs80]

Thank you very much for using my code! I appreciate it! :)

No problem! Pack already landed today, research starts tomorrow.

[Elvia1023]

No problem! Pack already landed today, research starts tomorrow.

Great. Let us know how you get on. Just remember to start very low in dose and build up over time.