Thread: GH Relseasing Systems Simplified (by datbtrue)

If you can only afford one peptide you choose a GHRP (either GHRP-6, GHRP-2, Ipamorelin) and you dose it at saturation dose (100mcg). You may use it pre-bed, or prebed + post workout, or prebed + postworkout + morning.

You are much better served if you can add Mod GRF(1-29) to your GHRP. If you can afford it you dose 100mcg of Mod GRF(1-29) + 100mcg GHRP prebed. You may add a PWO dose and a morning dose.

If you want you may cut the dosing back toward 50mcg of each.

If you want you may dose up to 5 times per day at 100mcg/each or 6 times per day at 50mcg/each.

The Mod GRF(1-29) is the only GHRH you should consider. The GHRPs can be used anyway you want. You can use Ipamorelin at night and GHRP-6 or GHRP-2 at the other dosing, for example at 100mcg.

You could do as you described use a mix of Ipamorelin and GHRP-2 (or even GHRP-6) in a single dosing. If you do that you would generally choose saturation dose which equals 100mcg and you would fill that dose with various GHRPs. For example 50mcg of Ipamorelin and 50mcg of GHRP-2.

You may if you choose bump up your dose of GHRPs to 150, 200, 250mcg. But my experience is this:

Frequency is PREMIUM. It is far more beneficial for all body shaping goals to dose at either saturation (or half saturation if you are younger) 3-5 times per day then it is to take 2-3 doses of twice or thrice saturation doses. Most people do not believe it and I believe it is because they are not using the same peptide quality as they use in the medical/clinical studies.

100mcg of Mod GRF(1-29) + 100mcg of GHRP from Tom has a very powerful effect. With those peptides you could cut the dose to 50mcg of each and dose 3-5x a day and get a much better benefit then if you use "weak soup".

You have plenty of toggling choices as well. On days devoted to fatloss you could use half saturation dose but dose more frequently (5-6 times per day at 50mcg Mod GRF(1-29)/50mcg of GHRP). On anabolic days you could dose at the saturation dose levels. Many ways to go about it.


and the follow up on that part...:


To your question. Although GH does not seem to play a necessary role in daily feed/fast cycles, it is an important fuel metabolic regulator when insulin is suppressed. Growth Hormone becomes THE critical and indispensable mechanism for the starvation-induced increase in the rate of lipolysis.

In studies insulin suppression alone was not able to accelerate lipolysis when GH secretion was low. That's why I have focused so intently on either fast periods or keep insulin quiet periods together with growth hormone. That's the environment where growth hormone can make its contribution to body shape change. BUT it needs to be pulsatile!

GH pulsatility is the underlying mechanism regulating human lipolysis. I have stated it in various ways so many times, the expression is so simple ...yet it is overlooked... It is hidden in plain view and yet is a secret. There are people that came before me (none on the Internet) that were able to whisper to me based on their experiences...I didn't come blind to this... And the science bears me out. A grouping of studies I will write on and document has found minor activation of lipolysis upon continuous GH infusion, but far more "robust lipolytic activation" with pulsatile GH delivery in lean humans.

If we move to the studies on obese (but applicable to anyone carrying too much fat IMO) we find that the reason GH levels are low is as a protective mechanism. The approach where doctors prescribed GH elevations ended up being without any effect in regard to lipolysis. Only the pulsatile GH secretion increased the lipolytic rate.

It is becoming apparent that it is the manner in which GH presents itself to peripheral tissue that is important. This is not to say that elevations have no effect. They certainly do but that is primarily in regard to systemic igf-1 and insulin resistance. Doesn't mean that this is even a bad thing at times in a bodybuilder...

...that still needs to be teased out. But it underscores two things.

One fat loss or rather GH's contribution to it in both lean and obese is dependent on setting up a protocol where insulin is absent and GH pulsatile. There is no mystery to why people who have used growth hormone elevations all these years had to wait to see results or results were good at first and then later not so much. They just did it wrong. Again we have some benefits from GH such as nitrogen retention that they surely received from elevations, but looking in the mirror was not so dramatic because they did not use pulsatile approaches.

