MK-677 HGH Oral SECRETAGOGUE

**Johnjuanb1** · 02-23-2015, 07:27 PM

I think I found my perfect MK-677 protocol finally. 50mg was too powerful and left me groggy.
Last night I took 37.5mg, which is a full dropper worth, with 10mg melatonin. I had the best sleep I've had in ages, and I'm
not groggy today.
The pumps have been so incredible off MK-677 with tadalafil. I'm up 6Lbs in 9 days and haven't had a cheat meal in 6 days.

**Dbolish** · 03-08-2015, 05:25 AM

any further updates?

**MR14** · 03-09-2015, 01:40 AM

Does this require AAS use as well or are you using peptide only cycle? Keep up the updates m8!

**Elvia1023** · 03-16-2015, 11:27 PM

Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men.

Copinschi G1, Van Onderbergen A, L'Hermite-Balériaux M, Mendel CM, Caufriez A, Leproult R, Bolognese JA, De Smet M, Thorner MO, Van Cauter E.

Abstract

To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677. Each period involved bedtime administration of the drug for 7 consecutive days. At the end of each period, plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) were measured at 0745 h, and 24-h profiles of plasma GH and cortisol were obtained at 15-min intervals together with the 24-h urinary excretion of free cortisol. Profiles of plasma free cortisol were calculated at hourly intervals. The amounts of GH secreted were similar in all three conditions, but GH pulse frequency was increased with both dosages of the drug, primarily because of an increase in the number of low amplitude pulses. Plasma IGF-I levels were increased in a dose-dependent manner, whereas IGFBP-3 levels were increased only with the highest dosage. There was a positive relationship between GH pulse frequency and IGF-I increase. Except for an advance in the nocturnal nadir and in the morning elevation, MK-677 had no effect on cortisol profiles. In particular, 24-h mean levels of plasma total and free cortisol and urinary excretion of free cortisol were similar under all conditions. The present data suggest that the use of MK-677 for the treatment of relative somatotropic deficiency, particularly in older adults compromised by such deficiency, deserves further investigation.

Oral growth hormone secretagogues--better than Alice in Wonderland's growth elixir? [J Clin Endocrinol Metab. 1996]

PMID: 8768828 [PubMed - indexed for MEDLINE]

**Johnjuanb1** · 03-17-2015, 03:29 AM

The dreams sometimes are so real taking MK-677 with melatonin they shock me. I had a dream the other night where I composed music and it was flawless, every instrument flowed perfectly together. It was music created in my dream. Why can't I create that music in life? It's mesmerizing that something new can be created by your mind but can't be replicated while awake. It just goes to show how little of our brain we actually use while awake.

Do you guys find higher doses of melatonin increase the vivid dream potential of MK-677?
I've been dosing it at 10-12mg because a buddy told me we can only use 10mg but I'll try 20mg tonight with my 25mg MK-677. By the way, I lowered my MK dose to 25mg a week and I find I'm not lethargic during the daytime off that dose. 25mg is just right.

**Johnjuanb1** · 03-19-2015, 04:18 PM

I'm definitely seeing a reduction in body fat from MK-677 and cjcDAC. My goal is to be 4% by May 1st. I haven't had a cheat meal in 11 days which hasn't been difficult at all because I notice If I get cravings I will take a couple grams of Maeng Da kratom leaf powder and my energy jumps up with no need to eat for an additional two hours until I notice I'm shaking from low blood sugar. I have these amazing 190 calorie quest protein bars if I'm dying for sweets. The chocolate cookie dough bar is amazing!!!!

**Johnjuanb1** · 03-20-2015, 02:22 PM

Happy Fiday...,
Any of you guys have dreams so vivid you get injured in your sleep?
Last night I took 25mg MK-677 and 9mg melatonin after my post workout protein shake, then fell asleep. I dreamed I was attacked by wolves in one dream and rattle snakes in another. I know in the wolf dream I physically tore it apart in a death fight. This morning my middle knuckle on my right hand is very sore when I make a fist and swollen. I must have punched the shit out of the wall. Hahaha talk about vivid dreams.

**Johnjuanb1** · 03-21-2015, 03:35 PM

Just woke up. My hands have been numb throughout the night every night and also while posting online. My hands are tight when I ball them I to a fist too. I haven't had a cheat meal in 13 days so I'm not holding much water. The MK-677/cjcDAC seems to be doing it's thing nicely.

**Johnjuanb1** · 03-26-2015, 04:07 PM

RamboStallone has been teaching me tricks to remove water retention from MK-677. Last night I lowered my dose of MK-677 and my abs look so much better.

Rambo says if I stack 50mcg Igf1-Lr3 with 12.5mg MK-677 before bed then the igf1 will use the subcutaneous water produced by the MK to shuttle glycogen to the muscles causing the duel effect of giving me less subQ water and greater fullness to my muscles. I really like this theory and will be testing it after spring break.

We need a volunteer to get serum hgh blood testing done to prove or disprove whether Igf1-Lr3 inhibits hgh secretion from gh peptides.
The new theory is since Lr3 has 83 amino acids unlike the 70 amino acid igf1 in the body, that it will not negatively impact hgh secretion from gh peps. If this is true then it would be beneficial to add small amounts of Lr3 to all gh cycles.

**Johnjuanb1** · 04-07-2015, 05:55 PM

I've been back on mk-677, ghrp2, and cjc no DAC for 3 days and I've gained 9Lbs. It's obviously water weight but most of it is contained in the muscles so it looks real good. My rotator cuff and knees feel much better from the added fluid.
Next week I'll order more mk-677, ghrp2, cjc no DAC, Hexarelin, Igf1-Lr3, and tadalafil.