Thread: NSAID's can inhibit muscle growth

Anti-inflammatory drugs can inhibit muscle growthDate:The long-term use of over-the-counter (OTC) anti-inflammatory drugs can inhibit muscle growth in young, healthy individuals engaging in weight training, according to a new study.

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The long-term use of over-the-counter (OTC) anti-inflammatory drugs can inhibit muscle growth in young, healthy individuals engaging in weight training, according to a new study from Karolinska Institutet, reporting on the effects of ibuprofen on the skeletal muscles and published in*Acta Physiologica

Most mild analgesic and antipyretic OTC drugs, apart from paracetamol, are of the NSAID (non steroidal anti-inflammatory drugs) kind. These drugs are some of the most widely consumed in the world, and they all inhibit the so-called COX enzymes.

In the present study, healthy 18 to 35-year-old men and women were randomly assigned to two groups, one that took a relatively high dose of NSAID (1,200 mg ibuprofen, which is a normal 24-hour dose) and one a relatively low dose (75 mg acetylsalicylic acid) every day for eight weeks. During the same period, the participants also engaged in supervised weight-training exercises for the thigh muscles two to three times a week. The researchers then measured certain variables, such as muscle growth, muscle strength and anti-inflammatory markers in the muscles. It was found that after eight weeks, the increase in muscle volume, as measured by MR imaging, was twice as large in the low-dose aspirin group as in the high-dose ibuprofen group.

"The results are extremely interesting since the use of anti-inflammatory drugs is so globally widespread, not least amongst elite athletes and recreationally active individuals," says principal investigator Tommy Lundberg, researcher at Karolinska Institutet's Department of Laboratory Medicine. "We chose to look at the effect of ibuprofen as it is the most well-studied anti-inflammatory drug on the market, but we believe that high doses of all types of OTC NSAIDs have similar effects."

Muscle strength was also impaired with high doses of anti-inflammatory drugs, but not to such a pronounced extent. Analyses of muscle biopsies showed that classical markers for inflammation were inhibited in the muscles of the ibuprofen group.

"This suggests that muscular inflammation processes when combined with weight training are beneficial to the long-term development of new muscle mass, at least in the young," says Dr Lundberg. "Our results suggest that young people who do weight training to increase their muscle mass should avoid regular high doses of anti-inflammatory drugs."

The results partly contradict studies in older populations, which have indicated that anti-inflammatory drugs can protect against age-related muscle-mass loss. The researchers think, therefore, that the mechanism regulating muscle mass differs between the old and the young

Story Source:

Materials*provided by*Karolinska Institutet.*Note: Content may be edited for style and length.

Journal Reference:

Mats Lilja, Mirko Mandi?, William Apró, Michael Melin, Karl Olsson, Staffan Rosenborg, Thomas Gustafsson, Tommy R Lundberg.*High-doses of anti-inflammatory drugs compromise muscle strength and hypertrophic adaptations to resistance training in young adults.*Acta Physiologica, 2017; DOI:*10.1111/apha.12948

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Karolinska Institutet. "Anti-inflammatory drugs can inhibit muscle growth." ScienceDaily. ScienceDaily, 28 August 2017. <www.sciencedaily.com/releases/2017/08/170828125123.htm>.

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Anzel
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Thanks.

Nice read anzel, I would recommend tsking your anti inflammatory supps away from training so if you train in the PM take in the AM and Vic's versa. Inflammation is a part of the growing process for us


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Nice write up brother!


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Good post Bro. As a daily user of ibuprofen for chronic lower back pain, this certainly justifies try to use as little as possible.

Originally Posted by Anzel

Anti-inflammatory drugs can inhibit muscle growthDate:The long-term use of over-the-counter (OTC) anti-inflammatory drugs can inhibit muscle growth in young, healthy individuals engaging in weight training, according to a new study.

*****

FULL STORY

The long-term use of over-the-counter (OTC) anti-inflammatory drugs can inhibit muscle growth in young, healthy individuals engaging in weight training, according to a new study from Karolinska Institutet, reporting on the effects of ibuprofen on the skeletal muscles and published in*Acta Physiologica

Most mild analgesic and antipyretic OTC drugs, apart from paracetamol, are of the NSAID (non steroidal anti-inflammatory drugs) kind. These drugs are some of the most widely consumed in the world, and they all inhibit the so-called COX enzymes.

