Cabergoline (CABER)

[PAiN]

Cabergoline (aka Dostinex)
(1-[(6-allelylergolin-8 beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethyl-urea)

Cabergoline (pronounced ca-ber-goe-leen) is a long acting dopamine agonist which acts mainly on the D2 receptors. It is used to treat different types of medical problems that may occur when the body produces an excess of the hormone prolactin. It can also be used to treat menstrual problems in women, fertility problems in both men and women, and it also helps treat pituitary prolactinomas (pituitary gland tumors). Cabergoline is also reported to have some efficacy in patients with Nelson's syndrome and Cushing's disease, but data are available only for limited case reports.

Cabergoline works by signaling the brain to stop the pituitary gland from producing and releasing the prolactin hormone. It is usually used for periods of up to six months after prolactin levels return to normal. You can of course start using it again if high prolactin symptoms reappear later. Prolactin is a single chain protein hormone, similar to growth hormone, that stimulates the secretion of milk by women. Prolactin also effects male libido by preventing erections.

Below is a study done by the University of Naples in Italy, it compares treatment with cabergoline to bromocriptine.
This study evaluated the effects of chronic treatment with cabergoline (CAB), a new, potent and long-lasting ergoline-derived dopamine agonist, on seminal fluid parameters and sexual and gonadal function in hyperprolactinemic males in comparison with the effect of bromocriptine (BRC) treatment. Seventeen males with macroprolactinoma were treated with CAB at a dose of 0.5-1.5 mg/week (n = 7), or BRC at a dose of 5-15 mg/day (n = 10) for 6 months. Baseline prolactin (PRL) was 925.7 +/- 522.6 microg/l in the CAB-treated group and 1059.4 +/- 297.6 microg/l in the BRC-treated group. All the patients suffered from libido impairment, ten from reduced sexual potency, and six had infertility. In five patients provocative bilateral galactorrhea was found. Seminal fluid analysis, functional seminal tests and penis rigidity and tumescence, measured by nocturnal penile tumescence (NPT) using Rigiscan equipment, were assessed before and after 1, 3 and 6 months of CAB or BRC treatment. Hormone profiles were assessed before and after 15, 30, 60, 90 and 180 days of both treatments. Before treatment, all patients had a low sperm count with oligoasthenospermia, reduced motility and rapid progression with an abnormal morphology and decreased viability, and a low number of erections. After 1 month, serum PRL levels were significantly reduced in both groups of patients (20.6 +/- 6.6 microg/l during CAB and 256.3 +/- 115.1 microg/l during BRC treatment) and were normalized after 6 months in all patients (CAB: 7.9 +/- 2.2 microg/l; BRC: 16.7 +/- 1.8 microg/l). After 6 months, a significant increase of number, total motility, rapid progression and normal morphology was recorded in patients treated with both CAB and BRC. An increase in the number of erections during the first 3 months of both treatments was noted by NPT. However, the improvements in seminal fluid parameters and sexual function were more evident and rapid in patients treated with CAB. The number of erections was normalized after 6 months of treatment in all patients submitted to CAB treatment, and in all patients but one treated by BRC. In addition, a significant increase of serum testosterone (from 3.7 +/- 0.3 to 5.3 +/- 0.2 microg/l) and dihydrotestosterone (from 0.4 +/- 0.1 to 1.1 +/- 0.1 nmol/l) was recorded. At the beginning of treatment, mild side-effects were recorded in two patients after CAB and mild-to-moderate side-effects in five patients after BRC administration. The treatment with CAB normalized PRL levels, improving gonadal and sexual function and fertility in males with prolactinoma, earlier than did BRC treatment, providing good tolerability and excellent patient compliance to medical treatment. Cabergoline is normally used were treatment with bromocriptine has failed.

The dose of cabergoline will vary do to the use it is needed for. The following information includes only the average doses of cabergoline in oral dose form. For high prolactin levels or pituitary tumors use 0.25mg/2xwk. This dose can be increased every four weeks if needed because of high sustaining prolactin levels. Usually no more than 1mg/2xwk is needed. The reason for the four week waiting period before adjusting the dose is due to the long half life of the drug. Unlike bromo which should be dosed twice a day, cabergoline is usually dosed once or twice a week.

