Actually, when I first started, my doc had me at 75mg one shot per week just to see how it went. Immediately I had aching balls and my left tit was sore. He put me on .5 arimidex per day and that knocked it right down. A year later after some blood work, he suggested we try and wean off the pills. I took them less frequently and over a couple months, I stopped completely and never had a problem since.