When you use clinical grade Mod GRF (1-29) (the best analog of GHRH (Growth Hormone Releasing Hormone for humans) and Ipamorelin, GHRP-6, GHRP-2 (various GHRPs (Growth Hormone Reasing Peptides)) you are obviously pulsing just right. As we move to more frequent pulses the subjective differences between people becomes apparent. Some people can pulse more frequently without the effects resembling elevations. Remember that elevations change the making of many liver enzymes and skew that toward a feminine profile. A profile that even women do not want too much of because it begins to have an impact on the ability to metabolize environmental variables. Those who have a fragile make up already may see an impact more readily then others. As an example, it might become more difficult to metabolize some preservatives such as msg without a youthful pulsatile GH release.

Others will handle increased pulses without having peripheral tissue see it as an elevation. Why how? Genetic differences... When we look at bodybuilders and say "he/she is genetically blessed" it probably means many things... One of which is how they respond to GH... In the speed with which they remake it, secrete it and use it.

The reason I used two different examples 100mcg and 50mcg doses was to underscore this subjective variation.

Carbless Post Work Out and Intermittent Fasting

The first concept is my favorite eating style, the “Carbless Post-workout” protocol, for which I give credit to my friend DatbTrue[2]. There are some rational and scientifically-based reasons for not consuming tons of carbs post-workout.

One is that training heightens insulin sensitivity and consumption of carbs lowers insulin sensitivity.[3] By training and eating carbs, you are undoing some of the benefits you would have reaped. Insulin sensitivity, as stated by Larry, may not be a “big rock,” but it should be a lifelong priority – that is, if you find prevention of diabetes, possible prevention of Alzheimer’s disease, prevention of metabolic syndrome, ability to gain muscle rather than fat, and longevity important![4,5] And even cooler, if you’re a meathead, is that you increase muscle protein synthesis post-workout by avoiding carbs.[6] If you already fast, fasting the day after you train and use CPWO will increase lipolysis and fat oxidation – in other words, you will be able to use your adipose tissue (fat) more efficiently as fuel.[7]

CPWO is pretty simple; you don’t eat carbs post-workout, of course. Instead, you consume large amounts of protein and (depending on goals) moderate amounts of fat. The carbless period lasts from 5 to 48 hours (again: depending on goals) and I typically advise eating “to appetite” – in other words, you eat until full but not stuffed. This serves two purposes. One, satiety is a “good thing” for wellbeing and fat loss, because if you are full there is less chance of noncompliance with your eating plan; and two, because your food selection is limited to the more-filling, less-insulinogenic protein/fat macronutrients, you can stick closer to maintenance or even a deficit (and, for that matter, your body can still begin the recovery process in a slight deficit).

There are some major differences between CPWO and a “keto” (ketogenic) eating plan. First of all, CPWO does not attempt to use ketosis as a primary fat loss modality. Ketosis is great if it occurs, but it does not need to – you can still lose fat and do great if it does not. Second, instead of randomly-planned “refeed” days, CPWO utilizes planned and targeted “carb-ups,” always before some sort of physical activity. If you are training with weights, you always carb up. The day of weight training, eat 1 to 4 meals containing carbs and protein (limited, incidental amounts of fat are OK too) prior to training. As a guideline, you should get in 75-400g carbs total depending on your size, goals, and experience – play around and see how little you can get away with and still have a good workout, or how much you can eat and not put on fat, etc.

First, a few words about glycogen and carb consumption. For years, and to this day, supplement and “recovery drink” companies push sugary post-workout drinks on people who lift weights and do sports, to “replenish glycogen.” In fact, people argue about the “speed” of various carb sources to replenish glygocen as if speed were of the essence. But replenishing muscle and liver glycogen is not necessary to induce protein synthesis or recovery; in fact, there is no need to replenish glycogen until the next physical activity session, if then.Here are some guidelines to determine if you need carbs pre-activity. And remember, you never “need” carbs post-activity, unless you have another session a few hours away (e.g. during a day of competition).

