Apex Peptides
07-09-2015, 02:59 AM
This is a very basic breakdown of the rationale behind a very common peptide combination: MOD GRF 1-29 (http://www.apexpeptides.com/combo-mod-grf-1-29-cjc-1295-w-o-dac-2mg-ghrp-6-5mg/) and GHRP-6 (http://www.apexpeptides.com/ghrp-6-5mg-buy-1-get-1-free/) or GHRP-2. (http://www.apexpeptides.com/ghrp-6-5mg-buy-1-get-1-free/)This little write up is from my own individual perspective with the help of some sources. This info is not to be taken as factual. If someone has additional information, edits or strongly disagrees with any of the material I presented, please speak up. I'm certainly not the resident expert in the science of peptides and I'm always open to learn.
Growth Hormone Releasing Peptide (GHRP-2 o (http://www.apexpeptides.com/ghrp-2-5mg-buy-1-get-1-free/)r GHRP-6) (http://www.apexpeptides.com/ghrp-6-5mg-buy-1-get-1-free/)administered concomitantly with a Growth Hormone Releasing Hormone (GHRH);namely MOD GRF 1-29 ak (http://www.apexpeptides.com/mod-grf-1-29-2mg-buy-1-get-1-free/)a “CJC-1295 without drug affinity complex or DAC,” is a very popular and effective peptide combination. This is an excellent combination because the two peptides work synergistically. The GHRP releases a GH pulse while the GHRH intensifies the pulse. In short, they basically work together to release and amplify a natural pulse of GH produced in the pituitary gland. This teamwork more than doubles the effect of either peptide on its own.
MOD GRF 1-29 is a (http://www.apexpeptides.com/combo-mod-grf-1-29-cjc-1295-w-o-dac-2mg-ghrp-6-5mg/) synthetic human GHRH analogue, quite similar to DAC conjugated CJC-1295, however, without drug affinity complex (DAC) attached. The modifications of removing the DAC from CJC-1295 were made to render it much more stable and effective. MOD GRF 1-29 is largely known to extensively increase plasma GH concentrations and IGF-1 levels for sustained amounts of time. While it seems MOD GRF 1-29 is certainly more popular than CJC-1295 DAC, (http://www.apexpeptides.com/cjc-1295-dac-2mg-buy-1-get-1-free/) both peptides produce promising results.
GHRP-6 presents effects that act on ghrelin receptors often eliciting intense hunger and increased gastric motility. It should be noted that some studies have revealed incidents in which cortisol and prolactin have been mildly elevated when GHRP-6 was involved.
GHRP-2, a second generation peptide, provokes an even more intense GH release than GHRP-6. This increased GH release however, isn’t accompanied by increased gastric motility and hunger. This is because there is little to no stimulation of ghrelin receptors. Like GHRP-6, studies have suggested that GHRP-2 may slightly affect prolactin and cortisol levels.
The most common method of utilizing the combination is via augmented recurring or pulsatile dosing throughout the day. Moreover, data suggest that single daily doses are far less effective than multiple daily doses of this combination. In vivo testing suggests that doses of 100 mcg of Mod GRF 1-29 together with 100-200 mcg of a GHRP administered t.i.d., sub-Q preferably 30 minutes ante cibum produce the greatest results. GHRH + GHRP (http://www.apexpeptides.com/combo-mod-grf-1-29-cjc-1295-w-o-dac-2mg-ghrp-2-5mg/)treatment may increase muscle strength, muscle mass, fatloss and hypertrophy. In addition, an optimized protocol of GHRH + GHRP a (http://www.apexpeptides.com/ghrp-6-cjc-1295-dual-blend-buy-1-get-1-free/)dministration would likely attenuate some of the effects of aging on skeletal muscle function in older persons and athletes alike.