Men may get another added bonus when using cabergoline, as it has been found to substantially raise the chances of multiple orgasms in males during sex. Some men on the drug reported to have numerous multiple orgasms in rapid succession. In one study done by M. Schedlowski involved 60 male subjects between the ages of 20 to 30. It was found that they normally needed a break of approximately 20 minutes between sessions of sex. After receiving treatment with cabergoline they were able to have several orgasms within a span of a few minutes. Schedlowski said the drug raised the libido to enable the male to orgasm again more quickly. This is do to the fact that it reduces prolactin levels which is produced by men at the point of orgasm.

Some of the most common side effects you may encounter when using this drug are abdominal pain, or vertigo (the feeling that you are weightless or objects are moving around you). Other side effects like constipation, headaches, nausea and weakness may occur, but will most likely stop after your body gets use to the drug. Some of the less common side effects are a change in vision, dizziness, feeling faint when standing up after sitting or lying down, loss of appetite, loss or gain in weight, your hands, feet, or legs may swell up, and rapid heartbeat. Other less common sides include burning, itching or a stinging feeling of the skin, diarrhea, cotton mouth, muscle and joint pain, sore throat, trouble sleeping and a runny nose. Most dopamine drugs are well tolerated by most so the above mentioned side effects are rare. To help prevent some sides, take your dose with food.

Some symptoms of a possible overdose include fainting, hallucinations, lightheadedness, abnormally fast heart rate, and stuffy nose.

An interaction may occur if you use cabergoline with any anti-psychotic medicine or metoclopramide (used to treat stomach problems). Cabergoline should not be used if you suffer from the ailments such as untreated high blood pressure, cabergoline usually decreases blood pressure but at times it may increase it maken your condidtion worse. Also if you suffer from mild to severe liver disease, cabergoline may make you condition worse. In this case a lower dose may be all that is required.

[PAiN]

Dostinex
DESCRIPTION

DOSTINEX Tablets contain cabergoline, a dopamine receptor agonist. The chemical
name for cabergoline is 1-[(6-allylergolin-8?-yl)-carbonyl]-1-[3-(dimethylamino)propyl]3-
ethylurea. Its empirical formula is C26H37N5O2, and its molecular weight is 451.62. The
structural formula is as follows:


Cabergoline is a white powder soluble in ethyl alcohol, chloroform, and N, Ndimethylformamide
(DMF); slightly soluble in 0.1N hydrochloric acid; very slightly
soluble in n-hexane; and insoluble in water.

DOSTINEX Tablets, for oral administration, contain 0.5 mg of cabergoline. Inactive
ingredients consist of leucine, USP, and lactose, NF.

CLINICAL PHARMACOLOGY
Mechanism of Action: The secretion of prolactin by the anterior pituitary is mainly
under hypothalamic inhibitory control, likely exerted through release of dopamine by
tuberoinfundibular neurons. Cabergoline is a long-acting dopamine receptor agonist with
a high affinity for D2 receptors. Results of in vitro studies demonstrate that cabergoline
exerts a direct inhibitory effect on the secretion of prolactin by rat pituitary lactotrophs.
Cabergoline decreased serum prolactin levels in reserpinized rats. Receptor-binding
studies indicate that cabergoline has low affinity for dopamine D1, a1-and a2-adrenergic,
and 5-HT1- and 5-HT2-serotonin receptors.

Clinical Studies: The prolactin-lowering efficacy of DOSTINEX was demonstrated in
hyperprolactinemic women in two randomized, double-blind, comparative studies, one
with placebo and the other with bromocriptine. In the placebo-controlled study (placebo


n=20; cabergoline n=168), DOSTINEX produced a dose-related decrease in serum
prolactin levels with prolactin normalized after 4 weeks of treatment in 29%, 76%, 74%
and 95% of the patients receiving 0.125, 0.5, 0.75, and 1.0 mg twice weekly respectively.