You need carbs priorto exercise if:

-The majority of the upcoming session is resistance training
-Performance is a top priority, such as during a competition
-Your body is very inefficient at using fat for fuel and you “crash” easily (NB: if this is you, try to taper off the amount of carbs you consume gradually, over weeks or months)

You do not need carbs if:
-Fat burning is your primary goal
-You are training, but not competing during this particular session (BJJ, cardio, etc)

If you perform the majority of your non-weight-training activity in a fasted state, you will improve your insulin sensitivity and ability to use fat for energy, and - if the big rocks are in place – will be healthier and leaner.Here is a quick and dirty template with a few additional points:

-Pre-lifting, consume 75-400g carbs divided between 1-4 meals with 20-50g protein at each meal (more meals is better, but some people are forced to lift early, or don’t have time to eat more meals, etc). You should eat the last meal preferably no sooner than 1 hour before the workout.

-I advise consuming L-leucine during the workout due to the vast array of benefits on body composition, etc. [8] Consume 5g during the workout and nothing else. (NB: dat would suggest glutamine and perhaps some glycine here for max benefit)

-Immediately post-workout, consume 40-100g of protein only (depending on body size and goals) from whole foods or shake (this is the one time I typically ever have a protein shake).

-Whenever you are hungry past that point, for the following 5 to 48 hours, consume protein from whole foods, and zero carbs except from raw veggies. It is advisable to eat healthy fats (coconut oil, EVOO, avocado oil, fish oil, a few almonds, almond butter, eggs, butter, etc) at every other meal (amounts will vary depending on whether goal is mass gain, or fat loss).

-Before your next serious, performance-oriented activity session, or your next weight-training session, preferably the “day of,” repeat the “carbing up” process.

-You will probably have better results from fasting if you also use CPWO, and if you position the fasts to be on the day following weight training. Over time it will get easier to fast, too.

Commenting so i can find this tomorrow. Read a bit and so fsr a good read. Thanks

Assistance with Alternate Day Fasting

I find alternate day fasting pretty painful. I get headaches and just feel terrible. DatBTrue advised me to use the following to help curb the side effects of fasting.

Mix the following fiber combination with some water and drink it ot curb the hunger.

1/2 teaspoon - Guar Gum
1 teaspoon - Psyllium Husk
1 teaspoon - Apple Fiber/Pectin

You will want to mix and drink quickly because the longer it sets up the more it gels. It will turn into a near jello consistency if you wait too long. As far getting the fiber, Dat turned me on to herbsfirst.com. I buy 8 oz of Guar, 16 oz. of Psyllium, and 16 oz. of Apple Pectin when I order. Buying it like this helps me to remember the ratio. With shipping its under $70. Hopefully I don't get in trouble for posting a source since its just fiber.

Happy Fasting,

CJC4ME

ghrh and ghrp.jpg

Chart of GHRP & GHRP sinergistic affect.PNG

Growth Hormone Administration vs. CJC-1295 and GHRP-6

Units of Measurement
Growth Hormone (GH) like other biologically active substances is measured in International Units (abbreviated as IU) which are based on the measured biological activity for that substance the establishment of which is determined by international agreement. International Units are specific to each substance and so one IU of one substance has no equivalence to one IU of another substance.

While it is fairly straightforward to compare the amount of GH among various dosing administrations (a two (2) iu dose is twice the amount of a four (4) iu dose) and it is easy to ask the manufacture the weight of each iu (Nutropin reveals that 1 iu of their GH is equal to 333 mcg) it is not so simple to compare Growth Hormone to other "Growth Hormone Releasing" compounds such as CJC-1295 and GHRP-6.


