Thread: best Igf-1 lr3

If I knew the IGF was legit, I would run it over HGH. We take HGH to get our igf-1 levels to raise so taking igf skips the middle man. Rich Piana has some good videos on youtube explaining his take on it and it makes a ton of sense.

If it was cheap and readily available igf and hgh and tren would be the wonder stack. You get desynthesized to igf fairly quick and need to cycle on and off, but if you ran gh with it you be be fine with that. Tren raises igf as well.

So is anyone going to drop a solid source

it really is all pretty cheap each works out to like a couple dollars a day... unless you over eat your hgh young man lol na but for real its cheaper then a breakfast sandwich everyday and a coffee

ive used our LR3 but not our DES. Used LR3 during my first prep..

we've got a few discounts running

Inclrelex and ipsan I believe is the other one are the only 2 igf-1 peptides I would 100% trust. but the price you pay is quite a bit (40mg for $1600 is the average cost). There are research companies that do have some pretty good igf lr3 and des peptides as well but as jimmyinkedup posted you have to do your homework and make sure they are us peptides and synthesized correctly.

I remembered these threads. I've been running some igf, I'm not going to say what sponser. I still feel the same as before, I think its underdosed. I'm getting strange pumps, but not mind blowing or painful. I worked my back today and I like to reach up really far on lat pulldowns/highrows and get a really good lat strech. I got pumps quick in my biceps which is unusual for me on those and got a little pump in my tricep from extending my arms all the way up. I noticed I was more vascular than usual right after I pinned it and during the workout as well.

Originally Posted by bigtruckguy

Sup bros just trying to locate the best source for some igf... I have heard a lot how most places have bunk igf so if you have had any good igf please let me know.. I have seen it through our sources available here ranging from $40 to $70 but would just like to know if anyone had had any good results...

not as simple as bunk or not, some places are not really sure what they are doing...
here is info I made n posted at another place that might help, I only use 2 places now for years. I agree there is alot of BS out there, anyway here is info, and i have few more threads like it if peopl are interested ill post up:

Why peptides you use should be from a recombinant DNA source and not a chemically synthesized source

I want to bring something up about peptides and peptide quality. I see many people going the cheap route but there is a reason that they may be simply wasting their money. That is why I wanted to start a thread about an issue I think is going on related to efficacy of chemically synthesized IGF and most other peptides vs. recombinantly made ones.

There are many threads on here about IGF-1 and other peps giving good gains and I feel some of it may be BS or the person is having a "placebo affect", while others swear peptides are a complete scam and do nothing at all! (not true)... There might be a reason your igf1 cycle didn't give you jack shit?

Why?

I believe most are purchasing IGF-1 (for an example of a popular peptide being used) made by cheap peptide synthesis companies. However, chemical synthesis of IGF-1 lacks the correct disulfide bonds that cause the proper folding and function in the peptide chain. IGF-1 and its many analogs require 3 disulfide bonds to generate the correct folded form of the protein and this can only be accomplished in the body as naturally produced, or in E.coli bacteria as a recombinant source which is similar to how HGH is made (recombinantly).

Insulin is also very similar to the structure of IGF-1 and it also is inactive and/or unstable if synthesized chemically, it has to be made recombinantly or extracted from a biologic source (they used to extract insulin from bovine and HGH from cadavers).
Made with "recombinant DNA" means it is made in bacteria which have data input into it and "fermented" create enzymes that make these intramolecular disulfide bonds so that the protein folds into the right configuration and has the biological function it is supposed to have, having the proper amino chain is NOT enough and it is NOT that simple!

If you look into human clinical trials or current clinical treatment of patients, they now use some of these peptides as part of a therapy protocol and they use recombinant DNA made peptides, not chemically synthesized ones and for good reason.

Here is just one of many studies on how important the correct bonds are, not just the structure>
Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI > Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI


There are many cheap peptide sellers popping out like CRAZY the last couple years with ridiculously low prices that just doesn't make any sense. So I say if it seems too good to be true, then it probably is!
There is a reason some places are so cheap while others can cost more than 2X or 3X the amount of the cheaper places.

