I've been asked more then several times if IGF1 should be combined with GH, and why not to take it by itself or instead of GH usage ?

In a nutshell the ideal solution is using GH in combination with IGF1-lr3 and/or IGF1-DES
It's true that the IGF1 is the mediator for most of the anabolic effect of the GH, but we must consider 2 things -

  1. The GH has some direct metabolic effect by itself, both in releasing glucose and fatty acid into the circulation, and by this raising metabolism and releasing available energy for anabolic demands, The GH has also a direct effect on nitrogen balance not through the IGF1 path
  2. The IGF1 itself has a direct suppressing effect on the endogenous GH release - so if u inject exogenous IGF you actually and directly suppress any GH present in the circulation

So the ideal solution is combining them both and by this keep optimal serum GH and IGF1 levels