Practically all studies that use Growth Hormone (GH) or Growth Hormone Releasing Hormone (GHRH) or its analog CJC-1295 or Growth Hormone Releasing Peptides all take blood samples to measure the amount of GH present in blood plasma at various points in time. The unit of measurement is a standardized unit which can be used to make comparisons across different compounds.
The studies either report results as "nanograms (ng) per milliliter (ml)" or "micrograms (ug) per liter (L)". For the reason that ng = 1/1000 ug and ml = 1/1000 L, ng/ml will always equal ug/L. So no matter how the studies report results comparison is straightforward. In making the cross-comparisons contained herein for simplicity I have chosen to report results as ng/ml.
Therefore this examination will look to several studies involving administration of the compounds of interest and compare the blood plasma levels of IGF-1 and both peaks and total amount of GH blood plasma levels as a result of administration of each tested compound. The result of this cross-study examination will reveal the efficaciousness of various doses of GH, CJC-1295 and GHRH + GHRP-6 in increasing GH & IGF-1 in blood plasma.


Studies used for comparison

Growth Hormone Administration
In "Pharmacokinetics and Metabolic Effects of High-Dose Growth Hormone Administration in Healthy Adult Men", Toshiaki Tanaka, et al., Endocrine Journal 1999, 46 (4), 605-612, fifteen healthy normal Japanese adult males aged from 20 to 27 years were administered various doses of recombinant GH (Norditropin). The GH was administered in a single dose at 9:00 a.m. after overnight fasting. Blood samples were collected at 0, 1, 2, 3, 4, 5, 6, 9, 12 and 24 hours after the single injection.
The doses administered were: .075iu/kg; .15iu/kg and .30iu/kg
When the average weight of each test subject is accounted for the doses administered approximated: 5iu; 10iu and 20iu


CJC-1295 Administration
In "Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults", Sam L. Teichman, et al. Journal of Clinical Endocrinology & Metabolism 91(3):799-805, sixty-six healthy normal men and women aged 21-61 were administered various doses of CJC-1295 (long-lasting GHRH analog). The CJC-1295 was administered in a single dose and again in some groups 7 days later and other groups 14 days later. For the reason that we are only examining a week's worth of data only the initial dose is of interest. Blood samples were collected before dosing and then at 15, 30, and 60 minutes and 2, 3, 4, 6, 8, 10, 12, and 24 hours afterdosing; and then every 8 hours on days 2–3, then daily on days 4, 5, 6, 7.
The doses administered were: 30mcg/kg; 60mcg/kg; 125mcg/kg; 250mcg/kg

GHRH + GHRP-6 Administration
While we are limited in our choice of GH administration studies (because no other study administered such high doses in normal men) and CJC-1295 studies (there are only two, the results of which are available to the public) we have many available studies measuring the effects of co administration of GHRH and GHRPs.
So we will briefly look at the results from two studies to give us an idea of how much GH release is contributed by the enhanced pulse brought on by this synergistic combination.
They are, "Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing's syndrome", Alfonso Leal-Cerro, et al., Clinical Endocrinology 1994, 41 (5) , 649–654 and "Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone", Bowers, C.Y., et al. J. Clin. Endocrinol. Metab. 70, 975–982.

What's Normal?
Before we look at the studies lets take a brief look at how much growth hormone (GH) is secreted naturally. There is a large variability among age groups, gender, fitness level and among individuals within a single age group. So the best we can do is generalize. The charts below are derived from GH blood plasma data collected over a 24 hour period for a normal man, a normal man after a fast, a normal woman and a normal woman after a fast. All ages were mid-20s.
Note that the night-time GH pulse peak for a man was about 20 ng/ml (aprox. 85% of 24hr GH release normally occurs at night).

Total GH release was as follows:
Men (Fed): Area Under the Curve (AUC): 94 ng/ml per 24 hours
Men (Fasted): AUC: 274 ng/ml per 24 hours
Women (Fed): AUC: 168 ng/ml
Women (Fasted) AUC: 264 ng/ml per 24 hours


Comparing GH administration to CJC-1295 administration
It is difficult to compare based on the following GH release graphs so let's examine the numbers.

Total GH Release:
When GH was administered at 5iu, 10iu & 20iu the total GH levels (area under the curve (AUC)) were respectively:
AUC: 311.5; 836.9; 1778.5 ng/ml per 24 hours

When CJC-1295 was administered at 30mcg/kg; 60mcg/kg; 125mcg/kg and 250mcg/kg the total GH levels (area under the curve (AUC)) were respectively:
AUC: 758; 969; 977; 1370 ng/ml per hour

NOTE: This is per hour while the GH study is per 24 hours

So based on the total GH concentration in blood plasma the lowest dose of CJC-1295 on a per hour basis results in more than twice the 24 hour GH secretion level of a 5iu dose of GH.

