Mk677- The No BS Straight Scoop ....

[StanG]

Mk677- The No BS Straight Scoop ....



I see so much misinformation on this compound I decided to do a little write up on it to put to rest some misconceptions as far as what it is (and isnt) and what it does (and doesnt do). I will also get into its applications, dosing protocols and stacking it as well.

First of all Mk677 is not a SARM, I repeat Mk677 IS NOT A SARM!! It has been incorrectly marketed as a Sarm and people now actually mistake it for one. A SARM activates the androgen receptor selectively, Mk677 has absolutely no impact on the androgen receptor whatsoever.

So if it isnt a SARM then what is it? t is an oral GHRP (Growth Hormone Releasing Peptide). In other words it is in the same category of compound as GHRP2 and GHRP6 and Ipamorellin except it is orally administered. That factor in and of itself (oral administration) is pretty exciting. One of the hassles with some of the other ghrp's is the frequency with which you have to inject them. An oral compound with the bio-availability necessary to illicit a significant gh release in this category of compound is quite an accomplishment. That being said keep in mind Mk677 is dosed in mg's, the injectable ghrp's are administered in mcg, so obviously a comparatively large amount of mk677 is taken compared to the other ghrps.

Since we have established that Mk677 is a ghrp that immediately helps us to understand better exactly what the compound will do for us. GHRP's act upon the ghrellin receptor eliciting the release of GH. This process is not, however, without a cost. The action upon the ghrellin recptors also elicits an increase in both prolactin and cortisol. There is also an increase in GHIH (growth hormone inhibiting hormone) in the bodies attempt to resume a state of homeostasis. The various ghrp's have differing effects when in comes to the increase in these undesirable hormones. For example GHRP2 causes the most significant increase in them while Ipamorelin causes the least significant increase in them. With the injectable GHRP's there is a direct correlation between the GH release and the increase in undesirable hormone (ie: GHRP= most gh& most undesirable hormones; ipamorelin least gh & least impact on undesirable hormones). This is another exciting thing about Mk677, in addition to oral administration it has a high release of gh with a comparatively low increase in undesirable hormones. Do not get me wrong, there is an increase in these hormones, however compared to the gh release, comparable to other GHRP's, the increase is a low one. In order to offset this increase in Prolactin, Cortisol, and GHIH without taking other compounds the simple protocol of 5 days on, 2 days off administration prevents the build up of these hormones to detrimental levels.

So we now know Mk677 is not a SARM, its an oral GHRP. We also know that it is comparatively speaking a very effective GHRP with a decreased impact on undesirable hormones. So where does it fit in for us and what kind of effects can we expect?

Well where it fits in is anywhere that an increase in GH would be desirable. The thing is this, the increase in GH with Mk677 on its own is high enough to elicit some physical changes and effects. Tats huge. By stacking Mk677 with a GHRH (Growth Hormone Releasing Hormone) such as CJC-1295 or Mod-GRF you can get those GH levels to a very high level. We are talking as high as a moderate dose of actual GH. THAT is huge!! We are talking the equivalent to 4-5iu's of gh daily with a stack of Mk677 (dosed at 25mg/day; 5 days on, 2 off) & CJC-1295 )injected2x/week at a dose of 750mcg/injection). This offers you an infrequent injection, relatively low cost alternative to actual GH. Also with all the bogus GH out there you are much more likely to get legit MK & CJC than legit GH ( I have a solid , reliable source that is a sponsor here- pm me if interested. Rules prevent me from posting their name). Now you could stack Mk677 with another GHRH beside CJC-1295, but the desirable thing abut that GHRH is the infrequent injection schedule which is why I prefer it. BTW I am not pulling these numbers and comparisions to actual GH out of a hat. These are based on my expereince WITH BLOOD WORK to support them.

So I said it is useful wherever GH would be useful. For Example, healing, anti aging and when combined with an anabolic stack increased muscle growth. Will it provide an increase in muscle mass on its own, yes, but no where near where you see some people reporting. There is a lot of BS hype and shilling going on since MK was at one time available as a supplement. This lead to BS and false claims as to its effects and then the"fit in crowd"posted they were getting the same results. (The fit in crowd are the ones that say **** just to fit in). The fact is on its own MK is not extremely anabolic per se, but it is extremely effective (just as effective as GH ) and when combined WITH anabolics it becomes and extremely anabolic addition. Thats the whole premise of GH use in bodybuilding guys. GH in and of itself is not extremely anabolic , especially when compared to steroids. However when added TO steroids, look out!!

Now lets talk a bit abut side effects. I see a ton of people talking about bloat with Mk677. There is a lot of confusion as to why this occurs and how to prevent it. Many people drop the dosage however by doing so you directly impact the potency and effectiveness of Mk. The optimal dose for Mkk677, without a doubt, is 25mg/day. The bloat is caused by an effect in the kidneys caused by the increase in GH on vasopressin. This can easily be offset by the addition of a simple low dose daily aspirin protocol. Thats right, one 82mg aspirin/day with impact ADH (anti dieuretic hormone or vasporessin) to the point where it eliminated the bloat associated with Mk677.

I think that abut covers it. I covered all the main points. Mk is not a SARM, it will not put 10-15bs of muscle on you, it does not drastically increase prolactin or cortisol, and it does not have to cause water retention. Mk677 is, IMO, a god send. It has allowed me too, by stacking it with CJC-1295, be on what is essentially an affordable, infrequent injection, Moderate Dose, GH protocol and I am reaping all the benefits that come with that. Increased sense of well being; improved skin, hair and nails; decreased bodyfat; an increase in muscle mass (that is drastically magnified when on an anabolic of some kind). Overall I think MK is an awesome, albeit misunderstood compound. Most of the misunderstanding has spawned from BS marketing and shilling. My goal was to set the record straight on MK and put the truth out there. What I really dont understand is the compound is awesome enough based on the truth. They never really needed to over-hype it but sadly thats how some industries work.

Anyway I hope this helps someone and feel free to ask any questions on MK you would like. I will answer to the best of my ability based on my knowledge and first hand experience.

StanG

[Demigod]

Awesome post man

[Bulking whippet]

Great post brother,i have been reading up alot on mk677,was thinking of running after pct....good tip i'll take onboard with stacking cjc-1295....How long have you ran the two for?

[Pudin Head]

Thanks StanG. That is the best bit of simple information on MK that I have read. I have read heaps of threads and listened to countless podcasts where people complain of the bloat from MK. Not once have I heard how it is caused or how to help get rid of it. I used 25mg of MK per day along with 500mg of test e per week and bloated right up. Worked much better for me when I was off cycle. I'm in the same boat as you when it comes to peps that need multiple injections per day.....I just can't be fucked.
Definitely going to get some CJC and aspirin for my next run and see what happens.
Thanks again

[syrax]

Its a great addition to a peptide cycle

[StanG]

Great post brother,i have been reading up alot on mk677,was thinking of running after pct....good tip i'll take onboard with stacking cjc-1295....How long have you ran the two for?

About 12 weeks so far and I am not stopping.

[StanG]

Thanks StanG. That is the best bit of simple information on MK that I have read. I have read heaps of threads and listened to countless podcasts where people complain of the bloat from MK. Not once have I heard how it is caused or how to help get rid of it. I used 25mg of MK per day along with 500mg of test e per week and bloated right up. Worked much better for me when I was off cycle. I'm in the same boat as you when it comes to peps that need multiple injections per day.....I just can't be fucked.
Definitely going to get some CJC and aspirin for my next run and see what happens.
Thanks again

My pleasure man. Let me know how it goes for you bro!

[dorianyates]

I am interested in trying this out

[Paradox]

A genuine thank you is due here, has me really considering running this post surgery if i end up goimg down that road.

[BigEnuff]

Great post bro, very informative. Tons of knowledge here.

[Tbrotherx]

Great post but I don't think i'd ever run this stuff.... Sides seem to outweigh the results

[StanG]

Nahh not really, especially when stacked with cjc w/dac.....

