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    Thread: GH, IGF1 and should I combine them ?

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      GH, IGF1 and should I combine them ?

      I've been asked more then several times if IGF1 should be combined with GH, and why not to take it by itself or instead of GH usage ?

      In a nutshell the ideal solution is using GH in combination with IGF1-lr3 and/or IGF1-DES

      It's true that the IGF1 is the mediator for most of the anabolic effect of the GH, but we must consider 2 things -

      1. The GH has some direct metabolic effect by itself, both in releasing glucose and fatty acid into the circulation, and by this raising metabolism and releasing available energy for anabolic demands, The GH has also a direct effect on nitrogen balance not through the IGF1 path
      2. The IGF1 itself has a direct suppressing effect on the endogenous GH release - so if u inject exogenous IGF you actually and directly suppress any GH present in the circulation

      So the ideal solution is combining them both and by this keep optimal serum GH and IGF1 levels

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      I'm very curious to see what people have to say about this

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      bump curious also right now im combining them but curious what is the best way to run these together
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      I have an idea so when you inject hgh after a said amount of time it converts and you release igf1 now I feel like if at that time you inject the igf1 the spike will be greater. I'm also running slin one hour after my hgh injections to help prolong the igf1 spike and help with blood sugar from the effects of hgh has on your insulin. I just don't know how long after your hgh injection igf1 levels start to spike. If anyone has any advice or knows a good protocol please share. This ifnjectnsulinntake so just a theory I have about timing.
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      Quote Originally Posted by stephen220 View Post
      I have an idea so when you inject hgh after a said amount of time it converts and you release igf1 now I feel like if at that time you inject the igf1 the spike will be greater. I'm also running slin one hour after my hgh injections to help prolong the igf1 spike and help with blood sugar from the effects of hgh has on your insulin. I just don't know how long after your hgh injection igf1 levels start to spike. If anyone has any advice or knows a good protocol please share. This ifnjectnsulinntake so just a theory I have about timing.
      I can tell you how I do it but I don't know if it's right bro. First of all I pin the long-form igf. I pin my gh as soon as I wake up. Then about an hour and a half later I pin my igf lr3 along with 65 grams of complex carbs and head off to the gym

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      so read how IGF-3 works and howand from what its made in your body and where and you wont ask this question

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      do what?
      Quote Originally Posted by yesidont View Post
      so read how IGF-3 works and howand from what its made in your body and where and you wont ask this question

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      What do you mean?

      Quote Originally Posted by yesidont View Post
      so read how IGF-3 works and howand from what its made in your body and where and you wont ask this question
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      I think what he asked is how and what is the lr3 molecule effect in the body ...

      The lr3 interacts and activates the receptor exactly as the endogenous IGF1, simply its pharmacokinetics are different, meaning the endogenous IGF1 travels merely short time in the serum and is deactivated by serum binding proteins while the lr3 has much longer half life (about 24 hours)

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      Been wondering this same thing myself,and looking for a solid answer recently.
      Purchased some igf but I haven't ran it yet for this reason of uncertainty.

      I heard before that the growth is run morning and day,and the igf to be used before bedtime to help boost the natty growth production but wasn't sure if this was correct info to use or not.
      So I keep it aside and just use the growth for now.


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