Within your article, you state that each vial ought to have a vacuum in it.......well, a very very credible member of this board once stated a vacuum is not necessary....I wonder if the state of knowledge has changed over the last 3 years....about the time this individual made that remark....Overall, a very informative article and goes to show that things are more complicated than I realized....for starters, every Chinese province has its own GMP requirements, and a Hygetropin vial must have only 8ius per vial for it to be verified.