AllAboutPeptides
12-19-2012, 01:00 AM
CJC with DAC
http://juicedmuscle.com/jmblog/sites/default/files/images/sequence.jpg
Written by Russianstar, This information is copyrited.
Firstly lets explain what the peptide CJC-1295 DAC is.
Molecular Formula: C152H252N44O42
Molecular Weight: 3368.7
Sequence of CJC1295 (modified) without DAC:
H-Tyr-(D)Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-
Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
CJC-1295 is a GHRH (the 44-amino acid long version) with 15 aminos removed, thus a total of 29 amino acids, and bound to DAC it is also called Drug Affinity Complex, and CJC-1295 is often referred to as GHRH with Drug Affinity Complex, this essentialy lengthens its life span.
This is how its life is lengthened.
The modification of growth hormone releasing factor with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 2 create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By utilising the Drug Affinity Complex technology to GRF, the peptide selectively binds to circulating albumin after subcutaneous administration, thus prolonging its half-life.
As you may notice its basicly semorelin with 15 aminos removed. This was because semorelin degrades too rapidly to really make it a viable cost efficient option.
So they bonded it with an attached 3-maleimidopropionic acid (MPA) unit, which results in binding to albumin after exogenous injection into blood plasma, and creates a far longer half life, this is the DAC, or druf affinity complex i made referance to earlier.
Now it works by this action as its a GHRH, or growth hormone releasing hormone, In the healthy human body, large amounts of growth hormone are stored in the pituitary. The cells within the pituitary release growth hormone in response to signalling by GHRH (Growth Hormone Releasing Hormone) Then the peptide Ghrelin is (of which GHRPs ? Growth Hormone Releasing Peptides ? are mimetics), inhibited from releasing these stores by Somatostatin. GHRH and Ghrelin act on different populations of somatotropes (GH releasing cells). GHRP and Ghrelin increase the number of somatotropes releasing GH but not the amount released by each cell.
GHRH affects both the number of secreting cells and ? moreso ? the amount they are actualy able to secrete. GHRH and Ghrelin are released in specific patterns that vary depending on what the person involved is doing, or has been doing post-exercise. Now CJC-1295 DAC has been proven to stimulate slow wave sleep, and this is the period of sleep when most of your bodys repairing work takes place on muscles and tissues etc.
Now most people can and will make GH in their own pituitary gland, but not everyone can release it in the amounts needed, so from a medicinal point CJC-1295 DAC can be very beneficial.
Now for its benefits to reach full potential......
To read the remainder of the article and many more on research peptides and liquids click Here (http://allaboutpeptides.com/cjc-with-dac/)
http://juicedmuscle.com/jmblog/sites/default/files/images/sequence.jpg
Written by Russianstar, This information is copyrited.
Firstly lets explain what the peptide CJC-1295 DAC is.
Molecular Formula: C152H252N44O42
Molecular Weight: 3368.7
Sequence of CJC1295 (modified) without DAC:
H-Tyr-(D)Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-
Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
CJC-1295 is a GHRH (the 44-amino acid long version) with 15 aminos removed, thus a total of 29 amino acids, and bound to DAC it is also called Drug Affinity Complex, and CJC-1295 is often referred to as GHRH with Drug Affinity Complex, this essentialy lengthens its life span.
This is how its life is lengthened.
The modification of growth hormone releasing factor with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 2 create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By utilising the Drug Affinity Complex technology to GRF, the peptide selectively binds to circulating albumin after subcutaneous administration, thus prolonging its half-life.
As you may notice its basicly semorelin with 15 aminos removed. This was because semorelin degrades too rapidly to really make it a viable cost efficient option.
So they bonded it with an attached 3-maleimidopropionic acid (MPA) unit, which results in binding to albumin after exogenous injection into blood plasma, and creates a far longer half life, this is the DAC, or druf affinity complex i made referance to earlier.
Now it works by this action as its a GHRH, or growth hormone releasing hormone, In the healthy human body, large amounts of growth hormone are stored in the pituitary. The cells within the pituitary release growth hormone in response to signalling by GHRH (Growth Hormone Releasing Hormone) Then the peptide Ghrelin is (of which GHRPs ? Growth Hormone Releasing Peptides ? are mimetics), inhibited from releasing these stores by Somatostatin. GHRH and Ghrelin act on different populations of somatotropes (GH releasing cells). GHRP and Ghrelin increase the number of somatotropes releasing GH but not the amount released by each cell.
GHRH affects both the number of secreting cells and ? moreso ? the amount they are actualy able to secrete. GHRH and Ghrelin are released in specific patterns that vary depending on what the person involved is doing, or has been doing post-exercise. Now CJC-1295 DAC has been proven to stimulate slow wave sleep, and this is the period of sleep when most of your bodys repairing work takes place on muscles and tissues etc.
Now most people can and will make GH in their own pituitary gland, but not everyone can release it in the amounts needed, so from a medicinal point CJC-1295 DAC can be very beneficial.
Now for its benefits to reach full potential......
To read the remainder of the article and many more on research peptides and liquids click Here (http://allaboutpeptides.com/cjc-with-dac/)