In the present study, healthy 18 to 35-year-old men and women were randomly assigned to two groups, one that took a relatively high dose of NSAID (1,200 mg ibuprofen, which is a normal 24-hour dose) and one a relatively low dose (75 mg acetylsalicylic acid) every day for eight weeks. During the same period, the participants also engaged in supervised weight-training exercises for the thigh muscles two to three times a week. The researchers then measured certain variables, such as muscle growth, muscle strength and anti-inflammatory markers in the muscles. It was found that after eight weeks, the increase in muscle volume, as measured by MR imaging, was twice as large in the low-dose aspirin group as in the high-dose ibuprofen group.

"The results are extremely interesting since the use of anti-inflammatory drugs is so globally widespread, not least amongst elite athletes and recreationally active individuals," says principal investigator Tommy Lundberg, researcher at Karolinska Institutet's Department of Laboratory Medicine. "We chose to look at the effect of ibuprofen as it is the most well-studied anti-inflammatory drug on the market, but we believe that high doses of all types of OTC NSAIDs have similar effects."

Muscle strength was also impaired with high doses of anti-inflammatory drugs, but not to such a pronounced extent. Analyses of muscle biopsies showed that classical markers for inflammation were inhibited in the muscles of the ibuprofen group.

"This suggests that muscular inflammation processes when combined with weight training are beneficial to the long-term development of new muscle mass, at least in the young," says Dr Lundberg. "Our results suggest that young people who do weight training to increase their muscle mass should avoid regular high doses of anti-inflammatory drugs."

The results partly contradict studies in older populations, which have indicated that anti-inflammatory drugs can protect against age-related muscle-mass loss. The researchers think, therefore, that the mechanism regulating muscle mass differs between the old and the young

Story Source:

Materials*provided by*Karolinska Institutet.*Note: Content may be edited for style and length.

Journal Reference:

Mats Lilja, Mirko Mandi?, William Apró, Michael Melin, Karl Olsson, Staffan Rosenborg, Thomas Gustafsson, Tommy R Lundberg.*High-doses of anti-inflammatory drugs compromise muscle strength and hypertrophic adaptations to resistance training in young adults.*Acta Physiologica, 2017; DOI:*10.1111/apha.12948

Cite This Page:

MLAAPAChicago

Karolinska Institutet. "Anti-inflammatory drugs can inhibit muscle growth." ScienceDaily. ScienceDaily, 28 August 2017. <www.sciencedaily.com/releases/2017/08/170828125123.htm>.

Have a good day!
Anzel
Puritysourcelabs.ru representative

Visit Puritysourcelabs.ru or PM me.

Originally Posted by Weapon X

Good post Bro. As a daily user of ibuprofen for chronic lower back pain, this certainly justifies try to use as little as possible.

I suppose you have tried other methods to alleviate your pain
Do you know what causing it?
Have you tried going to a physical therapist that deals with sports injury?
Also things like acupuncture may work.
Also I don't know if muscle relaxers are good to take or not but look into that. Somehow I think they would be best to stay away from

Anzel Puritysourcelabs.ru representative

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Failed back surgery. L4, L5, S1 fusion. Gotten 2nd, 3rd, and 4th opinions. I'm basically fucked. Just have to suck it up and live with it. I'm not going to take any muscle relaxers or opiates. Been there done that and am far better off without them.

Originally Posted by Anzel

I suppose you have tried other methods to alleviate your pain
Do you know what causing it?
Have you tried going to a physical therapist that deals with sports injury?
Also things like acupuncture may work.
Also I don't know if muscle relaxers are good to take or not but look into that. Somehow I think they would be best to stay away from

Anzel Puritysourcelabs.ru representative

Visit Puritysourcelabs.ru or PM me.

Originally Posted by Weapon X

Failed back surgery. L4, L5, S1 fusion. Gotten 2nd, 3rd, and 4th opinions. I'm basically fucked. Just have to suck it up and live with it. I'm not going to take any muscle relaxers or opiates. Been there done that and am far better off without them.

Right...better off taking Advil everyday. Well keep training and take care of yourself maybe in 20 years they will have a miracle fix for you...on that note may be they will have one for all of us!!



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