ACE - 031 Tell me about it.

[wsnake]

Having a quick look at some peptides I hadn't heard very much about and come across this one ACE-031. Cant seem to find out much about it from first hand users, which is very strange when the company that developed it published this sort of info.


ACE-031 was well tolerated at all dose levels and demonstrated a linear pharmacokinetic profile with an average half-life ranging from 10-15 days
Single doses of ACE-031 at 1 mg/kg and 3 mg/kg produced dose-dependent increases in lean body mass measured by dual energy X-ray absorptiometry (DXA) as early as day 15 that were sustained through day 57
Subjects given single doses of placebo had a 0.2% decrease in lean body mass at day 57 compared to a 2.4% increase in subjects receiving 1 mg/kg ACE-031 and a 2.6% increase in subjects receiving 3 mg/kg ACE-031
Subjects given single doses of placebo had a 0.2% decrease in muscle volume assessed by MRI at day 29 compared to a 3.5% increase in subjects receiving 1 mg/kg ACE-031 and 5% increase in subjects receiving 3 mg/kg ACE-031
ACE-031 favorably affected biomarkers of fat mass (increased adiponectin and decreased leptin) and bone formation and resorption (increased bone-specific alkaline phosphatase (BSAP) and decreased C-terminal type 1 collagen telopeptide (CTX)) at doses of 1 and 3 mg/kg

The way I read the quote is "a single dose @ 1mg/kg resulted in 2.4% increase in LBM at 57days from application".

Then another study, once again buy the manufacturer shows solid support for the first study.

5143

Why is this stuff not more common? Can anyone share experience with Myostatin Inhibitors?

[mnmsnowbeast]

Not sure but a lot of people who have investigated these compounds follistatin 344 and ACE-31 myostatin HMP both peptides at 1mg vials are around $185 bucks for roughly a 10 day blast,and some people blast the whole 1mg vial at once,both compounds produce rapid fat loss,and follistatin untagged has shown some very good gains in strength and if you eat enough calories a day show muscle increase of as much as a 1lb per day. But most of these claims come from lab tests on mice and monkeys,and there myostatin system is nothing llike ours,in fact a lot of animals don't have myostatin levels at all,but we do,and we need them in place to save our tendons and attachments,now one vial of 1mg of follistatin will most likely not hurt your connective tissues a lot,but a few months or a year,its up for grabs,it is very interesting.

[johnnyb1635]

I'll be running an experiment on my rats starting tomorrow on ace-031. I've done a great deal of research into the subject, and I've noticed that with all the studies done on myostatin is that it's best to try and halt the production of myostatin all together rather than modulate the receptors. In essence, it's better to eliminate the myostatin in the body rather than inject the ace031 to bind to the receptors. Here's where my research really got my attention.

You our know what one of the most powerful compounds out there is to reduce the production of myostatin?

Creatine.... Yes... Good ol tried and true Creatine.

My my plan now for my rats is to take large daily doses of Creatine for one week prior to and throughout my run with the ace.
The rats protocol will be as follows:

ace 031 - 1mg injected sub q once per week for three weeks
creatine mono hydrate - 20g a day for a week and 14g a day for the duration of the cycle.

I have read enough literature on these two to figure it's worth a shot.

[cybrsage]

ACE-031 was dropped from human trials due to all test subjects (both fully healthy and the sick test subjects) eventually getting nose bleeds for no reason whatsoever. They were unable to figure out how to make them stop. YK-11 is the next promising Myostatic Inhibitor. So far, its only known side effects are a weakening of the connective tissues. I would run YK11 with MK667. MK677 acts like HGH in the body and HGH is known for strengthening the connective tissues.