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    Thread: Exemestane

    1. #1
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      Exemestane

      I just started exemestane today at 25mg. I never use AI's but am going to see if daily exemestane helps reduce bloat from MK-677. I also want to see how it effects my state of mind. I'm hoping exemestane doesn't Lower my sex drive or dry my joints out. Estrogen reduction is around 30% while testosterone increases around 60% so I'm actually hoping for a sex drive increase with a drier/precontest appearance.


      Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males.
      Randomized controlled trial
      Mauras N, et al. J Clin Endocrinol Metab. 2003.
      Show full citation
      Abstract
      Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14-26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P <or= 0.002); 50 mg, 32% (P <or= 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P <or= 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 +/- 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.

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    3. #2
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      Sex drive is slightly up. That's all I notice so far.

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      I'm holding a little less water this morning. Had a massive erection while sleeping. Sex drive is slightly up still. No joint issues as of yet.

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      Exemestane must be lowering my estrogen because I'm no longer emotional like a female on the rag. My sex drive has been slightly increased since starting exemestane. I use it eod at 25mg taken with a meal.

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      I've used exemestane for long periods of time before, usually at 12.5 mg per day, but I notice benefits even off cycle from exemestane use.

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      Quote Originally Posted by Chimaera View Post
      I've used exemestane for long periods of time before, usually at 12.5 mg per day, but I notice benefits even off cycle from exemestane use.
      It feels much more joint friendly than adex.

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      From bloodwork I've done while on TRT of 125mg test E E4D (~220 test E wk) that keeps me right around 800 on the lab scale, exemestane at 10mg every 12 hours has me right at 10.5 on estradiol. The lower side of the scale but it's working and helps keep the water retention down. I did try to lower my exemestane dose to 6.25mg every 12 hours and noticed water retention went up after about 4 days, so my estradiol must have gotten slightly too high. I went back to my 10mg every 12 hour dosage and things are improving. Looks like 10mg every 12 hours while on TRT works best for me and around 15mg every 12 hours while on blast.
      5'8" 195 4.5% bf

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      I use pharmaceutical Aromasin @ 25mg EOD and it works great. Sex drive is good too, so far its my favorite AI.

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      Quote Originally Posted by bobudafrudo View Post
      I use pharmaceutical Aromasin @ 25mg EOD and it works great. Sex drive is good too, so far its my favorite AI.
      I've been using Blue Sky aromasin and it seems to work well but tastes like wood grain alcohol. Where do you get the pharma? I'd like to try that.
      5'8" 195 4.5% bf

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      The only times I've ever gotten screwed was buying Aromasin. I tried buying it twice from two different labs (big name sponsors on another board) who said they sold it in pill for and it was bunk both times! I literally ate them like candy 200 - 300mg a day for several weeks) and they didn't do shit.

      It's to bad it's so hard to find people who make it and make it right and that it's soooo expensive!

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