Peak Concentration:
However the GH release pattern results in a much higher mean maximum concentration for the GH administration than the CJC-1295 administration.
The GH study resulted in dose respected peaks of 55.4; 93.8; 180 ng/ml

The CJC-1295 study resulted in dose respected peaks of 6.6; 9.6; 9.9; 13.3 ng/ml

The graph indicates that for the GH study the bulk of the peak lasts about 12 hours followed by low levels of GH. As an aside clearly GH administration would be better if it were administered in at least two doses per day.

But even IF 5iu of GH were administered in the morning followed by 5iu twelve hours later the total amount of GH released would be less than a low dose of CJC-1295 (311.5 + 311.5 < 758 ng/ml). Furthermore the CJC-1295 was dosed just once in seven days while the GH would need to be dosed every one of those 7 days.

IGF-1 Levels:

CJC-1295 elevates IGF-1 within the first day or two where it stays elevated for seven days.
GH elevates IGF-1 levels immediately where it stays elevated throughout the rest of the day.
Both the GH & CJC-1295 studies demonstrated a dose dependent increase in elevated IGF-1 levels. The highest GH dose of 20iu resulted in a similar IGF-1 level as the highest CJC-1295 dose. The lowest GH dose of 5iu resulted in an IGF-1 level not much different then the lowest CJC-1295 dose.
Again the CJC-1295 elevated IGF-1 for seven days from a single administration while GH would likely need to be dosed everyday (perhaps every other day) to match CJC-1295's chronic elevation of IGF-1.



Can CJC-1295 plus GHRP-6 match GH adminstration's peaks?
Adding GHRPs to CJC-1295 three times a day can amplify peaks and greatly add to the total GH secretion level.
The Alfonso Leal-Cerro study demonstrated the following GH release:
GHRH by itself dosed at 100mcg resulted in: (AUC) 120 minutes = 1420 * 330 ng/ml
GHRP-6 by itself dosed at 100mcg resulted in: (AUC) 120 minutes = 2278 * 290 ng/ml
GHRH + GHRP-6 dosed together at 100mcg each resulted in: (AUC) 120 minutes = 7332 * 592 ng/ml
By adding GHRP-6 to CJC-1295 (long-lasting GHRH) it may be possible to add almost 6000 ng/ml of GH release at each GHRP-6 dosing. [Figure arrived at by taking synergy amount 7332 and subtracting GHRH's contribution of 1420]
But what about those peaks?

Clearly adding GHRP-6 has the effect of matching GH's peaking power as measured by amplitude. The difference is that GH results in big hills lasting up to 12 hours. This really amounts to an elevation rather than a pulse. GH does not mimic the physiological pulsatile release of GH that naturally occurs while GHRP-6 particularly in the presence of GHRH does result in such a natural pulse. These pulses last for about 2 hours. If dosed three times a day the result would be three 2-hour pulses each of which exceed GH's 5iu and 10iu elevations and approach GH's 20iu elevation.
However 6 hours total of peak for the CJC-1295/GHRP-6 combination would be half of the 12 hours total of peak for the GH.
I do not know if it matters. I do not know if these two different peaking characteristics would result in different effects concerning growth

In CONCLUSION, CJC-1295 appears to result in higher concentrations of GH in blood plasma than does GH administration. When CJC-1295 is combined with GHRP-6 the total GH release is exacerbated.
GH administration results in higher GH maximum concentration or peaks then CJC-1295 alone. However when CJC-1295 is combined with GHRP-6 the peaking amplitude exceeds the 5iu & 10iu GH doses and approaches the 20iu dose. GH administration's peaks however last for 12 hours while CJC-1296/GHRP-6 results in a natural 2 hour peak at each dosing (i.e. 6 hours total).
Both CJC-1295 and GH appear equally effective at elevating and sustaining IGF-1 levels