[StanG]

I actually just picked up enough mk677 and cjc w/dac to keep running the combo for at least 14 more weeks and i got it at over 50% off! Im pretty stoked as I really feel like long term with this stuff is really where it is going to shine. Much like I likened it to a moderate dose gh run, where your benefits come slowly but are well retained, permanent changes, I feel that this stack provides the same. I feel like this stack has me in such a good space. I am emotionally feeling great, I have an awesome sense of well being and also physically it feels like my conditioning slowly and steadily keeps improving. By the time I am done with this I may well end up running this combo for a year we will have too see!

[JasonG]

I've ran it all year at 25mg every night. Love the stuff. I use cjc 1295 dac at 2.5mg per week, but went as high as 5mg. Sleep has been amazing. I've had a leaner offseason than ever before. I just dropped it 8 weeks out but definitely will restart it once my show is over.

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[StanG]

I've ran it all year at 25mg every night. Love the stuff. I use cjc 1295 dac at 2.5mg per week, but went as high as 5mg. Sleep has been amazing. I've had a leaner offseason than ever before. I just dropped it 8 weeks out but definitely will restart it once my show is over.

Sent from my XT1575 using Tapatalk

Awesome. Did you drop it for your show due to bloat?

[JasonG]

Awesome. Did you drop it for your show due to bloat?
I haven't gotten a ton of bloat really but yes. I would have kept it in a little longer but didn't want to buy another bottle to do so. I'm curious if I'll see a big change as far as water weight in the coming weeks to have a more accurate view if it has in fact bloated me some. I dropped the dac as well and just going to run mod grf with ghrp2 for a month then drop that as well. I may extend that an additional 2 weeks but we'll see where hunger is at.

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[StanG]

I haven't gotten a ton of bloat really but yes. I would have kept it in a little longer but didn't want to buy another bottle to do so. I'm curious if I'll see a big change as far as water weight in the coming weeks to have a more accurate view if it has in fact bloated me some. I dropped the dac as well and just going to run mod grf with ghrp2 for a month then drop that as well. I may extend that an additional 2 weeks but we'll see where hunger is at.

Sent from my XT1575 using Tapatalk

Very cool. Thanks for sharing your pre-contest plan with peps like this. Its nice to learn what people are doing in that regard. I appreciate it man!

[JasonG]

You bet and thanks for the article!

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[Kmac]

Never heard to combine it with CJC but definitely want to try that out in the near future possibly with my next cycle with some test and var seems like it could be great for some size while getting leaner.


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[Tylersburden]

Very good read brother

[Mass3000]

My peptide site was out as I placed my last order or I would've purchased.. So I'll be looking for it soon...

[bigmills]

Mk677- The No BS Straight Scoop ....



I see so much misinformation on this compound I decided to do a little write up on it to put to rest some misconceptions as far as what it is (and isnt) and what it does (and doesnt do). I will also get into its applications, dosing protocols and stacking it as well.

First of all Mk677 is not a SARM, I repeat Mk677 IS NOT A SARM!! It has been incorrectly marketed as a Sarm and people now actually mistake it for one. A SARM activates the androgen receptor selectively, Mk677 has absolutely no impact on the androgen receptor whatsoever.

So if it isnt a SARM then what is it? t is an oral GHRP (Growth Hormone Releasing Peptide). In other words it is in the same category of compound as GHRP2 and GHRP6 and Ipamorellin except it is orally administered. That factor in and of itself (oral administration) is pretty exciting. One of the hassles with some of the other ghrp's is the frequency with which you have to inject them. An oral compound with the bio-availability necessary to illicit a significant gh release in this category of compound is quite an accomplishment. That being said keep in mind Mk677 is dosed in mg's, the injectable ghrp's are administered in mcg, so obviously a comparatively large amount of mk677 is taken compared to the other ghrps.

Since we have established that Mk677 is a ghrp that immediately helps us to understand better exactly what the compound will do for us. GHRP's act upon the ghrellin receptor eliciting the release of GH. This process is not, however, without a cost. The action upon the ghrellin recptors also elicits an increase in both prolactin and cortisol. There is also an increase in GHIH (growth hormone inhibiting hormone) in the bodies attempt to resume a state of homeostasis. The various ghrp's have differing effects when in comes to the increase in these undesirable hormones. For example GHRP2 causes the most significant increase in them while Ipamorelin causes the least significant increase in them. With the injectable GHRP's there is a direct correlation between the GH release and the increase in undesirable hormone (ie: GHRP= most gh& most undesirable hormones; ipamorelin least gh & least impact on undesirable hormones). This is another exciting thing about Mk677, in addition to oral administration it has a high release of gh with a comparatively low increase in undesirable hormones. Do not get me wrong, there is an increase in these hormones, however compared to the gh release, comparable to other GHRP's, the increase is a low one. In order to offset this increase in Prolactin, Cortisol, and GHIH without taking other compounds the simple protocol of 5 days on, 2 days off administration prevents the build up of these hormones to detrimental levels.

So we now know Mk677 is not a SARM, its an oral GHRP. We also know that it is comparatively speaking a very effective GHRP with a decreased impact on undesirable hormones. So where does it fit in for us and what kind of effects can we expect?

Well where it fits in is anywhere that an increase in GH would be desirable. The thing is this, the increase in GH with Mk677 on its own is high enough to elicit some physical changes and effects. Tats huge. By stacking Mk677 with a GHRH (Growth Hormone Releasing Hormone) such as CJC-1295 or Mod-GRF you can get those GH levels to a very high level. We are talking as high as a moderate dose of actual GH. THAT is huge!! We are talking the equivalent to 4-5iu's of gh daily with a stack of Mk677 (dosed at 25mg/day; 5 days on, 2 off) & CJC-1295 )injected2x/week at a dose of 750mcg/injection). This offers you an infrequent injection, relatively low cost alternative to actual GH. Also with all the bogus GH out there you are much more likely to get legit MK & CJC than legit GH ( I have a solid , reliable source that is a sponsor here- pm me if interested. Rules prevent me from posting their name). Now you could stack Mk677 with another GHRH beside CJC-1295, but the desirable thing abut that GHRH is the infrequent injection schedule which is why I prefer it. BTW I am not pulling these numbers and comparisions to actual GH out of a hat. These are based on my expereince WITH BLOOD WORK to support them.

So I said it is useful wherever GH would be useful. For Example, healing, anti aging and when combined with an anabolic stack increased muscle growth. Will it provide an increase in muscle mass on its own, yes, but no where near where you see some people reporting. There is a lot of BS hype and shilling going on since MK was at one time available as a supplement. This lead to BS and false claims as to its effects and then the"fit in crowd"posted they were getting the same results. (The fit in crowd are the ones that say **** just to fit in). The fact is on its own MK is not extremely anabolic per se, but it is extremely effective (just as effective as GH ) and when combined WITH anabolics it becomes and extremely anabolic addition. Thats the whole premise of GH use in bodybuilding guys. GH in and of itself is not extremely anabolic , especially when compared to steroids. However when added TO steroids, look out!!

Now lets talk a bit abut side effects. I see a ton of people talking about bloat with Mk677. There is a lot of confusion as to why this occurs and how to prevent it. Many people drop the dosage however by doing so you directly impact the potency and effectiveness of Mk. The optimal dose for Mkk677, without a doubt, is 25mg/day. The bloat is caused by an effect in the kidneys caused by the increase in GH on vasopressin. This can easily be offset by the addition of a simple low dose daily aspirin protocol. Thats right, one 82mg aspirin/day with impact ADH (anti dieuretic hormone or vasporessin) to the point where it eliminated the bloat associated with Mk677.

I think that abut covers it. I covered all the main points. Mk is not a SARM, it will not put 10-15bs of muscle on you, it does not drastically increase prolactin or cortisol, and it does not have to cause water retention. Mk677 is, IMO, a god send. It has allowed me too, by stacking it with CJC-1295, be on what is essentially an affordable, infrequent injection, Moderate Dose, GH protocol and I am reaping all the benefits that come with that. Increased sense of well being; improved skin, hair and nails; decreased bodyfat; an increase in muscle mass (that is drastically magnified when on an anabolic of some kind). Overall I think MK is an awesome, albeit misunderstood compound. Most of the misunderstanding has spawned from BS marketing and shilling. My goal was to set the record straight on MK and put the truth out there. What I really dont understand is the compound is awesome enough based on the truth. They never really needed to over-hype it but sadly thats how some industries work.