In the 8-week, double-blind period of the comparative trial with bromocriptine
(cabergoline n=223; bromocriptine n=236 in the intent-to-treat analysis), prolactin was
normalized in 77% of the patients treated with DOSTINEX at 0.5 mg twice weekly
compared with 59% of those treated with bromocriptine at 2.5 mg twice daily.
Restoration of menses occurred in 77% of the women treated with DOSTINEX,
compared with 70% of those treated with bromocriptine. Among patients with
galactorrhea, this symptom disappeared in 73% of those treated with DOSTINEX
compared with 56% of those treated with bromocriptine.

Pharmacokinetics

Absorption: Following single oral doses of 0.5 mg to 1.5 mg given to 12 healthy adult
volunteers, mean peak plasma levels of 30 to 70 picograms (pg)/mL of cabergoline were
observed within 2 to 3 hours. Over the 0.5-to-7 mg dose range, cabergoline plasma levels
appeared to be dose-proportional in 12 healthy adult volunteers and nine adult
parkinsonian patients. A repeat-dose study in 12 healthy volunteers suggests that steady-
state levels following a once-weekly dosing schedule are expected to be twofold to
threefold higher than after a single dose. The absolute bioavailability of cabergoline is
unknown. A significant fraction of the administered dose undergoes a first-pass effect.
The elimination half-life of cabergoline estimated from urinary data of 12 healthy
subjects ranged between 63 to 69 hours. The prolonged prolactin-lowering effect of
cabergoline may be related to its slow elimination and long half-life.

Distribution: In animals, based on total radioactivity, cabergoline (and/or its metabolites)
has shown extensive tissue distribution. Radioactivity in the pituitary exceeded that in
plasma by >100-fold and was eliminated with a half-life of approximately 60 hours. This
finding is consistent with the long-lasting prolactin-lowering effect of the drug. Whole
body autoradiography studies in pregnant rats showed no fetal uptake but high levels in
the uterine wall. Significant radioactivity (parent plus metabolites) detected in the milk of
lactating rats suggests a potential for exposure to nursing infants. The drug is extensively
distributed throughout the body. Cabergoline is moderately bound (40% to 42%) to
human plasma proteins in a concentration-independent manner. Concomitant dosing of
highly protein-bound drugs is unlikely to affect its disposition.

Metabolism: In both animals and humans, cabergoline is extensively metabolized,
predominately via hydrolysis of the acylurea bond or the urea moiety. Cytochrome P-450
mediated metabolism appears to be minimal. Cabergoline does not cause enzyme
induction and/or inhibition in the rat. Hydrolysis of the acylurea or urea moiety abolishes
the prolactin-lowering effect of cabergoline, and major metabolites identified thus far do
not contribute to the therapeutic effect.

Excretion: After oral dosing of radioactive cabergoline to five healthy volunteers,
approximately 22% and 60% of the dose was excreted within 20 days in the urine and


f
Food-Drug Interaction

In 12 healthy adult volunteers, food did not alter cabergoline kinetics.

Pharmacodynamics

Dose response with inhibition of plasma prolactin, onset of maximal effect, and duration
of effect has been documented following single cabergoline doses to healthy volunteers

(0.05 to 1.5 mg) and hyperprolactinemic patients (0.3 to 1 mg). In volunteers, prolactin
inhibition was evident at doses >0.2 mg, while doses =0.5 mg caused maximal
suppression in most subjects. Higher doses produce prolactin suppression in a greater
proportion of subjects and with an earlier onset and longer duration of action. In 12
healthy volunteers, 0.5, 1, and 1.5 mg doses resulted in complete prolactin inhibition,
with a maximum effect within 3 hours in 92% to 100% of subjects after the 1 and 1.5 mg
doses compared with 50% of subjects after the 0.5 mg dose.
In hyperprolactinemic patients (N=51), the maximal prolactin decrease after a 0.6 mg
single dose of cabergoline was comparable to 2.5 mg bromocriptine; however, the
duration of effect was markedly longer (14 days vs 24 hours). The time to maximal effect
was shorter for bromocriptine than cabergoline (6 hours vs 48 hours).

In 72 healthy volunteers, single or multiple doses (up to 2 mg) of cabergoline resulted in
selective inhibition of prolactin with no apparent effect on other anterior pituitary
hormones (GH, FSH, LH, ACTH, and TSH) or cortisol.

