My YK-11 Experiment

[IRISHOAK]

Details to be posted soon. I have a theory.
Am I right? Time will tell!
70684

[IRISHOAK]

Ok before we begin I gotta hit you guys with some reading assignments, so we are all on the same page...

Key Point #1:
YK-11 does NOT inhibit myostatin, it elevates Follistatin levels.

(The following abstract from PubMed explains the relationship between the two.)

Abstract

Follistatin is known to antagonise the function of several members of the TGF-beta family of secreted signalling factors, including Myostatin, the most powerful inhibitor of muscle growth characterised to date. In this study, we compare the expression of Myostatin and Follistatin during chick development and show that they are expressed in the vicinity or in overlapping domains to suggest possible interaction during muscle development. We performed yeast and mammalian two-hybrid studies and show that Myostatin and Follistatin interact directly. We further show that single modules of the Follistatin protein cannot associate with Myostatin suggesting that the entire protein is required for the interaction. We analysed the interaction kinetics of the two proteins and found that Follistatin binds Myostatin with a high affinity of 5.84 x 10(-10) M. We next tested whether Follistatin suppresses Myostatin activity during muscle development. We confirmed our previous observation that treatment of chick limb buds with Myostatin results in a severe decrease in the expression of two key myogenic regulatory genes Pax-3 and MyoD. However, in the presence of Follistatin, the Myostatin-mediated inhibition of Pax-3 and MyoD expression is blocked. We additionally show that Myostatin inhibits terminal differentiation of muscle cells in high-density cell cultures of limb mesenchyme (micromass) and that Follistatin rescues muscle differentiation in a concentration-dependent manner. In summary, our data suggest that Follistatin antagonises Myostatin by direct protein interaction, which prevents Myostatin from executing its inhibitory effect on muscle development.

Source: Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis - PubMed (nih.gov) (https://pubmed.ncbi.nlm.nih.gov/15136138/)

[Mr.Beefy]

So it's going to be tested out. Nice!! I definitely wanna know more about it. I will keep an eye on this thread. Please update us on this. Thanks Oak. :)

[IRISHOAK]

So it's going to be tested out. Nice!! I definitely wanna know more about it. I will keep an eye on this thread. Please update us on this. Thanks Oak. :)

Definitely will. Im gonna lay out all the science, then my theory, then run my protocol and log it. You will get all the info

[Mr.Beefy]

Definitely will. Im gonna lay out all the science, then my theory, then run my protocol and log it. You will get all the info

Awesome! I'm so stoked for this. :)

[maxmuscleone]

Definitely will. Im gonna lay out all the science, then my theory, then run my protocol and log it. You will get all the info

Will definitely check it out as it has been one time I’ve tried a few times for 2-4 weeks orally by itself. It is not weak ! Cannot wait to see you plan (or even future experiment) [emoji1690][emoji123]

Max

[IRISHOAK]

Starting the YK-11 tonight. I stopped everything except test so we can give a proper run.
70719

[IRISHOAK]

Ok, so for reasons Ill go into when I have a little more time to post... I think YK11 can be a powerful tool, I also think that based on all the anecdotal evidence & what little science there is on it, that people have been making 2 mistakes:
1. Dosing too high
2. Dosing too often

Took my first dose of 5mg. (This is just to start small and make sure I dont have some weird reaction or anything, "Always "taste" it before you actually TRY it, write that down!" Lol! It applies to everything!)

More updates & details soon...

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[maxmuscleone]

Nice ! Look forward to a more in depth read about your experience once your a few weeks in. It’s no joke - YK11

Max

[IRISHOAK]

I'll tell you this much, I took 5mg yesterday and I FELT growth this morning. You guys know that feeling when you are in the sweet spot of a cycle and really gaining? You wake up and stand up out of bed and you kinda feel pumped & heavier in places, esp in the places you just hit in the gym? Had that feeling all up in my lats, rear delts & arms today upon waking!