Anyway I hope this helps someone and feel free to ask any questions on MK you would like. I will answer to the best of my ability based on my knowledge and first hand experience.

StanG

My problem is trusting the good old peptide companies we use for other peptides like ghrp,mt2,or cjc..any opinion on that???

from BM

[StanG]

My problem is trusting the good old peptide companies we use for other peptides like ghrp,mt2,or cjc..any opinion on that???

from BM

All i can say is I was very fortunate. My go to company proved to be just as reliable as they always have. Getting bw at 6 and 10 weeks in, both showing that the mk was as legit as their other compounds have shown to be.

[murph]

Interesting post, I have been looking at hgh but this maybe a direction I could go. Lots more homework to but thanks for the post bro

[Paradox]

Any updates on how your cycle is currently going?

[Paradox]

Any updates on how your cycle is currently going?

[CJC4ME]

Stan,
I had purchased some and I ran it briefly, however I found out after I bought it that there were reports of possible mental health issues associated with it, like major depression. Since I had already bought it, I decided to take a chance and run it to see what happened. I got similar sides to other GHRH and GHRPs, but after about a week I found that I was getting depressed, so I stopped it. With that said, it may have been psychosomatic. Anyway, I was wondering if you found that your mood changed on it?

cjc4me

[fitraver]

@StanG loved this post. Shot you a PM on it

[Tylersburden]

Has any one had any issues with it making them ichy?

[Pinkman200]

Has any one had any issues with it making them ichy?


Just started my MK from CS 2 days ago. im at 12mg/ed right now. you gotta start low. biggest side is hunger! and a ton of gas lol. slight lethargy but not unbearable. i will be jumping up to 25mg after the first week. very excited about this compound. when legit and properly dosed, everyone has positive things to say about it. im also running TE, Proviron and EQ (No GH)....... also, very random/vivid dreams! like with old friends who i havent seen in literally 10 years. i wake up and im like where the F did that dream come from lol!

[Pinkman200]

No itching Tyler, my fault bud

[Tylersburden]

I dropped down to 12. and way less skin irritation. Vivid dreams like whoa though for sure man..... Holy fuck, every other night it seems.


Just started my MK from CS 2 days ago. im at 12mg/ed right now. you gotta start low. biggest side is hunger! and a ton of gas lol. slight lethargy but not unbearable. i will be jumping up to 25mg after the first week. very excited about this compound. when legit and properly dosed, everyone has positive things to say about it. im also running TE, Proviron and EQ (No GH)....... also, very random/vivid dreams! like with old friends who i havent seen in literally 10 years. i wake up and im like where the F did that dream come from lol!

[korsaire]

great read thanks

[Pinkman200]

Has anyone gone higher than 30mg/ed?

[fitraver]

Has anyone gone higher than 30mg/ed?

No need to. Plenty of studies showing it's just diminishing returns past 30 without added benefit.

[NightHawkDC2]

Just started my MK from CS 2 days ago. im at 12mg/ed right now. you gotta start low. biggest side is hunger! and a ton of gas lol. slight lethargy but not unbearable. i will be jumping up to 25mg after the first week. very excited about this compound. when legit and properly dosed, everyone has positive things to say about it.

Are you just running the MK, or are you running the CJC as well?

[Pinkman200]

Are you just running the MK, or are you running the CJC as well?

Just MK....Test, EQ, Proviron and 10mg Cardarine....

Yeah no reason to go past 30mg, just wanted to see if anyone pushed it further than 25mg

[CJC4ME]

I didn't see anything about depression associated with this GHRH. Admittedly I only scanned the article, so I may have missed it. I took the compound and it caused depression. Very affluent members of the GHRH & GHRP community, such as the late DATBTRUE, have expressed concerns about this terrible side effect. If you have never suffered from clinical depression, then I must say, you want no part of it. It's terrible and it takes weeks to go away, or at least that was the case with me. Others may not experience this, however if you do, it may take longer than a few weeks to go away. I just want people to know this. The feeling of not wanting to live is pretty horrific. My advice is to forgo this compound and use a long term GHRH such as CJC w/ DAC along with a non-grenlin provoking compound such as Ipamorelin or something similar. You may want to experiment with a double dose of Ipam win a nasal spray. In theory, the amino acid chain is small enough to pass through the nasal membrane. GH or GHRH are really long chains and this simple wouldn't work with an intranasal application. Hope this helps.

[NightHawkDC2]

Wondering if I'd see benefits of this while attempting a cut...or for leaning out in general? Would it be counter-productive due to the hunger? In your experience, how long does the ravenous hunger last? Reading, Seems that the hunger tends to subside.

[Pinkman200]

Wondering if I'd see benefits of this while attempting a cut...or for leaning out in general? Would it be counter-productive due to the hunger? In your experience, how long does the ravenous hunger last? Reading, Seems that the hunger tends to subside.


i'm almost 2 weeks in and the hunger has diminished a lot. first few days were bad...

[Pinkman200]

I didn't see anything about depression associated with this GHRH. Admittedly I only scanned the article, so I may have missed it. I took the compound and it caused depression. Very affluent members of the GHRH & GHRP community, such as the late DATBTRUE, have expressed concerns about this terrible side effect. If you have never suffered from clinical depression, then I must say, you want no part of it. It's terrible and it takes weeks to go away, or at least that was the case with me. Others may not experience this, however if you do, it may take longer than a few weeks to go away. I just want people to know this. The feeling of not wanting to live is pretty horrific. My advice is to forgo this compound and use a long term GHRH such as CJC w/ DAC along with a non-grenlin provoking compound such as Ipamorelin or something similar. You may want to experiment with a double dose of Ipam win a nasal spray. In theory, the amino acid chain is small enough to pass through the nasal membrane. GH or GHRH are really long chains and this simple wouldn't work with an intranasal application. Hope this helps.


how long into it did you notice the depression? i've seen a lot of feedback on lethargy but didnt know that it could cause depression

[CJC4ME]

I want to say it was about a week, however with depression sometimes come memory fog, so I can't be for sure. I should have logged, but I didn't. I tried searching for the information that DatBTrue was telling me about the link between MK and depression, but unfortunately I was not successful in finding anything.

[FutureIFBBProJARow23]

I've heard this is the best alternative to real hgh.

[cybrsage]

In all the PubMed studies I have read on MK677, none of them mentioned depression. Of course, while all of use are so much alike, we are also so very different from each other. It is possible it caused depression in you and that you are an outlier in this. Who knows.

MK677 works by telling the body it has to create a GH pulse - so it does. It tells the body to do this 12 (or more) times a day. The GH created by NK677 is the body's own natural GH. Not saying that is better than injectable GH, though. a 25mg dose of MK677 creates IGF levels in a person equivalent to 4IUs of pharma grade HGH.

[Masse]

Who has here the best quality of mk677 and sure, best prices pleas? Need EU suppliers.. Thanks

Gesendet von meinem SM-N9005 mit Tapatalk

[trenbolognaa]

I want to say it was about a week, however with depression sometimes come memory fog, so I can't be for sure. I should have logged, but I didn't. I tried searching for the information that DatBTrue was telling me about the link between MK and depression, but unfortunately I was not successful in finding anything.

I struggle with depression but MK didn't make it worse at least for me, the lethargy itself affected my mood, but don't think it made my depression worse if that makes sense. A few of my friends whom do not have depression have ran it without that side effect, but it could be how you react to it as well.

[Tsquared]

Has anyone had any experience running MK along side real gh? Say you pin 4 IUs in the AM and then take 25mgs of MK before bed to maximize my natural pulse at night? I wonder how much that would increase your igf levels compared to just the gh alone

[907rider]

Has anyone had any experience running MK along side real gh? Say you pin 4 IUs in the AM and then take 25mgs of MK before bed to maximize my natural pulse at night? I wonder how much that would increase your igf levels compared to just the gh aloneI have talked to someone who was doing just that. They were dosing 4 iu of gh daily in 2iu increments and 25mg MK once a day. When they were tested for gh it was in the 8iu/day range. They said the overall effect was quite powerful, and somewhat different than gh alone would have accounted for. Excellent synergy between them. Supposedly.

