I started taking Metformin about a month ago and have not had any side effects. I was taking 500mg 2x a day but going to up it to 3x a day. I have lost about 5 pounds since being on it and really have not cut back on my diet. You get get it for free at the Meijer's pharmacy, if you have a prescription. From reading Dr Osborn's book, it has many other benefits.