INDICATIONS AND USAGE

DOSTINEX Tablets are indicated for the treatment of hyperprolactinemic disorders,
either idiopathic or due to pituitary adenomas.

CONTRAINDICATIONS

DOSTINEX Tablets are contraindicated in patients with uncontrolled hypertension or
known hypersensitivity to ergot derivatives.


WARNINGS

Dopamine agonists in general should not be used in patients with pregnancy-induced
hypertension, for example, preeclampsia and eclampsia, unless the potential benefit is
judged to outweigh the possible risk.

PRECAUTIONS
General: Initial doses higher than 1.0 mg may produce orthostatic hypotension. Care
should be exercised when administering DOSTINEX with other medications known to
lower blood pressure.

Postpartum Lactation Inhibition or Suppression: DOSTINEX is not indicated for the
inhibition or suppression of physiologic lactation. Use of bromocriptine, another
dopamine agonist for this purpose, has been associated with cases of hypertension,
stroke, and seizures.

Hepatic Impairment: Since cabergoline is extensively metabolized by the liver, caution
should be used, and careful monitoring exercised, when administering DOSTINEX to
patients with hepatic impairment.

Information for Patients: A patient should be instructed to notify her physician if she
suspects she is pregnant, becomes pregnant, or intends to become pregnant during
therapy. A pregnancy test should be done if there is any suspicion of pregnancy and
continuation of treatment should be discussed with her physician.

Drug Interactions: DOSTINEX should not be administered concurrently with D2antagonists,
such as phenothiazines, butyrophenones, thioxanthenes, or metoclopramide.

Carcinogenesis, Mutagenesis, Impairment of Fertility: Carcinogenicity studies were
conducted in mice and rats with cabergoline given by gavage at doses up to 0.98
mg/kg/day and 0.32 mg/kg/day, respectively. These doses are 7 times and 4 times the
maximum recommended human dose calculated on a body surface area basis using total
mg/m2/week in rodents and mg/m2/week for a 50 kg human.

[unclem]

nice post pain.

[supermansdaddy]

You are a mind reader. I really am not well versed in this compound and I need to be. Big thanks, Great post.

Peace and Love

[bufbiker]

One thing I've discovered is that dostinex doesn't inhibit progesterone conversion, so it is not really preventative. Arimidex seems to work much better in preventing the problems from arising to begin with.
So I see ai use as much more important than the use of dost, caber, prami etc. Of course I would have it on hand when running tren, deca, NPP etc.
Has that been anyone else's experience.

[BrotherIron]

One thing I've discovered is that dostinex doesn't inhibit progesterone conversion, so it is not really preventative. Arimidex seems to work much better in preventing the problems from arising to begin with.
So I see ai use as much more important than the use of dost, caber, prami etc. Of course I would have it on hand when running tren, deca, NPP etc.
Has that been anyone else's experience.

Not at all. AI are designed to inhibit estrogen not progesterone. That is exactly what dostinex, bromo, etc are designed for. You get gyno from Tren or Deca and an AI, like letro, a-sin, or a-dex will do nothing for you.

[Flathead]

Good read!!

[Shovel]

Not at all. AI are designed to inhibit estrogen not progesterone. That is exactly what dostinex, bromo, etc are designed for. You get gyno from Tren or Deca and an AI, like letro, a-sin, or a-dex will do nothing for you.


If your estro is kept in check, proges is less likely to arise. Those drugs (caber, dost, prami) are more of anti depressants. I would have them on hand in case of someone being prone to it.

Not mine, but a good read none the less.


I would like to clear up a few misconceptions about progesterone and gynecomastia.

Their is absolutely no steroid that aromatizes into progesterone. The reason for this is that progesteron does not have an aromatic A ring. So toss that myth out the window. Tren? Deca? Sorry but it just doesn't happen.