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[evawinter]

Yes 907rider and Tsquared. I have a whole page in my notes full of various post from others who report the same great results you mention with a combo of low dose GH with low dose MK677. Answer to your question can be found here:

see thread "GH mk677 combo"

GH MK677 combo - Professional Muscle (http://www.professionalmuscle.com/forums/peptides-growth-factors/139003-gh-mk677-combo.html)

Mike Arnold:

I think it's a great combo, especially when trying to build muscle tissue. People do it all the time with great results, so it speaks for itself. It saves the person money, stops IGF-1 induced negative feedback from shutting down endogenous growth hormone production, ensures that the body has elevated levels of all the different GH isoforms, and provides a constant supply of GH throughout the day (compared to exo. GH, which only keeps GH blood levels elevated for roughly 8 hours).

MK-677 also has its own unique set of benefits, such as appetite stimulation and greater increases in muscle fullness when compared to exo. GH on an iu to iu basis.

Cybrsage (post #44) said:

MK677 works by telling the body it has to create a GH pulse - so it does. It tells the body to do this 12 (or more) times a day. The GH created by NK677 is the body's own natural GH. Not saying that is better than injectable GH, though. a 25mg dose of MK677 creates IGF levels in a person equivalent to 4IUs of pharma grade HGH.
Yes, I agree with Cybrsage, as what we are finding is that some people using MK677 by itself and having bloodwork done are testing around the equivalent of 3iu of GH, and some lucky individuals are testing as high as the equivalent of 4iu of GH.

I had baseline IGF-1 bloodwork done (227), tested 4iu of pharm grade GH after 3 days (380), and am currently on a 4 week run of 20mg MK677 by itself, when I will have bloodwork done in several weeks to do a comparison as well, when I will report back with bloodwork.

After a week, I am a fan of MK-677, I weigh my own caps (as the taste is terrible) with a 1mg scale, and prefer taking it 1st thing in the morning, function fine on it, have a sense of wellbeing, muscle-fullness + pumps, increased recovery from workouts + anti-aging benefits as I am 48. It does feel like several IU of GH to me. Personally, I sleep very well at night by taking it in the morning. Yes, there is some appetite increase, but the fat percentage has actually gone down by 1% allready on the MK677 + keto diet except for 25g carbs 1 hour pre-workout (always from crunchy peanut butter, glycemic index of 14) and postworkout on workout days. I consume 180g of protein a day, with 50g of that from met-rx daily and fats are kept high. Non-workout days carbs are kept to less than 20g. The peanut butter helps to give me energy for the workout. Also on TRT of 200mg test c a week as well, with 1/8th to 1/4mg armidex twice a week with each 100mg shot. I continue to loose fat while fat free mass is up. Also happy to report that blood pressure is normal. I own two books on HGH: "Grown young with HGH" and "Growth Hormone Secretagogues in Clinical Practice", both books have a discussion about the results and benefits of MK677, and how it was discovered.
-------------------------------------------------------------------------------
Best article on MK677 I have read with charts and graphs from most of the studies:

The Beauty of Modern Science: Ibutamoren (MK-677):

The Beauty of Modern Science: Ibutamoren (MK-677) - Mind And Muscle (http://mindandmuscle.net/articles/beauty-modern-science-ibutamoren-mk-677/)
hxxp://mindandmuscle.net/articles/beauty-modern-science-ibutamoren-mk-677/

Here are the results of the research I did so far:
------------
self:
227 igf1---->380 igf1 (4iu chinese generic pharm grade) = 153 point jump

Peptides:
-----------
Alpha6164's (medical doctor's best friend):
167 igf1---->272 igf1 (100mcg grf(1-29) + 100mcg ghrp2 x 3 times a day) = 105 point increase

MK677:
---------
Fitraver:
224 igf1---->359 igf1 (12.5mg mk677) = increase of 135 points *
MrSaturatedfat:
232 igf1---->312 igf1 (25mg mk677) = increase of 80 points**
thebigone:
150 igf1---->242 igf1 (20mg mk677) = increase of 92 points***
machine5150:
141 igf1-----217 igf1 (20mg mk677) = increase of 76 points****
Sayitaintsoap:
unknown igf1---->376 igf1 (25mg mk677) = unknown increase*****

*See Fitraver post "bloods on 12.5mg mk677"
**See Mrsaturatedfat post "37 days on mk677"
***See thebigone post "Humatrope,MK677 and other GH labs for you guys"
****See machine5150 post "MK677 Before and After Blood Work w/ IGF Levels Raised 53.9%"
*****See sayitaintsoap post "THT's MK-677 review and blood work"

**Notice the similar point jumps between peptides and mk677, either one seems to reach a max of around 100 igf-1 points.

I am currently running only 20mg mk677 all by itself for 3 weeks, then will get bloodwork, and post the results. Then I will run only 4iu of GH by itself for a good 3 weeks, then post results, so that I can get a more stable long-term igf-1 reading. Would love to see the comparison.
--------------------------------------------------------------------
A few favorite quotes on Mk-677 at lower dosage:

Cybersage (from forum):

Yes, Fitraver saw an over 100 point increase while running it at 12.5mg (half dose)
Sandpig: (9/6/2017)

Drop down to 12.5 . Eventually the lethargy and other issues will slowly fade. Once they do, you can bump it up again. Took me two months at 12.5 before I could go to 25.
Elvia1023: (19,000 posts)

Everyone responds differently but 25mg is far too much for you. Others are fine at that dose but most aren't. I would recommend 10-12.5mg and with that the side effects will be minimized but the results still there. You won't be as full and pumped but you will feel multiple times better. 10-12.5mg is great for muscle fullness, pumps, recovery, size and strength. I am fine at 10mg but once I get to 15mg and over I can barely function and the fatigue is unbearable. I actually prefer MK-677 to HGH in many ways... especially for gaining size.
RamboStallone (9/6/2017: 7,000 posts):

This is why I personally recommend starting at 5mg. MK677 increases gh/igf levels for a 24hr period from a single dose, this is longer than any other peptide or GH product, and in my opinion stronger than any gh supp including exogenous GH. I've used this stuff for years now and everytime I restart it anything over 5mg puts me on my ass. It's all the sides of increased gh/igf just more pronounced with MK677 then any other gh product including the effects. I blow up on the stuff immediately. The cts is unbearable. My recommendation, lower the dose brother.

Additional information on peptides only (for comparison purposes):

Alpha6164 (medical doctor and bodybuilder, from the long 60 page thread at prof muscle, he performed nearly a dozen bloodtests and charged them to his medical practice):

I dont think peptides in usual 2-3x daily can equal 5iu of quality GH daily. Here is why. When i was on 5iu of Rips daily, my IGF was in the 600s. That is coming from a baseline of 160s. We know from three different tesamorelin studies that 2mg of tesamorelin raised IGFs 109-180 from basline. So if i started with 160 i could go to 260-340. Now that is a great number from baseline and can be almost a 200% increase and you will get fat loss benefits, anti-aging etc. But definitely not in the range of 5iu of synthetic GH.

My best friend and partner was on 100/100mcg of GRF/GHRP-2 three times a day and his IGF increased about 120 from baseline. So very in line with 2mg of tesamorelin.
Alpha6164 said

My best friend used GRF1-29/ghrp-2 100/100 three times daily and his IGF went from 167 to 272 in 8 weeks. Yes we are not getting IGFs in the 500-700s as with high dose GH but having a rise of 40% on such a small dose is pretty significant.
Alpha6164 in conclusion said:

Peptides will raise your GH as if you were on 2-3iu of synthetic GH daily. So it is great for people that wanna be on anti-aging dosage or for fast loss purposes.

