Thread: Ipamorelin Information

Ipamorelin is a fascinating new muscle building discovery that is
getting a lot of attention in the bodybuilding world. Like the GHRP-6
peptide (growth hormone releasing hexapeptide), it is a synthetic
peptide that has powerful Growth Hormone releasing properties. And
these GH releasing properties are what is of interest to athletes and
bodybuilders since they can make a tremendous difference in the amount
of muscle you can grow and how quickly you burn fat. Both Ipamorelin
and GHRP-6 as well as numerous other peptides and research chemicals
can be found at PurchasePeptides.com.


Whereas GHRP-6 is a hexapeptide, Ipamorelin is a penta-peptide.
(Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may
very well make regular old Growth Hormone (GH) obsolete. But what
athletes and bodybuilders really want to know is what is this wonder
peptide capable of doing, how is it used, and how does it compare to
the other GHRP peptides?


Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or
three times daily, using a tiny insulin needle to inject. They usually
start with the lower dose since side effects can include headaches or
what feels like a head-rush. Ipamorelin can be taken at anytime but
taking it about 30-45 minutes before a workout would seem ideal
because of the pulse in Growth Hormone (GH) it creates allowing for
maximum growth.


Studies on the effects of Ipamorelin on bone growth, body weight, and
GH release showed some interesting conclusions.


In one experiment, various doses were administered over the course of
15 days to test the group's reactions.


There was a distinct and dose-dependent effect on body weight gain
however, the treatment group did not show a change in total IGF-I
levels. Nor did the treatment group produce serum markers of bone
development. For example, the number of cells in the wide portion of
the tibia (the shinbone) did not change significantly. This is a good
thing because it suggests muscle growth with less potential for
deformity of bone or cartilage.


The reaction of the pituitary to an aggressive i.v. dose of Ipamorelin
showed that plasma GH levels were notably reduced whereas they were
unchanged after a comparable dose of GHRH. This is actually a good
thing as it suggests that Ipamorelin may not decrease your body's
natural GH production - further demonstrating that Ipamorelin is a
selective GH releaser.


Unlike GHRP-6, Ipamorelin does not induce hunger making it
advantageous to those on a restricted calorie diet. And obviously,
Ipamorelin's side-effects are enhanced when combined with anabolic
steroids since they too influence Growth Hormone/Insulin Growth Factor
release and production.


In another study in rats, Ipamorelin released GH from rat pituitary
cells as effectively as GHRP-6.


Another document states that in healthy swine, Ipamorelin released GH
with a consistency that is very comparable to GHRP-6. Also noteworthy
was that none of the GH releasers tested affected FSH, LH, PRL or TSH
blood serum plasma levels.


Ipamorelin in theory may increase Acetylchloine or Cortisol when used
in higher dosages. However, and increase in Acetylchloine or Cortisol
is even more likely with GHRP-2 and GHRP-6. In fact, in the case of
Ipamorelin, there was little to no rise in Acetylcholine and Cortisol
blood plasma levels even at injections more than 200 times higher than
the effective dosage for comparable GH release.


This clearly proves that Ipamorelin is the first successful GHRP
receptor agonist or chemical that binds to a receptor of a cell and
triggers a response by that cell with a specific selectivity for the
promotion of GH release by itself.


Another advantage to Ipamorelin is that it doesn't cause sudden spikes
in prolactin or cortisol as does GHRP-2 and GHRP-6. Ipamorelin is
slower in its delivery unlike GHRP's which spike GH levels at a more
rapid rate. The slower release is more natural and has a more
sustained effect.
( information gathered via internet )