[Mr.Beefy]

that's a great feeling. So far so good on this info :) thanks again for logging this.

[IRISHOAK]

Day 3 at 5mg of XT Labs YK-11. Im feeling fuller through out the day and doing anything physical gets me a pump.
Sex... Muscle pump
Swimming... Muscle pump
Ive also noticed a steady, healthy appetite increase. Im eating more, and more often. All good things!

[Mr.Beefy]

Anything awesome to report?

[IRISHOAK]

Anything awesome to report?

Yeah, my bad... This kinda migrated into my summer log. Check out my Summer XT Log in Pomps sub.

[IRISHOAK]

YK-11 update, I can definitely say that taking at night before bed seems to give the best result. When I take it at night I feel the growth upon waking, taking it during the day may have an effect but not noticeable by feel. Makes sense bc thats when the body repairs & grows.
So I have the timing figured out.

Next I'm going to bump the dose to 10mg and see how that goes!

[bulldogger]

So it does not keep you up as some things can it sounds like? Been wondering about this one. I have done lgd and cardarine but nothing else.

[IRISHOAK]

So it does not keep you up as some things can it sounds like? Been wondering about this one. I have done lgd and cardarine but nothing else.

Nope, I sleep like a baby... No weird dreams no CNS stimulation, no other sides either so far!
Bumping to 10mg today!

Check out my main log "I.O.'s Summer Log" in the Pompsplace Sunforum for more details.

[IRISHOAK]

UPDATE: Last night I took 10mgs about an hour before bed and I had some CNS stimulation, similar to tren sleeping (which is rough) I had anxious dreams, not nightmares or anything, just anxious & kinda restless. I woke feeling pumped AF! but I also felt anxiety upon waking. 10mgs is too much before bed. (For me).

I didnt take any today. Tonight Im gonna take 5mgs before bed, then do 5 am & 5 pm and see how that plays out.

[IRISHOAK]

P.S. I had libido like a tren/mast combo before I fell asleep! Like viagra without the side effects! Everything felt amazing, better than usual sensation and really good orgasm.

[JohnMcc]

Maybe combining yk11 before bedtime with 5-10g creatine and and equal amount of bcaas to get myostatin inhibition and follistatin upregulation at the same time. More bang for buck effect wise if you will. You could throw in some epicaticin(probably mispelled) for further myostatin inhibitions for max hyperplasia and hypertrophy while sleeping.

[IRISHOAK]

Maybe combining yk11 before bedtime with 5-10g creatine and and equal amount of bcaas to get myostatin inhibition and follistatin upregulation at the same time. More bang for buck effect wise if you will. You could throw in some epicaticin(probably mispelled) for further myostatin inhibitions for max hyperplasia and hypertrophy while sleeping.

Good suggestions. I want to evaluate it solely on its own for now. Once I have a good understanding of it solo, Ill actually use it in a cycle and add other components.

[IRISHOAK]

Ok, I've played with this in a bunch of different ways and reached some conclusions:
1. It definitely works!!!
2. Most noticeable effects come from dosing 4 hours prior to bed on workout days.
3. 5mgs before bed feels good, wake up feeling light pump and growth.
4. 10mgs before bed stimulates CNS similar to tren and disrupts normal sleeping patterns. Pump and growth feeling are actually less noticeable (prob due to lack of deep sleep).
5. 5 mgs am ends up creating a viagra-type light muscle pump and crazy sex drive by bedtime.
6. 15mgs split 5,5,5 (am/lunch/dinner) produces the quickest weight gain. I did this for only 3 days and my weight (upon waking and empty everything) increased 4lbs net* *not saying 100% of that was muscle but I have a crazy high metabolism and I never put on over-all weight that fast.
7. No real negatives to report.
8. Appetite increased - in my case, I was craving oatmeal, pasta & protien sources - no cravings for sweets and my normal appetites for fats like: cheese, milk & ice cream decreased.