Using a 100/100mcg combo 3x daily will raise your IGF similar to if you were on 2-3iu of GH daily. Most people on 4iu of GH will have IGFs in the high 300s to low 400s. But raising your IGF by 100-150 points from baseline can only help you with better recovery, healing, metabolism etc.
1st lab is baseline igf-1 [227, high] (age 48, ref is 67 to 205 ng/mL)

2nd lab is igf-1 [380, high] after being on 4iu of Chinese pharm grade for only 2 days (95 point increase per each 1iu)

3rd lab (upcoming in 3 weeks) is igf-1 after being on 20mg of mk677** (by itself) for 3 weeks

** note: taking 20mg mk677 by itself in morning with 200mcg huperzine A + NOW brand EGCg caffeine free green tea extract--400mg (contains 200mg EGCg/80% catechins, using these to help keep somatostatin down).
2375523756
Note: I have been taking the mk677 at 20mg in the morning only and sleep very well at night (normal 8 hours plus), vivid dreams are often noticed (similar to GH). I get disrupted sleep (get less sleep) when I tried taking it before bed or even a few hours before bed, Keep in mind that the body needs some time to adjust to the compound I think as well. I had problems with lethargy in the past (when I tried mk677 months ago for a few days, then gave it up) since I was taking it at night and getting less sleep which I think led to tiredness during the day at work. My body does not react well to taking anything before bed. But when I take the MK677 in the morning, I get a good sense of well-being every day (my spouse even said I had been coming home every day after work in a good mood, and that she loved the change) and no lethargy issues thus far after a week. Everyone is different and you have to find what works for you. Mike Arnold also reported he gets no lethargy on it, so I guess everyone responds differently. Water retention does not seem to be too bad from the compound while being on a low carb targeted keto diet.

[evawinter]

So I got the results back from the bloodwork after being on 25mg of mk677 only for 2 weeks, and the result was 372 ng/ml.

That's an increase of 145 points from baseline!

227 baseline igf-1----->380 igf-1 after being on 4iu of Chinese pharm grade GH for 2 days

227 baseline igf-1----->372 igf-1 after being on mk677 only for 2 weeks.

So, in conclusion, being on mk677 for 2 weeks was similar to being on 4iu of Chinese pharm grade GH, for me anyhow, as the bloodtest proves it.

This is an incredible raise in igf-1 for my age of 48 as reference is 67-205 for my age group, and the mk677 for 2 weeks brought me beyond the high range for a young adult in their early 20's.

I couldn't be happier, this helps explain the increases in strength at the gym, as well as the fast recovery from workouts.

MK677 should bring you to the high level of a young adult if you are already at the high end for an older adult.

Older folks (59-225ug/L)
young adult (116-358 ug/L)

Ref levels from the MK677 study on healthy older adults.

So I could not be happier that MK677 brought me beyond the very high level range for a young 20 year old. I could only imagine what it could do for a 20 year old.

Mk677 at 25mg a day cost me only 15 a month for the pure powder vs 170 a month for 100 iu of pharm grade Chinese GH at 4iu for 20 days, so the cost savings is quite substantial, and shows that a person could even alternate the two from month to month (say 5iu GH only one month, 25mg mk677 only the next month) should they desire to save money, or just stay on mk677 to remain at a 4iu GH level.

p.s. keep in mind I took 25mg of mk677 every morning along with huperzine A and EGCG just once a day of both. You could also use CDPcholine and vitamin B5 in place of the huperzine A, this all helps to lower somatostatin.24164

[evawinter]

So in conclusion:

4iu of GH for just 2 days --------> increased igf-1 levels 68% from baseline.

25mg of MK677 @ 2 weeks----->increased igf-1 levels 64% from baseline.

note: MK677 was taken in the morning along with 100mcg huperzine A + 200mg caffeine free EGCG to help lower somatostatin.

[evawinter]

Comments on the 2 weeks: remember that everyone reacts differently, I have been using it at 25mg every morning for 2 weeks, get no lethargy, great sense of well being, increased energy, even my spouse said my mood improved after coming home from work the past 2 weeks, as I was in a good mood compared to my normal stressed self. I actually feel younger on the stuff at age 48. I spend only 15 a month for 25mg a day, as I get the pure powder and weigh it myself into caps with a cheap quality 1mg scale. Keep in mind I did work my way up to 25mg, by starting at 15mg for day 1-3, then 20mg for 2 days, then went up to 25mg.

Perhaps the increase in igf-1 and increased amount of low level (12+ a day) GH pulses helps to explain why I feel younger on the stuff. Strength increased in the gym by 5 lbs+ on all upper body in 2 weeks for same reps, while squats and leg press went up 20 lbs (and +10lbs on hamstring curl) for same reps while on the mk677...I'm staying on this stuff forever (with breaks here and there) absolutely love it.
------------
To sum up the results of the research I did so far:
------------
self:
227 igf1---->380 igf1 (4iu chinese generic pharm grade) = 153 point jump

Peptides:
-----------
Alpha6164's (medical doctor's best friend):
167 igf1---->272 igf1 (100mcg grf(1-29) + 100mcg ghrp2 x 3 times a day) = 105 point increase

MK677:
---------
self:
227 igf1---->372 igf1 (25mg mk677) = increase of 145 points******
Fitraver:
224 igf1---->359 igf1 (12.5mg mk677) = increase of 135 points*
MrSaturatedfat:
232 igf1---->312 igf1 (25mg mk677) = increase of 80 points**
thebigone:
150 igf1---->242 igf1 (20mg mk677) = increase of 92 points***
machine5150:
141 igf1-----217 igf1 (20mg mk677) = increase of 76 points****
Sayitaintsoap:
unknown igf1---->376 igf1 (25mg mk677) = unknown increase*****

*See Fitraver post "bloods on 12.5mg mk677"
**See Mrsaturatedfat post "37 days on mk677"
***See thebigone post "Humatrope,MK677 and other GH labs for you guys"
****See machine5150 post "MK677 Before and After Blood Work w/ IGF Levels Raised 53.9%"
*****See sayitaintsoap post "THT's MK-677 review and blood work"
******self: note took in morning with 100mcg huperzine A + 200mg caffeine free EGCG to help lower somatostatin (instead of huperzine A you could also use CDPcholine + vitamin B5).
----------------------------------
1st lab is baseline igf-1 [227, high] (age 48, ref is 67 to 205 ng/mL)

2nd lab is igf-1 [380, high] after 4iu of Chinese pharm grade for 2 days (95 point increase per each 1iu)

3rd lab is igf-1 [372, high] after 25mg mk677 for 2 weeks241902419124192

[evawinter]

Concluding notes:

bottom graph: It turns out the level of 372 igf-1 the MK677 brought me too is right around the level of most 16 year old boys and girls (between 300 to 400 igf-1).

StanG (from here):

Now lets talk a bit abut side effects. I see a ton of people talking about bloat with Mk677. There is a lot of confusion as to why this occurs and how to prevent it. Many people drop the dosage however by doing so you directly impact the potency and effectiveness of Mk. The optimal dose for Mkk677, without a doubt, is 25mg/day. The bloat is caused by an effect in the kidneys caused by the increase in GH on vasopressin. This can easily be offset by the addition of a simple low dose daily aspirin protocol. Thats right, one 82mg aspirin/day with impact ADH (anti dieuretic hormone or vasporessin) to the point where it eliminated the bloat associated with Mk677.
Dropping the dose to 10 to 15mg can also reduce bloat but will still be very effective, studies with just 10mg still showed large increase in igf-1. Another way to control is to be on a targeted year round low carb, high fat/protein keto-diet (which I follow) with increased carbs around workout times/days. Don't think of the minor increased water weight as bad, it has allowed for some rather fast moderate increases in strength in the gym + the muscles feel pumped and very full, and my joints feel incredible as before the mk677 I had had some joint issues which cleared right up about 2 weeks into the mk677.

I was extra hungry for the 1st week on it, but after that the increased hunger died down/went away. In 2 year studies on mk677, it was still effective (no desensitization), and the level of igf-1 at the 1 year point was actually measured and found to have increased beyond what it was at the 3 week level.