Now Tren and Deca bind pretty well to the PR. They are progestins in their own right without undergoing any structural changes, but their affinity is MUCH weaker than progesterone itself. Even more so when nandrolone is reduced by 5-alpha reductase into DHN. Their is a small chance of progestogenic activity that could aid in manifesting a mass in the mammry IF estrogen is present in supraphysiological amounts, without proper ratio to testosterone but I have never see a documented case of progestogenic gynecomastia. The reason for this is that the PR has two isoforms. The PR-A and PR-B. PR-B mediates stimulatory effects of progestins; PR-A which is bound with progestins or anti-progestins inhibits PR-B, and PR-A is ***inant,. The response to progesterone is determined by the relative expression of the two isoforms.

There is a direct relationship between the PR isoforms and steroid concentrations an this direct relationship suggests high progesterone concentrations, but this will induce the expression of PR-A, which represses transcription of PR-B, which in turn supresses PR function and progestin effect
With initial administration of nandrolone or it's dirivitives, I could see an expression of PR-B but a rapid rise in PR-A will ultimately supress the function of the PR. IMO, you would need a high ratio of the two before concerns, and this is a bit more of a possiblity with the begining of administration. In this time of vulnerability, rest assured in aromatase inhibitors as progesterone is an E2 agonist so the utilization of an AI will help. I personally don't think the concern is warranted though

Their are 4 combinations of hormones that cause gyno- Estrogen, Progesterone, Prolactin, and IGF. Nandrolone is a weak progestin, which agonizes the PRL, it also raises IGF. Progesterone induced gyno is not really of a concern given binding affinity to the PR and the mechanism of the two isoforms. The production of prolactin is a deffinate risk. Not only can it be an inductor for gyno along side estrogen, IGF, and pogesterone; this chance is increased as prolactn lowers testosterone. So you need to make sure to take proper precautions to not only keep estrogen in check, but prolactin as well.

Also, basically from what I've read on the matter, prolactin or progesterone will not cause gyno unless there is excess estrogen that has been aromatized in the body and already beginning the stages of gyno. It just adds on to the problem and brings with it lactation. Having said that, if you are on nonaromatizing compounds along with tren, you should not get gyno. If you are on winny (and anti-progestagenic) you will not get gyno. If you are on aromatizing compounds and you supplement with anti-e's and AI, you should not get gyno because your estrogen level will be in check therefore not causing excess estrogen for the progesterone to team up with. Its all starting to make a little more sense to me now. If any of you have any conflicting or additional information to this topic, please post it. I am in the process of adding the Tren E back in my cycle as soon as I feel comfortable that I have my gyno in check.

[BrotherIron]

If your estro is kept in check, proges is less likely to arise. Those drugs (caber, dost, prami) are more of anti depressants. I would have them on hand in case of someone being prone to it.

Not mine, but a good read none the less.


I would like to clear up a few misconceptions about progesterone and gynecomastia.

Their is absolutely no steroid that aromatizes into progesterone. The reason for this is that progesteron does not have an aromatic A ring. So toss that myth out the window. Tren? Deca? Sorry but it just doesn't happen.

Now Tren and Deca bind pretty well to the PR. They are progestins in their own right without undergoing any structural changes, but their affinity is MUCH weaker than progesterone itself. Even more so when nandrolone is reduced by 5-alpha reductase into DHN. Their is a small chance of progestogenic activity that could aid in manifesting a mass in the mammry IF estrogen is present in supraphysiological amounts, without proper ratio to testosterone but I have never see a documented case of progestogenic gynecomastia. The reason for this is that the PR has two isoforms. The PR-A and PR-B. PR-B mediates stimulatory effects of progestins; PR-A which is bound with progestins or anti-progestins inhibits PR-B, and PR-A is ***inant,. The response to progesterone is determined by the relative expression of the two isoforms.

