Thread: Mk677- The No BS Straight Scoop ....

Originally Posted by Tsquared

Has anyone had any experience running MK along side real gh? Say you pin 4 IUs in the AM and then take 25mgs of MK before bed to maximize my natural pulse at night? I wonder how much that would increase your igf levels compared to just the gh alone

I have talked to someone who was doing just that. They were dosing 4 iu of gh daily in 2iu increments and 25mg MK once a day. When they were tested for gh it was in the 8iu/day range. They said the overall effect was quite powerful, and somewhat different than gh alone would have accounted for. Excellent synergy between them. Supposedly.

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Yes 907rider and Tsquared. I have a whole page in my notes full of various post from others who report the same great results you mention with a combo of low dose GH with low dose MK677. Answer to your question can be found here:

see thread "GH mk677 combo"

GH MK677 combo - Professional Muscle

Mike Arnold:

I think it's a great combo, especially when trying to build muscle tissue. People do it all the time with great results, so it speaks for itself. It saves the person money, stops IGF-1 induced negative feedback from shutting down endogenous growth hormone production, ensures that the body has elevated levels of all the different GH isoforms, and provides a constant supply of GH throughout the day (compared to exo. GH, which only keeps GH blood levels elevated for roughly 8 hours).

MK-677 also has its own unique set of benefits, such as appetite stimulation and greater increases in muscle fullness when compared to exo. GH on an iu to iu basis.

Cybrsage (post #44) said:

MK677 works by telling the body it has to create a GH pulse - so it does. It tells the body to do this 12 (or more) times a day. The GH created by NK677 is the body's own natural GH. Not saying that is better than injectable GH, though. a 25mg dose of MK677 creates IGF levels in a person equivalent to 4IUs of pharma grade HGH.

Yes, I agree with Cybrsage, as what we are finding is that some people using MK677 by itself and having bloodwork done are testing around the equivalent of 3iu of GH, and some lucky individuals are testing as high as the equivalent of 4iu of GH.

I had baseline IGF-1 bloodwork done (227), tested 4iu of pharm grade GH after 3 days (380), and am currently on a 4 week run of 20mg MK677 by itself, when I will have bloodwork done in several weeks to do a comparison as well, when I will report back with bloodwork.

After a week, I am a fan of MK-677, I weigh my own caps (as the taste is terrible) with a 1mg scale, and prefer taking it 1st thing in the morning, function fine on it, have a sense of wellbeing, muscle-fullness + pumps, increased recovery from workouts + anti-aging benefits as I am 48. It does feel like several IU of GH to me. Personally, I sleep very well at night by taking it in the morning. Yes, there is some appetite increase, but the fat percentage has actually gone down by 1% allready on the MK677 + keto diet except for 25g carbs 1 hour pre-workout (always from crunchy peanut butter, glycemic index of 14) and postworkout on workout days. I consume 180g of protein a day, with 50g of that from met-rx daily and fats are kept high. Non-workout days carbs are kept to less than 20g. The peanut butter helps to give me energy for the workout. Also on TRT of 200mg test c a week as well, with 1/8th to 1/4mg armidex twice a week with each 100mg shot. I continue to loose fat while fat free mass is up. Also happy to report that blood pressure is normal. I own two books on HGH: "Grown young with HGH" and "Growth Hormone Secretagogues in Clinical Practice", both books have a discussion about the results and benefits of MK677, and how it was discovered.
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Best article on MK677 I have read with charts and graphs from most of the studies:

The Beauty of Modern Science: Ibutamoren (MK-677):

The Beauty of Modern Science: Ibutamoren (MK-677) - Mind And Muscle
hxxp://mindandmuscle.net/articles/beauty-modern-science-ibutamoren-mk-677/

Here are the results of the research I did so far:
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self:
227 igf1---->380 igf1 (4iu chinese generic pharm grade) = 153 point jump

Peptides:
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Alpha6164's (medical doctor's best friend):
167 igf1---->272 igf1 (100mcg grf(1-29) + 100mcg ghrp2 x 3 times a day) = 105 point increase

MK677:
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Fitraver:
224 igf1---->359 igf1 (12.5mg mk677) = increase of 135 points *
MrSaturatedfat:
232 igf1---->312 igf1 (25mg mk677) = increase of 80 points**
thebigone:
150 igf1---->242 igf1 (20mg mk677) = increase of 92 points***
machine5150:
141 igf1-----217 igf1 (20mg mk677) = increase of 76 points****
Sayitaintsoap:
unknown igf1---->376 igf1 (25mg mk677) = unknown increase*****

*See Fitraver post "bloods on 12.5mg mk677"
**See Mrsaturatedfat post "37 days on mk677"
***See thebigone post "Humatrope,MK677 and other GH labs for you guys"
****See machine5150 post "MK677 Before and After Blood Work w/ IGF Levels Raised 53.9%"
*****See sayitaintsoap post "THT's MK-677 review and blood work"

**Notice the similar point jumps between peptides and mk677, either one seems to reach a max of around 100 igf-1 points.

I am currently running only 20mg mk677 all by itself for 3 weeks, then will get bloodwork, and post the results. Then I will run only 4iu of GH by itself for a good 3 weeks, then post results, so that I can get a more stable long-term igf-1 reading. Would love to see the comparison.
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A few favorite quotes on Mk-677 at lower dosage:

Cybersage (from forum):

Yes, Fitraver saw an over 100 point increase while running it at 12.5mg (half dose)

Sandpig: (9/6/2017)

Drop down to 12.5 . Eventually the lethargy and other issues will slowly fade. Once they do, you can bump it up again. Took me two months at 12.5 before I could go to 25.