CJC-1295 unleashing The Beast by increasing GH 10 times

So you want to look like the Hulk or maybe you just want to be lean and muscular. So what’s actually stopping you? Genetics… but what exactly is limiting your muscle growth, while at the same time limiting the burning of fat. Quite simply the answer is Myostatin. Myostatin is a direct negative regulator of the amount of skeletal muscle you have and how lean you are. Studies have proven this using mice with the myostatin knock out gene in which they don’t have myostatin to limit muscle growth. These Mighty lean ripped mice are called double muscled and they look like mice on steroids, all without working out. The prized winning Belgian Blue and Piedmontese cattle have mutations of myostatin resulting in double muscling. Mutations in humans have been shown too have the same results.

So what is CJC-1295 and what does it have to do with myostatin you ask… CJC-1295 is a long acting synthetic version of Growth Hormone Releasing Hormone (GHRH). 30mcg/kg to 60mcg/kg doses can increase gh levels up to 10X normal for 6 days or more with plasma IGF-1 concentrations by 3X for 9-11 days. The estimated 1/2 life is 5.8-8.1 days. After multiple doses the mean IGF-1 levels remain above base level for up to 28 days. Results show that 30mcg/kg CJC-1295 is equal to 5iu’s of gh without the normal negative side effects from taking gh. In essence its much better to use CJC-1295 to make your body produce its own gh instead of taking a synthetic gh that also shuts down your normal production. So how does CJC-1295 and Myostatin relate. Growth hormone directly regulates myostatin. As growth hormone rises, myostatin lowers, which unleashes your potential for muscle growth. As myostatin lowers glucocorticoids effect on fat storage and muscle breakdown lowers. CJC-1295 dramatically raises gh levels which will dramatically lower myostatin which in turn will lower the effects of glucocorticoids fat storage and muscle breakdown. Now you know what has changed that has turned the Pro’s into Freaks.

Steroids GH Myostatin Link

Read this study carefully, it will show that raising testosterone to supraphysiological levels increased pulsatile gh secretion. Supraphysiological is the key word here, cause anything less has no effect. Supraphysiological Test Levels increase GH

This study shows that androgens directly increase gh output without estrogen. Androgens directly increase GH

Raising Testosterone levels lowers Growth Hormone Binding Protein. This protein binds up excess gh. Testosterone lowering GHBP if you read the full text you will figure out that it’s the spike in Test levels above normal from the shots that lowers GHBP proving that supraphysiological test levels raise gh and lowers GHBP

As you can see androgens can directly and indirectly raise growth hormone levels resulting in lowering Myostatin which you already learned increases muscle mass. On a side note leptin has a huge role in fat storage and as gh raises, leptin lowers. I won’t delve into discussing leptin cause it can be complicated so do a search to learn more…

CJC-1295
Anti-Aging
Lets go beyond muscle building and fat loss and discuss the well documented anti-aging benefits of growth hormone. Since this info is so plenty full online I’ll only outline the known benefits and let you fulfill you quest for Anti-Aging by doing your own research. The rate of GH secretion from the pituitary gland is at its peak around puberty, declining progressively as we age beyond that point. Around the late 30s and throughout the 40s, GH levels continue to dip considerably, causing the telltale signs of aging to appear. Fat tissue begins to collect in areas where it may have not before, the skin begins to lose thickness, bone mass becomes depleted, energy levels drop, and mental clarity may become clouded.

For the purposes of anti-aging therapy, GH treatment functions to re-stimulate cell production to youthful levels restoring form and function to the entire body, from the inside out. Those who have undergone successful anti-aging treatment with GH or a combination of GH and other diminishing hormones such as testosterone have been reported to experience improvement in the skin’s appearance, renewed energy, mental acuity, invigorated health, enhanced sexual function, an overall sense of well being and a more youthful lean muscled look. Hundreds of studies have been done on the controlled administration of true HGH in adults. It has been shown to raise energy levels, enhance lean muscle development, decrease body fat, strengthen the heart, improve cholesterol and triglyceride levels and HDL/LDL ratios, fortify bones, smooth out skin wrinkles, sharpen memory, improve sexual function, regenerate damaged tissue, strengthen the immune system as well as improve sleep.