There is a direct relationship between the PR isoforms and steroid concentrations an this direct relationship suggests high progesterone concentrations, but this will induce the expression of PR-A, which represses transcription of PR-B, which in turn supresses PR function and progestin effect
With initial administration of nandrolone or it's dirivitives, I could see an expression of PR-B but a rapid rise in PR-A will ultimately supress the function of the PR. IMO, you would need a high ratio of the two before concerns, and this is a bit more of a possiblity with the begining of administration. In this time of vulnerability, rest assured in aromatase inhibitors as progesterone is an E2 agonist so the utilization of an AI will help. I personally don't think the concern is warranted though

Their are 4 combinations of hormones that cause gyno- Estrogen, Progesterone, Prolactin, and IGF. Nandrolone is a weak progestin, which agonizes the PRL, it also raises IGF. Progesterone induced gyno is not really of a concern given binding affinity to the PR and the mechanism of the two isoforms. The production of prolactin is a deffinate risk. Not only can it be an inductor for gyno along side estrogen, IGF, and pogesterone; this chance is increased as prolactn lowers testosterone. So you need to make sure to take proper precautions to not only keep estrogen in check, but prolactin as well.

Also, basically from what I've read on the matter, prolactin or progesterone will not cause gyno unless there is excess estrogen that has been aromatized in the body and already beginning the stages of gyno. It just adds on to the problem and brings with it lactation. Having said that, if you are on nonaromatizing compounds along with tren, you should not get gyno. If you are on winny (and anti-progestagenic) you will not get gyno. If you are on aromatizing compounds and you supplement with anti-e's and AI, you should not get gyno because your estrogen level will be in check therefore not causing excess estrogen for the progesterone to team up with. Its all starting to make a little more sense to me now. If any of you have any conflicting or additional information to this topic, please post it. I am in the process of adding the Tren E back in my cycle as soon as I feel comfortable that I have my gyno in check.

That's very interesting but my personal exp has me believing otherwise. I had issues even with a strong AI like letro from the pharm. The problem was resoved when I added caber into the mix @ .5mg Every 3rd. I would also say you should run T3 if you run Tren b/c Tren affects your thyroid (TSH) levels.

[bufbiker]

Very interesting.

[Biggin]

Good read and post..

[unclem]

do anyone of you guys think estrogen gives muscle it size to a point? or no estrogen does not give no size to muscle and its size? just curious.

[Shovel]

Estrogen is crucial for growth. The right amount is the hard part. Too much and too little can be a problem...

[bufbiker]

I agree that some estrogen must be present or you'll dry out in the joints etc. In fact on simple cycles like test only I try not to use any ai if possible. Always have it on hand. But you add tren, deca etc into the mix an ai is a must if you wnat to be able to satisfy the old lady.

[casa]

Great post here guys.

[jandj0821]

GREAT post,

[mdr]

Very nice post

[unclem]

i think pains thread here should be a stickie.

[mdr]

I agree Unclem

[Ironworker]

Serum levels at 20-45nl/mg of estradiol are normal and provide all the anabolic effect estrogen can provide. The problem is knowing your estradiol level, which can only be measured through a blood test. Experimenting with AI's and SERM's are all we have unless you can afford a blood test every 2 weeks.

We know through scientific research that anastrozol (arimidex) at 1mg/day will reduce free estrogen by 50% in AAS-using males, averaging 600mg/wk of test. But 50% of what value? For gyno mitigation or protection, tamoxifen (Nolvadex) is the staple. And it helps normalize the HPTA. But it won't prevent other estrogen sides like bloat and SHBG suppression. Aromasin (Exemestane) at 15-25mg/day will suppress aromatization by 97% in AAS-using males averaging 600-1,000mg/wk of testosterone. But 97% of what amount? If we reduce estradiol to below 20nl/mg, we begin to reduce a percentage of muscular hypertrophy.

Longterm experimentation by each user is crucial in finding the proper dosing protocol. Vets in the game have some knowledge of what works for them and can be used as a starting point on similar cycles.

As far as prolactin induced through nandrolone-based steroids, there is plenty of anecdotal evidence that it rises to levels producing gyno. I've experienced it and have mitigated it with cabergoline at 1mg/e3days.

[halfApint]

Not at all. AI are designed to inhibit estrogen not progesterone. That is exactly what dostinex, bromo, etc are designed for. You get gyno from Tren or Deca and an AI, like letro, a-sin, or a-dex will do nothing for you.

exactly, always have caber on hand while using deca/tren especially for the first time. reps

caber also makes you blow huge loads!

[halfApint]

As far as prolactin induced through nandrolone-based steroids, there is plenty of anecdotal evidence that it rises to levels producing gyno. I've experienced it and have mitigated it with cabergoline at 1mg/e3days.