http://brotherhoodofpain.com/attachment.php?attachmentid=4753&stc=1 (http://www.apexpeptides.com/combo-mod-grf-1-29-cjc-1295-w-o-dac-2mg-ghrp-6-5mg/)
Sources
Pulsatile Secretion of Growth Hormone (GH) Persists duringContinuous Stimulation by CJC-1295, a Long- Acting GH-Releasing Hormone Analog,Madalina Ionescu and Lawrence A. Frohman, The Journal of Clinical Endocrinology& Metabolism 2006 91(12):4792-4797 (tel:4792-4797)
Neuronal M3muscarinic acetylcholine receptors are essential for somatotroph proliferationand normal somatic growth, Dinesh Gautam, PNAS April 14, 2009 vol. 106 no. 15
Growth Hormone Releasing Peptide (GHRP-2 o (http://www.apexpeptides.com/ghrp-2-5mg-buy-1-get-1-free/)r GHRP-6) (http://www.apexpeptides.com/ghrp-6-5mg-buy-1-get-1-free/)administered concomitantly with a Growth Hormone Releasing Hormone (GHRH);namely MOD GRF 1-29 ak (http://www.apexpeptides.com/mod-grf-1-29-2mg-buy-1-get-1-free/)a “CJC-1295 without drug affinity complex or DAC,” is a very popular and effective peptide combination. This is an excellent combination because the two peptides work synergistically. The GHRP releases a GH pulse while the GHRH intensifies the pulse. In short, they basically work together to release and amplify a natural pulse of GH produced in the pituitary gland. This teamwork more than doubles the effect of either peptide on its own.
MOD GRF 1-29 is a (http://www.apexpeptides.com/combo-mod-grf-1-29-cjc-1295-w-o-dac-2mg-ghrp-6-5mg/) synthetic human GHRH analogue, quite similar to DAC conjugated CJC-1295, however, without drug affinity complex (DAC) attached. The modifications of removing the DAC from CJC-1295 were made to render it much more stable and effective. MOD GRF 1-29 is largely known to extensively increase plasma GH concentrations and IGF-1 levels for sustained amounts of time. While it seems MOD GRF 1-29 is certainly more popular than CJC-1295 DAC, (http://www.apexpeptides.com/cjc-1295-dac-2mg-buy-1-get-1-free/) both peptides produce promising results.
GHRP-6 presents effects that act on ghrelin receptors often eliciting intense hunger and increased gastric motility. It should be noted that some studies have revealed incidents in which cortisol and prolactin have been mildly elevated when GHRP-6 was involved.
GHRP-2, a second generation peptide, provokes an even more intense GH release than GHRP-6. This increased GH release however, isn’t accompanied by increased gastric motility and hunger. This is because there is little to no stimulation of ghrelin receptors. Like GHRP-6, studies have suggested that GHRP-2 may slightly affect prolactin and cortisol levels.
The most common method of utilizing the combination is via augmented recurring or pulsatile dosing throughout the day. Moreover, data suggest that single daily doses are far less effective than multiple daily doses of this combination. In vivo testing suggests that doses of 100 mcg of Mod GRF 1-29 together with 100-200 mcg of a GHRP administered t.i.d., sub-Q preferably 30 minutes ante cibum produce the greatest results. GHRH + GHRP (http://www.apexpeptides.com/combo-mod-grf-1-29-cjc-1295-w-o-dac-2mg-ghrp-2-5mg/)treatment may increase muscle strength, muscle mass, fatloss and hypertrophy. In addition, an optimized protocol of GHRH + GHRP a (http://www.apexpeptides.com/ghrp-6-cjc-1295-dual-blend-buy-1-get-1-free/)dministration would likely attenuate some of the effects of aging on skeletal muscle function in older persons and athletes alike.
http://brotherhoodofpain.com/attachment.php?attachmentid=4753&stc=1 (http://www.apexpeptides.com/combo-mod-grf-1-29-cjc-1295-w-o-dac-2mg-ghrp-6-5mg/)
Sources
Pulsatile Secretion of Growth Hormone (GH) Persists duringContinuous Stimulation by CJC-1295, a Long- Acting GH-Releasing Hormone Analog,Madalina Ionescu and Lawrence A. Frohman, The Journal of Clinical Endocrinology& Metabolism 2006 91(12):4792-4797 (tel:4792-4797)
Neuronal M3muscarinic acetylcholine receptors are essential for somatotroph proliferationand normal somatic growth, Dinesh Gautam, PNAS April 14, 2009 vol. 106 no. 15