The 1st day I took it, I felt a bit funny (even euphoric) as it raises your GH level super sky high, but then the body will sense the increased igf-1 the next day and instill a feedback mechanism to keep it within the level of a teenager after that.24202

[toretto]

I would like to ask
Has anyone had any negitive feeedback on insulin sensitivity while using mk677

I have read about this however have not spoken to anyone that has had this problem

[evawinter]

Yes toretto. MK677 similar to GH is going to lower your insulin sensitivity a bit, I would suggest taking 1 capsule of Arazo's blood sugar support (read 600 reviews at amazon) or anything similar 1/2 hour before every meal & protein shake to improve insulin sensitivity + shuttle excess glucose towards muscle and liver and not fat storage. These glucose disposal agents have been found my many reviewers to work even better than metformin without the side effects, and blood sugar was lowered from 130 and 120 down to 80 and similar readings for those with issues, helps with weight loss, etc. 1g Cinnamon supplement (not the extract) was also shown in several studies to lower blood sugar levels by 25%, just read the study at ergo-log.

[evawinter]

With the money I save not having to buy GH monthly, I have spent a small portion of the money buying top sirloin in bulk at costco (and put the rest of money in 401k) and cook on my electric grill (super easy clean up, just replace foil in round plate catch below the grill) at 450 degree F outside on porch, no mess like cooking/broil splatter in the oven. Electric grills are awesome, also throw in a foil pouch with water soaked mesquite chips with holes poked in the foil to give a smoke flavor to the steaks. Steak + eggs + salmon + metrx = great protein weekly.

I am still on the year-round targeted ketogenic diet (TKD, carbs kept to less than 25 grams daily) except on workout days when I consume 40 grams pre-workout (1 to 1.5 hour before) in the form of oatmeal (plus a few raisins) microwaved in milk. Then add a pre-cut up frozen bannana to my postworkout met-rx pure protein shake for some postworkout carbs, then of course back to keto diet for the rest of the day. Been loosing fat this way while adding muscle weekly. I also take 1 tablet of blood sugar support from arazos 20 minutes before meals, to keep insulin working effectively as mk677 and GH both will decrease your insulin sensitivity a bit.

Supplements daily:
* 50 grams met-rx pure protein plus,
* 25mg mk677 in morning + 50mcg (1/2 a huperzine tablet) + a formula which contains 200mg cdp choline + 100mg alpha gpc choline (this all helps keeps somatostatin low as GH works thru the choline system)
* 1 tablet arazo blood sugar support (glucose disposal agent) 20 minutes before meals, sometimes throw in additional chromium picolinate and vanadyl sulfate (reduces blood sugar 20%) or cinnamon supplement (reduces 25%).
* 3 grams HMB daily (buy in bulk powder form from bulksupplements, 6 months supply around 40 dollars)
* year round 200mg a week TRT cypionate + 1/4 mg arimidex with each of the twice weekly shots of 100mg.
* 5 grams creatine daily
* give blood every few months

workout schedule:
1st day: chest, triceps, shoulders [push]
2nd day: rest
3rd day: legs + abs
4rth day: rest
5th day: back, biceps, traps [pull]
Like Dan Duchaine once wrote in his book "Bodyopus" working out each bodypart just once a week is highly effective.

fun schedule for mental & spiritual health:
go to waterpark to go swimming at least once or twice a week = nature peace of mind
other days: walk dog in shaded park with river and clear streams and hundred year old trees = nature peace of mind
stay mindful spiritually

movies seen recently:
Annihilation with Natalie Portman (sci-fi)
Submergence with Alicia Vikander (actress from Tomb Raider)

** I will back at the end of July with more followup bloodwork after being on MK677 for 4 months + spouse bloodwork upcoming.

Summary: 25mg mk677 daily in am with choline enhancers increased my igf-1 from 227 to 372 total in 2 weeks, increase of 145 points, which is very similar to 4iu of Chinese pharmacy grade GH which is used to treat dwarfism in China.

I have been on 25mg daily of mk677 for 2 months now, added 60 lbs to 20 rep squat in that time, and all upper body lifts went up around 5lbs weekly. Get about an added 20 to 25% increase in strength from it just like JohnJuanb1.

The study on older healthy adults shows the igf-1 levels continue to rise up to high at the 6 month period, then level around there and stay at that high 6 month elevation even at the 1 and 2 year mark. I will be conducting igf-1 bloodwork not only at 4 months, but also at each 1 year anniversary to chart my own as well.

You can control bloat pretty well by staying on a ketogenic diet like myself if need be, I'm on this diet year-round.

[JayDog]

Great post bro, thx

[Chilidog]

I need

[Johnjuanb1]

MK-677 is my favorite bodybuilding supplement after AAS. It’s so immediate in its benefits that there’s no denying whether or not you have legit product. My strength goes up within days. My bad rotator cuffs and knees feel cushioned and safer allowing me to go heavier and attain more repetitions. The pump and nitrogen retention in the muscles is the best! Dreams are more vivid and sometimes lucid.
I like this graph that shows the GH pulses from one 25mg dose of MK-677 over a 24 hour period. As you can see there are many GH pulses from on oral dose with the greatest HGH peak approximately 14 hours and 20 minutes after administration. IGF1 levels remain elevated even after a year of daily use. I prefer dosing it a couple hours before bed. Morning dosing knocks me on my butt.

[Ranger15]

Thanks so much for this post really appreciate ready quality insight on things with real world experience on it. Was actually going to be using this in the very near future but didn't know about the other peptide will look into it also. thanks brother

[Johnjuanb1]

Thanks so much for this post really appreciate ready quality insight on things with real world experience on it. Was actually going to be using this in the very near future but didn't know about the other peptide will look into it also. thanks brother
I just take MK-677 with melatonin before bed. Melatonin is a mild somatostatin inhibitor. Huperzine A in the morning is a very good somatostatin inhibitor. So is horny goat weed.

[Cratos]

With the money I save not having to buy GH monthly, I have spent a small portion of the money buying top sirloin in bulk at costco (and put the rest of money in 401k) and cook on my electric grill (super easy clean up, just replace foil in round plate catch below the grill) at 450 degree F outside on porch, no mess like cooking/broil splatter in the oven. Electric grills are awesome, also throw in a foil pouch with water soaked mesquite chips with holes poked in the foil to give a smoke flavor to the steaks. Steak + eggs + salmon + metrx = great protein weekly.

I am still on the year-round targeted ketogenic diet (TKD, carbs kept to less than 25 grams daily) except on workout days when I consume 40 grams pre-workout (1 to 1.5 hour before) in the form of oatmeal (plus a few raisins) microwaved in milk. Then add a pre-cut up frozen bannana to my postworkout met-rx pure protein shake for some postworkout carbs, then of course back to keto diet for the rest of the day. Been loosing fat this way while adding muscle weekly. I also take 1 tablet of blood sugar support from arazos 20 minutes before meals, to keep insulin working effectively as mk677 and GH both will decrease your insulin sensitivity a bit.

Supplements daily:
* 50 grams met-rx pure protein plus,
* 25mg mk677 in morning + 50mcg (1/2 a huperzine tablet) + a formula which contains 200mg cdp choline + 100mg alpha gpc choline (this all helps keeps somatostatin low as GH works thru the choline system)
* 1 tablet arazo blood sugar support (glucose disposal agent) 20 minutes before meals, sometimes throw in additional chromium picolinate and vanadyl sulfate (reduces blood sugar 20%) or cinnamon supplement (reduces 25%).
* 3 grams HMB daily (buy in bulk powder form from bulksupplements, 6 months supply around 40 dollars)
* year round 200mg a week TRT cypionate + 1/4 mg arimidex with each of the twice weekly shots of 100mg.
* 5 grams creatine daily
* give blood every few months

workout schedule:
1st day: chest, triceps, shoulders [push]
2nd day: rest
3rd day: legs + abs
4rth day: rest
5th day: back, biceps, traps [pull]
Like Dan Duchaine once wrote in his book "Bodyopus" working out each bodypart just once a week is highly effective.

fun schedule for mental & spiritual health:
go to waterpark to go swimming at least once or twice a week = nature peace of mind
other days: walk dog in shaded park with river and clear streams and hundred year old trees = nature peace of mind
stay mindful spiritually

movies seen recently:
Annihilation with Natalie Portman (sci-fi)
Submergence with Alicia Vikander (actress from Tomb Raider)

** I will back at the end of July with more followup bloodwork after being on MK677 for 4 months + spouse bloodwork upcoming.