Somatotropin (HGH) from the pituitary gland works by stimulating protein production and synthesis in all tissues of the body. This results in an increase in organ healing and regeneration, which is associated with increase resistance to illness and injury.

In the skin, documentation regarding somatotropin (HGH) supplementation has shown increased collagen synthesis, which makes the skin thicker and smoother. In the bone, these studies showed increased bone density. In the internal organs and sex organs, research showed increased size and markedly improved function.
The immune system, research also showed increased immune system regulation and activity, resulting in fewer infectious illnesses. In adults, HGH is necessary for proper repair and regeneration of injured tissues.
One of the widely reported results of somatotropin (HGH) supplementation is the effect it has on the body’s sexual centers. Research shows heightened desire and function in both men and women.

Beginning around the age of 20 years old, our natural production of somatotropin (HGH) begins to decline at the average rate of 14% per decade.
By the age of 40, somatotropin (HGH) production has decreased 30% over our youthful production level, and by the age of 60, by 80% on average. The decline in somatotropin (HGH) correlates with many of the effects of aging including loss of lean body mass (muscle, bone, skin and internal organs), increase in total body fat, thinning and wrinkling of skin, decreased immune function and decreased sexual desire and function.
As a result of the decline in somatotropin (HGH), and because it is the master hormone, other hormones also decline with age, such as Testosterone, Estrogen, Progesterone and DHEA, as well as many other important mood-elevating hormones. Examples of other hormones that also decrease are thyroid and thymus hormones, which can cause menopause in women and andropause in men.

Growth Hormone can:

Restore muscle loss
Increase skin thickness
Reduce total body fat
Improve bone density

People have seen specific improvements from using HGH in:

Skin tightness and moisture
Mental speed and clarity
Enhanced sexual function
Elevated mood and energy levels
Improved aerobic capacity
Significantly greater immune function
Increased wound healing capacity

So, gh therapy sounds great for anti-aging so what’s the catch… The catch is keeping your levels in a physicological level and to not exceed youthful levels. As with any hormone, raising levels above youthful normal levels can cause unwanted side effects which are easily noticed like joint problems, the development of carpel tunnel and excess water weight gain. Its simple, just lower your dose if you notice a problem. There is a huge difference between keeping levels well above normal for years for anti-aging and doing a cycle with gh/cjc-1295 that exceed normal levels. Short term higher levels have much less potitential to cause long term problems… Ok, so you are interested in anti-aging with cjc-1295, what dose should you use. When taking into consideration the studies on it’s outcome of gh production, as little as 1mg weekly is needed and no more then 2mg a week. This makes CJC-1295 extremely cost effective. Vials could be shared with fellow researchers if only 1mg is used weekly. The lab states after reconsituting cjc-1295 it can be refrozen to be used later but is best used without refreezing, so there may be a slight potiency loss by doing this.

Dosing for Muscle Growth

In the studies 30mcg/kg or 60mcg/kg were used resulting in 2-10 fold in gh production. A 200lb man weighs aprox 90kg… thats 200 divided by 2.2 = 90 so thats 30mcg X 90=2700mcg=2.7mg or 60mcg X 90=5400mcg=5.4mg weekly these doses showed safety… I believe a minimum 2mg a week should be used and no more then 6mg… You decided but I say start low and work your way up to the dose you are comfortable with and remember to keep this short term to reach a specific goal and then go on an anti-aging dose between cycles which would also preserve the muscle growth you build during the cycle.

Stop Wasting Your Money On GH

..CJC-1295 Is More Effective
..costs much less
..less side effects because its your natural gh
..doesn’t shut you down
..Increase Natural GH 10X
..unleash
..Anti-Aging Benefits

Storage: Refrigerate… 18 months + storage in the fridge
Reconstituted: After reconstituting with Bacteriostatic Water use within 6-9 days