You usually get what you pay for so PLEASE do your research first!

Just because it's pricy doesn't automatically mean its top quality, you still need to research the company.
But if it is really cheap then I would just avoid it because the chances of it being properly made are minimal in this case. IMO

There is a flood of shotty quality peptides coming from china, BE SAFE AND AVOID!

What you want is the more expensive recombinant DNA made peptides! NOT the cheaply made, unstable and largely biologically inactive chemically synthesized peptides!

Many don't even have a clue about all this and that is why I am posting this thread.

Hope it helps someone!


Cheers

Originally Posted by Blergs

not as simple as bunk or not, some places are not really sure what they are doing...
here is info I made n posted at another place that might help, I only use 2 places now for years. I agree there is alot of BS out there, anyway here is info, and i have few more threads like it if peopl are interested ill post up:

Why peptides you use should be from a recombinant DNA source and not a chemically synthesized source

I want to bring something up about peptides and peptide quality. I see many people going the cheap route but there is a reason that they may be simply wasting their money. That is why I wanted to start a thread about an issue I think is going on related to efficacy of chemically synthesized IGF and most other peptides vs. recombinantly made ones.

There are many threads on here about IGF-1 and other peps giving good gains and I feel some of it may be BS or the person is having a "placebo affect", while others swear peptides are a complete scam and do nothing at all! (not true)... There might be a reason your igf1 cycle didn't give you jack shit?

Why?

I believe most are purchasing IGF-1 (for an example of a popular peptide being used) made by cheap peptide synthesis companies. However, chemical synthesis of IGF-1 lacks the correct disulfide bonds that cause the proper folding and function in the peptide chain. IGF-1 and its many analogs require 3 disulfide bonds to generate the correct folded form of the protein and this can only be accomplished in the body as naturally produced, or in E.coli bacteria as a recombinant source which is similar to how HGH is made (recombinantly).

Insulin is also very similar to the structure of IGF-1 and it also is inactive and/or unstable if synthesized chemically, it has to be made recombinantly or extracted from a biologic source (they used to extract insulin from bovine and HGH from cadavers).
Made with "recombinant DNA" means it is made in bacteria which have data input into it and "fermented" create enzymes that make these intramolecular disulfide bonds so that the protein folds into the right configuration and has the biological function it is supposed to have, having the proper amino chain is NOT enough and it is NOT that simple!

If you look into human clinical trials or current clinical treatment of patients, they now use some of these peptides as part of a therapy protocol and they use recombinant DNA made peptides, not chemically synthesized ones and for good reason.

Here is just one of many studies on how important the correct bonds are, not just the structure>
Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI > Role of native disulfide bonds in the structure... [Biochemistry. 1993] - PubMed - NCBI


There are many cheap peptide sellers popping out like CRAZY the last couple years with ridiculously low prices that just doesn't make any sense. So I say if it seems too good to be true, then it probably is!
There is a reason some places are so cheap while others can cost more than 2X or 3X the amount of the cheaper places.

You usually get what you pay for so PLEASE do your research first!

Just because it's pricy doesn't automatically mean its top quality, you still need to research the company.
But if it is really cheap then I would just avoid it because the chances of it being properly made are minimal in this case. IMO

There is a flood of shotty quality peptides coming from china, BE SAFE AND AVOID!

What you want is the more expensive recombinant DNA made peptides! NOT the cheaply made, unstable and largely biologically inactive chemically synthesized peptides!

Many don't even have a clue about all this and that is why I am posting this thread.

Hope it helps someone!


Cheers

Awesome post bro. This clears up a lot. Most people agree that real IGF is awesome but most people also agree that it is mostly faked. I have recently tried some igf myself and got some decent results but none of those crazy pumps and results you read about

We have true recombinant IGF-1 LR3. Very rare to find this stuff at the right quality.