Dependes on the person. And the length of the cycle. I do like 2 week on, 4 weeks off. From what i have read it can actually be beneficial to ur body. Because it gives ur body a break from always having to try and maintain blood sugar levels. I give a long break in between each cycle to allow my body to rest and start producing its own. I think i am only gonna cycle 1 week on and 3 - 4 weeks off from now on to lower my chances of becoming dependent.