Myostatin gene knockout?

[Thompsoncustom]

Anyone ever looked into myostatin gene knockout? Sounds pretty interesting, it's where the use crispr and modify your genes to remove the myostatin producing gene.

Seems like it works great in mice and chickens so far but I have yet to find any myostatin gene knockout study's on human. I know I would pay good money to be able to permently remove myostatin.

So what do you guys think is this something we will have available in the future?

[Big Joe]

Anyone ever looked into myostatin gene knockout? Sounds pretty interesting, it's where the use crispr and modify your genes to remove the myostatin producing gene.

Seems like it works great in mice and chickens so far but I have yet to find any myostatin gene knockout study's on human. I know I would pay good money to be able to permently remove myostatin.

So what do you guys think is this something we will have available in the future?I'm still not sure all I can say is i tried 14 days of follinstatin and put on 8lbs of wieght mostly muscle but the only thing didn't like was I felt like shit after injection and another side effect if ur dosage isn't on target u get flu like symptoms like a mofo thought I was dying..

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[JohnMcc]

Interesting, I hope Max pops in here because I think he has some knowledge that would contribute to this thread.

[Thompsoncustom]

Here are some studies where they used crispr to delete myostatin gene expression in muscle tissue.

The first one here shows 2 lambs one normal and the other one with the myostatin gene deletion 30 days after birth.

Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136690)

https://journals.plos.org/plosone/article/figure/image?size=large&id=info:doi/10.1371/journal.pone.0136690.g006

second is pretty much the same thing in rabbits.

Figure 2 | Scientific Reports (https://www.nature.com/articles/srep25029/figures/2)

https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fsrep25029/MediaObjects/41598_2016_Article_BFsrep25029_Fig2_HTML.jpg?as=we bp

this has also been done is chickens and mice so I image it's only a matter of time till there are some form of human trails, I'll gladly sign up any time.

[Jayjaytocool]

I watched a documentary about crisper and underground gene hacking basically. They had a guy in there that was doing exactly that. Only things is there was no follow up. It seemed like something u can do at home with enough info or maybe some smart college kids. If u find anything out let us know for sure.

[Jayjaytocool]

I found the link to the guy. He sells a kit. I know nothing else
CRISPR muscle boosting gene therapy at few thousand dollars per year will go mainstream | NextBigFuture.com (https://www.nextbigfuture.com/2017/11/diy-biohacking-with-crispr-gene-therapy-for-muscle-boosting-myostatin-inhibitor.html)

[Mr.Beefy]

I found the link to the guy. He sells a kit. I know nothing else
CRISPR muscle boosting gene therapy at few thousand dollars per year will go mainstream | NextBigFuture.com (https://www.nextbigfuture.com/2017/11/diy-biohacking-with-crispr-gene-therapy-for-muscle-boosting-myostatin-inhibitor.html)

Don't believe this hype... supposedly he did this, but nothin has been shown.

[Pedro]

Interesting topic; As far as i know:
1) Gene knock-out on that studys/examples (sheep and rabbits) are made when they are in embryo state, thats probably the main reason why the guy is talked about is not getting similar results:

I found the link to the guy. He sells a kit. I know nothing else
CRISPR muscle boosting gene therapy at few thousand dollars per year will go mainstream | NextBigFuture.com (https://www.nextbigfuture.com/2017/11/diy-biohacking-with-crispr-gene-therapy-for-muscle-boosting-myostatin-inhibitor.html)

2) Study says: "Myostatin knockout induces apoptosis in human cervical cancer cells" as you can see in study link: Myostatin knockout induces apoptosis in human cervical cancer cells via elevated reactive oxygen species generation - PubMed (nih.gov) (https://pubmed.ncbi.nlm.nih.gov/30241032/) ,so it may not be that good alternative for now