Few questions...

1) are you prone to prolactin sides?
2) when you run a compound that can cause prolactin sides, do you run caber e3d before you see side effects? or wait for them to come on...
3) what is your exp with prolactin sides with deca/tren?

for those who dont know, 1mg = 1000mcg since the caber I have generally seen comes in mcg dosages. oh, and it makes me blow huge loads. :)

[mdr]

Few questions...

1) are you prone to prolactin sides?
2) when you run a compound that can cause prolactin sides, do you run caber e3d before you see side effects? or wait for them to come on...
3) what is your exp with prolactin sides with deca/tren?

for those who dont know, 1mg = 1000mcg since the caber I have generally seen comes in mcg dosages. oh, and it makes me blow huge loads. :)

So far, I've been able to get away with .5 mg every three days. I really like caber a lot.

[Caligirl]

You read minds, I was just on the profiles "anabolic" to see it under Cabaser, but here I find you with it here.

Thank you!

[halfApint]

So far, I've been able to get away with .5 mg every three days. I really like caber a lot.

makes me blow HUGE loads bro! sorry for too much info

[mdr]

makes me blow HUGE loads bro! sorry for too much info

No offense-it is a nice side effect, no doubt!

[mopits]

this answered most of my ?'s THX

[johnnytats]

i didnt get gyno from tren .so im glad you cleared that up . so i dont need arimadex for tren cycle but i will if i ad low dose of test

[JayDiesel]

Ive always loved Caber! It makes you feel good all over lmao helps with the sex drive and takes the edge off when on Tren!

[paulthebodybuilder]

Sounds sick .. Gonna have to try

[bbcoach]

what other uses can you use this for?

[flip1972]

I'm prone to gyno with tren. In my experience no ai ever helped. But adding cabaser was a godsend

[HGH_King]

Its a very good post
I say this as a pharmaciest
:RnwxSzKYAo4QV47Y.jp

[Rickx]

So thinking about running another tren and test cycle lat time I ran 400mg tren E a week with 450 test E a week great cycle had 0 sides but I was running aromasten and caber with it...loved the cycle...wana do it again but can't find caber thats usa domestic...I have 1.5 mg left from old cycle...can I run w/o caber and only use as needed or should I hold off on cycle till I can find some or...ship from ero and risk the signature??? At a cross roads here what ya guys think
Ooo only side I had on the cycle was didnt trust my gf and broke it off lol fucking tren

[Primodaddy]

So thinking about running another tren and test cycle lat time I ran 400mg tren E a week with 450 test E a week great cycle had 0 sides but I was running aromasten and caber with it...loved the cycle...wana do it again but can't find caber thats usa domestic...I have 1.5 mg left from old cycle...can I run w/o caber and only use as needed or should I hold off on cycle till I can find some or...ship from ero and risk the signature??? At a cross roads here what ya guys think
Ooo only side I had on the cycle was didnt trust my gf and broke it off lol fucking tren


NOBODY has it USA domestic really? Either way ordering caber ain't going to get the cops at your door lol so chill brother and just order your shit :) And yes hold off till you have all supplies on hand.

[GearHeaded]

So thinking about running another tren and test cycle lat time I ran 400mg tren E a week with 450 test E a week great cycle had 0 sides but I was running aromasten and caber with it...loved the cycle...wana do it again but can't find caber thats usa domestic...I have 1.5 mg left from old cycle...can I run w/o caber and only use as needed or should I hold off on cycle till I can find some or...ship from ero and risk the signature??? At a cross roads here what ya guys think
Ooo only side I had on the cycle was didnt trust my gf and broke it off lol fucking tren

guys have run Tren and other 19 nors for decades without needing Caber. the fact that every average Joe gym rat that doesn't look like he lifts suddenly needs caber to run a small dose Tren cycle is some sort of modern day Internet forum phenomenon

no offense to you personally Rickx, was just using your post to make a point. of course you can run your cycle without Caber. heck add some Masteron to that cycle and you won't prob ever need caber any how