Summary: 25mg mk677 daily in am with choline enhancers increased my igf-1 from 227 to 372 total in 2 weeks, increase of 145 points, which is very similar to 4iu of Chinese pharmacy grade GH which is used to treat dwarfism in China.

I have been on 25mg daily of mk677 for 2 months now, added 60 lbs to 20 rep squat in that time, and all upper body lifts went up around 5lbs weekly. Get about an added 20 to 25% increase in strength from it just like JohnJuanb1.

The study on older healthy adults shows the igf-1 levels continue to rise up to high at the 6 month period, then level around there and stay at that high 6 month elevation even at the 1 and 2 year mark. I will be conducting igf-1 bloodwork not only at 4 months, but also at each 1 year anniversary to chart my own as well.

You can control bloat pretty well by staying on a ketogenic diet like myself if need be, I'm on this diet year-round.

Cant wait to see results. One question though. How come you don't use 25mg MK with 200mg Huperzine A 3x/day? Would that not significantly lower somatostatin compared to the stack you are running?

[Revelations]

Maybe on paper this could be true, but I just wrote a lil something about this. MK cannot and should not be compared to growth in any way because they are not the same and personally I get different results from the two. They need to come out with some sort of study that has two identical athletes that have the same diet and exercise routine. One should use 4-5 ius of pharm grade HGH and Ill let the other guy use as much MK and CJC or whatever other peptide he chooses. Guarantee the guy on HGH will look more transformed. I like MK, I really like it for bulking due to the appetite increase. But at the end of the day it is a secretagouge while HGH 191 is endogenous. Now I'm not saying you cant combine the two for better results or that MK is worthless by no means. I just think threads where the comparison of MK to HGH are a lil overhyped. MK is great but HGH is on a different level brothers. If it wasn't people wouldn't still be spending upwards of $300 a kit (ok yes I know it can be cheaper or more expensive just throwing out an average price for good HGH) while the top of purity MK sells for $100 a gram (I havent seen it priced more than this but maybe I'm mistaken; I get good quality MK in bulk powder for around $60 or so a gram). Everyone would be using MK if this were the case haha. The bottom line is MK-677 is a great compound, but it aint HGH so please lets try to stop even trying to remotely comparing the two. I always say "You gotta pay the costs if you wanna be the boss"
-Rev

[Revelations]

I will however say if you are looking for a lil boost MK alone is a good option, also if you have a poor appetite in the offseason it is a life saver. Just don't think if you are currently using 4-5 ius of HGH that you can switch to MK. I believe by no means will you get the same benefits.
-Rev

[Jclench]

Thanks good info.

[intro74]

Thank you, very interesting thread.

[leftkz]

so is anyone running both hgh and mk677 together?

[NewSchool82]

I like how OP started this thread and hyped the shit out of MK and then people started asking follow up questions and he bounced. Guess he did his job selling the product.

[5millionbucks]

THinking about running mk677 but the water retention and hunger/lethargy makes me stay away from it. Anyone ever had success running mk677 without these problems?

[PBandJ]

This is my first post here. Just wanted to share my experience with MK and possibly a way to make it a lot more effective. I ran it for a year straight, ending in Sept of this year. I dosed it at 20mg/ed for the first six month and took on about 8 lbs of water the first couple weeks but that eventually went away. I felt it helped a bit with recovery and retaining mass while doing EOD water fasting. Never lost any size and strength was still really good.

For the second half of the year I dissolved the MK in 99.9% pure DMSO and administered it sublingually at 10mg/ED. This is where it made a huge difference for me. Body fat steadily decreased and I got to the leanest I've probably ever been. But what made me really think this ROA was much more effective though, was that my arms started going completely numb during the night...I'm not talking about the occasional arm asleep kind of thing. I'm talking completely numb from the shoulder down every night...so numb that it was really painful when the blood started returning to the limb. This only started happening when I started the sublingual/DMSO ROA.

I know a lot of people don't like DMSO, but I thought some of you might like to give it a whirl and save a little money. I've read in some medical papers that MK's bioavailability is only around 30%. Can anyone confirm this? If so, the DMSO might be able to drastically increase the bioavailability. Anyway...if you can stand DMSO under your tongue for a few minutes it might help.

[5millionbucks]

This is my first post here. Just wanted to share my experience with MK and possibly a way to make it a lot more effective. I ran it for a year straight, ending in Sept of this year. I dosed it at 20mg/ed for the first six month and took on about 8 lbs of water the first couple weeks but that eventually went away. I felt it helped a bit with recovery and retaining mass while doing EOD water fasting. Never lost any size and strength was still really good.

For the second half of the year I dissolved the MK in 99.9% pure DMSO and administered it sublingually at 10mg/ED. This is where it made a huge difference for me. Body fat steadily decreased and I got to the leanest I've probably ever been. But what made me really think this ROA was much more effective though, was that my arms started going completely numb during the night...I'm not talking about the occasional arm asleep kind of thing. I'm talking completely numb from the shoulder down every night...so numb that it was really painful when the blood started returning to the limb. This only started happening when I started the sublingual/DMSO ROA.

I know a lot of people don't like DMSO, but I thought some of you might like to give it a whirl and save a little money. I've read in some medical papers that MK's bioavailability is only around 30%. Can anyone confirm this? If so, the DMSO might be able to drastically increase the bioavailability. Anyway...if you can stand DMSO under your tongue for a few minutes it might help.

If the absorption is so low in liquid and caps; why is the side effects so strong on 10-25mg like lethargy, appetite, and water retention? While doing this with DSMO did you get all the side effects too? Its possible since you've been on it for 6 months your body had adjusted.

[PBandJ]

I totally agree that since I'd been on it long term it was starting to work better (even if I didn't switch to DMSO). The numbness started nearly overnight though after trying the sublingual ROA in DMSO. I never really had a lot of sides on it other than the water retention in the beginning. I'm also not very sensitive to ghrelin due to water fasting on anabolics for cutting purposes. I can't confirm the 30% bioavailability either. I went digging through studies again and can't find any numbers. I hear a lot of people saying the bioavailability is high but I can't find any evidence of that. This is all in theory anyway. I don't have any bloods to confirm that it is a more effective ROA. Sure seemed like it though

[Ryujiin]

Just drop in to state that I am a week into the original protocol of 25mg E5D, with 2D's off. Doing recomp.

For me, lethargy and hunger have not been an issue (running alot of products in the recomp that include solid doses of caffeine, EGCG, VAR, and DIM.) I will say that the bloat has been pretty rough, and I just started daily LD aspirin, so will see if that helps.

On the positive side, my muscles are really full compared to last week and a swear Im leaner. Sleep has also improved (a huge item for me given I normally sleep like ass)

Will drop back in after a few more weeks, unless it also makes me look younger and then Ill be too busy...watching porn, as Im still ugly as fuk.

[BIGBLOCK777]

Thank you for the info bro. I commend you on the time and effort. Question: if you may, can you inbox me a great supplier? I want to get my hands on this. Much appreciated.

[BIGBLOCK777]

Wow, after seeing this post. I am thoroughly impressed. I just found out about this compound 2 days ago. I want to thank everyone for the honesty and info here. You guys rock !

[b40361]

can you inbox me a great supplier? I want to get my hands on this....thanks brothers

[notorius]

Same here, but I am seeking a source which has the injectable version, I hear good outcome from its use. PM me a source if you know any.


can you inbox me a great supplier? I want to get my hands on this....thanks brothers

[Gainzz]

I took this back when Sarms were everywhere and this chemical was grouped in with them. I liked the quality sleep, appetite, and well being I got from it.