Im going to start a pure bulk phase in a week or 2 and I will be including YK-11! Now that I have a feel for it, I am confident doing an actual cycle with it.

Stay-tuned for: I.O.'s Pure-Bulk Log!

[Mr.Beefy]

Thank you for this info. Been keep up on this, Sounds like a good regiment for the morning and night. I'm just gonna have to pull the trigger and get myself some.

[IRISHOAK]

Thank you for this info. Been keep up on this, Sounds like a good regiment for the morning and night. I'm just gonna have to pull the trigger and get myself some.

Totally worth it! The bottle has 100 5mg tabs and its not pricey at all. XT is big and you get more than your $'s worth with any of their stuff. Im really glad I decided to look into YK-11!

[IRISHOAK]

Sorry it took so long! Lol!

[Mr.Beefy]

Totally worth it! The bottle has 100 5mg tabs and its not pricey at all. XT is big and you get more than your $'s worth with any of their stuff. Im really glad I decided to look into YK-11!

I've tried the XT Cardarine. Definitely see results, energy, endurance/stamina. So I'll definitely be getting a bottle of the YK-11..soon.

[Mr.Beefy]

Sorry it took so long! Lol!

No worries. Thank you for still posting up I.O.

[bulldogger]

You mentioned a couple dosing protocols. Which are you doing and is it every day or just workout days?

[IRISHOAK]

You mentioned a couple dosing protocols. Which are you doing and is it every day or just workout days?

I did multiple 3-4 day experiments with the doses & timing listed above. I haven't planned the cycle yet but I'll post all the details when I start the new log.

[bulldogger]

Can any of the chemistry guys tell me if yk11 will increase total T or free t on a bloodwork test? I am on trt and hoping ot find something i can take that wont increase those numbers.

I want to be clear say my normal t on trt would be 900. I want to take something that regardless of how it makes me grow will not increase that number. COuple people said look at orals ( which will but very short half life) and sarms as a way to get around the test

[Mr.Beefy]

Boron sup will increase free T without
Increasing total T.

[bulldogger]

Boron sup will increase free T without
Increasing total T.

Boron is about as much use as nuts on a steer isn't it? :)

[IRISHOAK]

Can any of the chemistry guys tell me if yk11 will increase total T or free t on a bloodwork test? I am on trt and hoping ot find something i can take that wont increase those numbers.

I want to be clear say my normal t on trt would be 900. I want to take something that regardless of how it makes me grow will not increase that number. COuple people said look at orals ( which will but very short half life) and sarms as a way to get around the test

It simply increases follistatin, which inhibits myostatin.

[bulldogger]

Got yous o will not affect numbers they are looking at?

I take it deca or eq would show my total test as higher right?

Pomp has rad and lgd know aobut them?

[Thompsoncustom]

good to see you run this Irish I've looked into the research on yk11 and it looks promising but nothing beats real world results.

Definitely have to add this to a bulk cycle sometime but I'll probably make it injectable.

[IRISHOAK]

good to see you run this Irish I've looked into the research on yk11 and it looks promising but nothing beats real world results.

Definitely have to add this to a bulk cycle sometime but I'll probably make it injectable.

So good to see you back!

[Thompsoncustom]

So good to see you back!

just been busy with life you know how it goes. starting to get things freed up a little tho so hopefully I'll get some more time on here.

[MarvelNerd]

Would this be better introduced at the half way point of a cycle when the body really elevates myostatin? Like 6 weeks in?


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[IRISHOAK]

Would this be better introduced at the half way point of a cycle when the body really elevates myostatin? Like 6 weeks in?


Sent from my iPhone using Tapatalk

Im about to run it for a full cycle, that is a great question. YK-11 doesn't have much published cycle research ... Kind of on unknown ground with it. My cycle start has been delayed by some things I had to prioritize. Trying to start in the next week or 2. It will be in the "Pure Bulk" log I introduced recently