[Rickx]

guys have run Tren and other 19 nors for decades without needing Caber. the fact that every average Joe gym rat that doesn't look like he lifts suddenly needs caber to run a small dose Tren cycle is some sort of modern day Internet forum phenomenon

no offense to you personally Rickx, was just using your post to make a point. of course you can run your cycle without Caber. heck add some Masteron to that cycle and you won't prob ever need caber any how

Bro no offence taken to be real I am joe gym rat only rum 3 cycles now and im 187 lbs and like 13 14 % bf been lifting 5 years now but got real year ago...thank for the you tho bro

[Rickx]

NOBODY has it USA domestic really? Either way ordering caber ain't going to get the cops at your door lol so chill brother and just order your shit :) And yes hold off till you have all supplies on hand.

That signature for delivery is what trips me out

[GearHeaded]

That signature for delivery is what trips me out

it really shouldn't be a worry brother.

to put it in perspective I've been getting International packages I've had to sign for for at least 7 years.. never had a problem . in fact the mail man is so used to seeing these packages from Germany that require a signature that he don't care anymore and just sticks them in my mail box.

really its the least of your worries in this game. you should be more worried about wither your gear is legit and when you inject that shit into your body is it going to be full of toxins and kill you . or maybe it is legit high quality gear and you have some rare genetic issue and you inject the good shit in and you end up getting a blood clot stroke and dying..

come one man. real fear. don't fear the mail man and signing for a package lol

[Zeus-Sr]

There is a domestic bop sponsor that has caber - just need to know where to look.

Also just my opinion - I wouldn’t just take caber before even knowing I was prone to prolactin issues. Yes caber is a top choice to reduce prolactin but it also increases your dopamine levels. If you take caber for awhile your body’s ability to produce healthy levels of dopamine can be effected. Not having enough dopamine sucks because it’s the pleasure neurotransmitter.

personally I would have caber on hand - use p5p each day together with aromasin and see what happens. If you don’t get prolactin issues no need to mess with your dopamine levels unnecessarily.

Just my opinion

[Rickx]

it really shouldn't be a worry brother.

to put it in perspective I've been getting International packages I've had to sign for for at least 7 years.. never had a problem . in fact the mail man is so used to seeing these packages from Germany that require a signature that he don't care anymore and just sticks them in my mail box.

really its the least of your worries in this game. you should be more worried about wither your gear is legit and when you inject that shit into your body is it going to be full of toxins and kill you . or maybe it is legit high quality gear and you have some rare genetic issue and you inject the good shit in and you end up getting a blood clot stroke and dying..

come one man. real fear. don't fear the mail man and signing for a package lol

Ya your right bro...

[Rickx]

There is a domestic bop sponsor that has caber - just need to know where to look.

Also just my opinion - I wouldn’t just take caber before even knowing I was prone to prolactin issues. Yes caber is a top choice to reduce prolactin but it also increases your dopamine levels. If you take caber for awhile your body’s ability to produce healthy levels of dopamine can be effected. Not having enough dopamine sucks because it’s the pleasure neurotransmitter.

personally I would have caber on hand - use p5p each day together with aromasin and see what happens. If you don’t get prolactin issues no need to mess with your dopamine levels unnecessarily.

Just my opinion

Shit bro I didnt know that

[meatneck71]

One thing I've discovered is that dostinex doesn't inhibit progesterone conversion, so it is not really preventative. Arimidex seems to work much better in preventing the problems from arising to begin with.
So I see ai use as much more important than the use of dost, caber, prami etc. Of course I would have it on hand when running tren, deca, NPP etc.
Has that been anyone else's experience.


I can firsthand tell you that A-dex doesn't do squat when it comes to prolactin issues, especially from tren. Oh, how I wish I had caber on hand, and perhaps I wouldn't have needed to get that surgery...

[MR.PUMP]

wow. very interinteresting. Good info!

[Thahulk]

Good read on caber.

[Devil1]

Exactly what I was looking for! Good read!

[metromuscle]

Need some advice. I've been taking 0.25 every day for quite some time (app. year) and it definitely does the trick. With the high price $$$ of caber, would I possibly be able to do the 0.25 eod? Any other dosage arrangement? Thanks.