[Mikeyz206]

I like this post and thank you for it. Thanks, StanG

[Goku55555]

Love mk677! I have made pretty good gains from it and would love to try it with CJC 1295

[subunit]

Looks like we are all asking for and looking for the golden question...where are the “supplies” sponsors on here? Does anybody carry the legit stuff?

[Drillit]

Looks like we are all asking for and looking for the golden question...where are the “supplies� sponsors on here? Does anybody carry the legit stuff?

I have a handful of solid sources for it. They are out there. IA here carries good MK. 10mg caps.

[Goku55555]

Awesome post! Just to clarify do you guys use No DAC or just DAC CJC 1295?

[danabol]

I sometimes run 50mg gone higher but mostly in only 50-30mg. I tried with dac had blood work had tech issies so going to fo it again on mk676 and cjc dac with
Mk666 alone my off is 50% above range.

My protocol is 10-20mg post work 20-30mg before bed with 10mg of melatonin, propranolol 60mg, niacin 400mg plus. Been using mk666 straight for 7-10 years. I get blood work all but stopped mk after 14 months ED cause my bloods showed high tsh. My TSH
Adding it back all back in agyerb2-3 ~weeks brrsk then I'll get igf-1 bloodwork.

Last blood work affer dropping shows tsh levels really high but when on mk666 had TSH 1.5. Was 3m5 3 months ago. Its been going down from top of range lower each year last one was in the number halfed in a few months Any had one else had issues with hgh or mk-677. Or ideas what I should do thanks

Dam mk677 cost heaps and ks harder to find since I started. Cant find yk-11 locally atm. Had god results with 1-2g injectables mk677 and yk-11
Best taking post work and before bed.

Long term bloat goes down hold less water. Effects seem to always be around top of limit or just above even after years. Get get 50% above rangebloodwork on just mk677, niacin, choline, propranolol and melatonin.
Tried clonidine and arginine and amgatative sulfate also clonidine seem to hell. Also used gaba drugs like baclofen and nitrazepam to increase it helps but most these ones dont work with chronic usagem

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[netoob]

Great read! Thanks for the knowledge! Now off to find a legit source.

[cyborg73]

Great post brother

[Jaggs91]

Great read

[Noob]

So what are the benifets didn’t see anything about it

[iconpharma]

i heard some ok things about it. i prefer the 'real stuff' in general, old skool proven what works

[cmeliftheavy]

Agree with everyone this is a great post, allot of data e planing what. Have been sharing with others. For God sake people stop labeling it as a peptide, you explained it perfectly . Thanxs for the post

[quadzilla]

Great post!

[Fedexgunot]

Hey guys getting some mk and wondering what to do with it on my current blast ive been doing ***** grade gh so far, would it be too much to add it in??

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[quadzilla]

Know much about yk11?

[mightymouse84]

Hey guys getting some mk and wondering what to do with it on my current blast ive been doing ***** grade gh so far, would it be too much to add it in??

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Add it in there, just gonna help you maintain that natural HGH pulse throughout the day. Running 4ius/day alongside 20-25mg mk677 before bed.

[Plate Smacker]

Am I the only one that even when taking only 7mg, can feel the effects well, hands feel difficult to close, get tingly..... and super bloated, gassy, and poop far more than usual?

[Undefineduser7]

I’m going to have to grab myself some MK sure, been contemplating but seems as if it’s a good option!!

[Xxplosive]

First off, very good, informative post...

Second, this is experience from someone who had FAILED with Mk677 numerous times and given up due to bloat, fat gain, lethargy and kept swearing I would never touch it again.

Would like to address:

1) "Bloat" - This is, as mentioned, in large part due to PROLACTIN, which raises from elevated gh levels and is the same reason why deca/npp bloats folks.

Depending on how sensitive you are to prolactin, Vitamin B6 will do the trick and keep you dry from 300mg-1000mg a day. It's dirt cheap.

Another thing about PROLACTIN that people fail to mention, is that it slows down the metabolism of fats/protein, so you are not just getting water bloat... You're actually gonna get fat from the extra calories you consume from your elevated prolactin levels!

2) Blood Sugar - GH jacks your blood sugar up, and after a few weeks of jacked up insulin sensitivity and overeating... Again, you're getting fat. It's not bloat. Take some Berberine if trying to shed far on mk (shuts off mTor), or double up in your ALA or R-ALA doses with meals if trying to pack on muscle.

[juicemonkey]

Good read

[bigdaddy6900]

First off, very good, informative post...

Second, this is experience from someone who had FAILED with Mk677 numerous times and given up due to bloat, fat gain, lethargy and kept swearing I would never touch it again.

Would like to address:

1) "Bloat" - This is, as mentioned, in large part due to PROLACTIN, which raises from elevated gh levels and is the same reason why deca/npp bloats folks.

Depending on how sensitive you are to prolactin, Vitamin B6 will do the trick and keep you dry from 300mg-1000mg a day. It's dirt cheap.

Another thing about PROLACTIN that people fail to mention, is that it slows down the metabolism of fats/protein, so you are not just getting water bloat... You're actually gonna get fat from the extra calories you consume from your elevated prolactin levels!

2) Blood Sugar - GH jacks your blood sugar up, and after a few weeks of jacked up insulin sensitivity and overeating... Again, you're getting fat. It's not bloat. Take some Berberine if trying to shed far on mk (shuts off mTor), or double up in your ALA or R-ALA doses with meals if trying to pack on muscle.

So if on slin ould mk 677 be a bad idea due to extra carbs already being eaten


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[kydiesel75]

great info, ive been running this for 2 months now and i can definitely tell a difference

[Mr.Smith45]

Am I the only one that even when taking only 7mg, can feel the effects well, hands feel difficult to close, get tingly..... and super bloated, gassy, and poop far more than usual?

No, you're not the only one. I had to stop it after about 3 weeks, crazy water retention and such a pump in my forearms I couldn't hang on to a bar.

[evawinter]

One of my favorite all time threads.

I've been on 25mg mk677 taken in the morning with coffee since September, that makes 5 months, will continue to take until the end of Feb (6 months)....absolutely love it, have broken all my previous strength records, in the best shape of my life. To me it's a miracle cheap compound for utilizing your body's own built up natural growth hormone that is not normally used as somatostatin puts the breaks on it as you get older. Feel like and have the endurance of a 20 year old, with wonderful nootropic brain effects, quality sleep daily, and the cheap price can't be beat.


When I come off In feb, then I will use peptides using dosage instructions on 1st few pages of this thread, will use for 6 months, then go back on mk677 again so that the mk677 remains effective. The peptides never use effectiveness, but they are quite a bit more expensive. So this back and forth I've been doing for years, same results as 4 iu of HGH, but only a tiny fraction of the cost. Yes, there is a published study showing if you take mk677 powder in the morning, there is 25 to 30% higher HGH released all day long, don't know why but that's what the study found. Zero lethargy from the mk677 only good benefits.


p.s. I'm on a keto diet year round, so there is next to zero water retention from the mk677 in my face, my face looks completely normal and does not blow up from it. I get great pumps from it in the gym, just incredible, and consistent strength gains week to week way beyond what I could do without it. Love, love it. I do also take cheap enhanced brand arachiodonic acid x 4 caps each time I work out, and this also helps with great pumps and adding strength. The pumps are insane.


my mk677 thread: 25mg MK677 bloodwork FAQ = 4iu pharm grade HGH (used 25mg mk677 for 6 months out of the year for 5 years straight with 7 bloodworks) (https://brotherhoodofpain.com/hgh-igf-slin-mgf-and-all-peptides/82234-25mg-mk677-bloodwork-4iu-pharm-grade-hgh-25mg-mk677-6-months-5-straight-7-bloodworks-2.html)

[Chilidog]

well hell i dont want to be depressed. good infor

[unclem]

i had surgery on my pituitary due to tumor stanG can i take mk677 and cjc1295 since i have to take something for cortisol its called hydrocortisone tablets for rest of my life. you said that cortisol gets raised by these compound peptides and i still have a piece of pituitary left though so hgh is getting in my blood from pituitary. what do u think stan G?