Elvia1023: (19,000 posts)

Everyone responds differently but 25mg is far too much for you. Others are fine at that dose but most aren't. I would recommend 10-12.5mg and with that the side effects will be minimized but the results still there. You won't be as full and pumped but you will feel multiple times better. 10-12.5mg is great for muscle fullness, pumps, recovery, size and strength. I am fine at 10mg but once I get to 15mg and over I can barely function and the fatigue is unbearable. I actually prefer MK-677 to HGH in many ways... especially for gaining size.

RamboStallone (9/6/2017: 7,000 posts):

This is why I personally recommend starting at 5mg. MK677 increases gh/igf levels for a 24hr period from a single dose, this is longer than any other peptide or GH product, and in my opinion stronger than any gh supp including exogenous GH. I've used this stuff for years now and everytime I restart it anything over 5mg puts me on my ass. It's all the sides of increased gh/igf just more pronounced with MK677 then any other gh product including the effects. I blow up on the stuff immediately. The cts is unbearable. My recommendation, lower the dose brother.

Additional information on peptides only (for comparison purposes):

Alpha6164 (medical doctor and bodybuilder, from the long 60 page thread at prof muscle, he performed nearly a dozen bloodtests and charged them to his medical practice):

I dont think peptides in usual 2-3x daily can equal 5iu of quality GH daily. Here is why. When i was on 5iu of Rips daily, my IGF was in the 600s. That is coming from a baseline of 160s. We know from three different tesamorelin studies that 2mg of tesamorelin raised IGFs 109-180 from basline. So if i started with 160 i could go to 260-340. Now that is a great number from baseline and can be almost a 200% increase and you will get fat loss benefits, anti-aging etc. But definitely not in the range of 5iu of synthetic GH.

My best friend and partner was on 100/100mcg of GRF/GHRP-2 three times a day and his IGF increased about 120 from baseline. So very in line with 2mg of tesamorelin.

Alpha6164 said

My best friend used GRF1-29/ghrp-2 100/100 three times daily and his IGF went from 167 to 272 in 8 weeks. Yes we are not getting IGFs in the 500-700s as with high dose GH but having a rise of 40% on such a small dose is pretty significant.

Alpha6164 in conclusion said:

Peptides will raise your GH as if you were on 2-3iu of synthetic GH daily. So it is great for people that wanna be on anti-aging dosage or for fast loss purposes.

Using a 100/100mcg combo 3x daily will raise your IGF similar to if you were on 2-3iu of GH daily. Most people on 4iu of GH will have IGFs in the high 300s to low 400s. But raising your IGF by 100-150 points from baseline can only help you with better recovery, healing, metabolism etc.

1st lab is baseline igf-1 [227, high] (age 48, ref is 67 to 205 ng/mL)

2nd lab is igf-1 [380, high] after being on 4iu of Chinese pharm grade for only 2 days (95 point increase per each 1iu)

3rd lab (upcoming in 3 weeks) is igf-1 after being on 20mg of mk677** (by itself) for 3 weeks

** note: taking 20mg mk677 by itself in morning with 200mcg huperzine A + NOW brand EGCg caffeine free green tea extract--400mg (contains 200mg EGCg/80% catechins, using these to help keep somatostatin down).
lab.jpglab11.jpg
Note: I have been taking the mk677 at 20mg in the morning only and sleep very well at night (normal 8 hours plus), vivid dreams are often noticed (similar to GH). I get disrupted sleep (get less sleep) when I tried taking it before bed or even a few hours before bed, Keep in mind that the body needs some time to adjust to the compound I think as well. I had problems with lethargy in the past (when I tried mk677 months ago for a few days, then gave it up) since I was taking it at night and getting less sleep which I think led to tiredness during the day at work. My body does not react well to taking anything before bed. But when I take the MK677 in the morning, I get a good sense of well-being every day (my spouse even said I had been coming home every day after work in a good mood, and that she loved the change) and no lethargy issues thus far after a week. Everyone is different and you have to find what works for you. Mike Arnold also reported he gets no lethargy on it, so I guess everyone responds differently. Water retention does not seem to be too bad from the compound while being on a low carb targeted keto diet.

So I got the results back from the bloodwork after being on 25mg of mk677 only for 2 weeks, and the result was 372 ng/ml.

That's an increase of 145 points from baseline!

227 baseline igf-1----->380 igf-1 after being on 4iu of Chinese pharm grade GH for 2 days

227 baseline igf-1----->372 igf-1 after being on mk677 only for 2 weeks.

So, in conclusion, being on mk677 for 2 weeks was similar to being on 4iu of Chinese pharm grade GH, for me anyhow, as the bloodtest proves it.

This is an incredible raise in igf-1 for my age of 48 as reference is 67-205 for my age group, and the mk677 for 2 weeks brought me beyond the high range for a young adult in their early 20's.

I couldn't be happier, this helps explain the increases in strength at the gym, as well as the fast recovery from workouts.

MK677 should bring you to the high level of a young adult if you are already at the high end for an older adult.

Older folks (59-225ug/L)
young adult (116-358 ug/L)

Ref levels from the MK677 study on healthy older adults.

So I could not be happier that MK677 brought me beyond the very high level range for a young 20 year old. I could only imagine what it could do for a 20 year old.

Mk677 at 25mg a day cost me only 15 a month for the pure powder vs 170 a month for 100 iu of pharm grade Chinese GH at 4iu for 20 days, so the cost savings is quite substantial, and shows that a person could even alternate the two from month to month (say 5iu GH only one month, 25mg mk677 only the next month) should they desire to save money, or just stay on mk677 to remain at a 4iu GH level.

p.s. keep in mind I took 25mg of mk677 every morning along with huperzine A and EGCG just once a day of both. You could also use CDPcholine and vitamin B5 in place of the huperzine A, this all helps to lower somatostatin.lab.jpg