Thread: ALL ABOUT IGF-1 AND MORE!!

IGF-1 {insulin-like growth factor-1}

The Insulin-like Growth Factor is one of the endocrine hormones that is produced in the liver. The release of this hormone increases in the presence of Human Growth Hormone.*Numerous cells throughout the muscles of the human body are equipped with cell receptors that have a high affinity for Insulin-like Growth Factor. This makes this hormone one of the best growth hormones and a facilitator of general cell growth which it does by targeting different specific tissues and in more autocrine cell communication processes, it facilitates cell division.

Some Benefits of the Insulin-like Growth Factor 1 and some of the reasons why it has substantial advantages include:
* It facilitates protein synthesis in the body.
* It regulates the storage of fat and channels it to be used for the production of energy. This results in a noticeable fat loss.
* Promotes positive effects on metabolism; increasing lean body mass and decreases fat
* It increases the regenerative properties of the body’s nerve tissues.
* Upregulates anti-oxidant benefit and ligament strength
* It boosts hyperplasia in muscle cells, which leads to fuller muscle tissues.
* Optimal IGF-1 and growth hormone levels are crucial to bone development during childhood and throughout adult life.*

Why Would You Use IGF-1?
In simple terms, the weight gain that you will experience from the use of IGF-1 is not due to water weight. All your weight gain will be caused by actual muscle growth which is a long-term effect. Compared to steroids which are overly known for putting on water weight and often leading to adverse side effects, you will not get 10lbs from Insulin-like Growth Factors, but you will acquire*solid muscle gain*after every one or two weeks which will be composed of actual heavy muscle.
The most important feature of IGF-1 is its ability to cause hyperplasia in the human body. The body of a person who is on steroids goes through hypertrophy, this means that they will only be increasing the size of the existing cells in their muscles. On the other hand, IGF-1 leads to hyperplasia which purports the growth and development of new cells in the muscles. Generally, you will accomplish much more in terms of muscle density and size at a normal genetic level.
Variants of IGF-1
There are two groups of IGF variants. These are*IGF-1*LR3 and DES IGF-1 (which can also be presented as IGF-1 DES). The half-life of IGF-1 is very short, and because of this, it is quickly destroyed by the body. This is the main reason why IGF-1 was modified to produce an amino acid analog IGF-1 LR3 which has a longer half-life. The other variant of IGF-1, DES IGF-1 is a truncated version of IGF-1 which is up to ten times more potent than IGF-1. Both of these IGF-1 variants are similar to IGF-1 but they have different modes of action. This feature allows them to function together in different and specific ways.
IGF-1 LR3
The half-life of IGF-1 LR3 is about 20 – 30 hours. It is more potent than the regular base IGF-1. Because it can be sustained in the body for more than a day, it efficiently binds to cell receptors in the muscle cells and activates cell communication which subsequently improves the growth rate of muscles all day long.
IGF-1 LR3 inhibits the movement of glucose into the body cells which facilitates fat burning and the use of fat in the body for the production of energy. Its long life of close to a day has made it a preferred variant by a majority of patients and physicians because site injections are never necessary. IGF-1 LR3 cycles the whole body and binds to the receptors on muscle cells then acts for about a day, so a daily administration of this dosage is strongly supported.
IGF-1 DES
DES IGF-1 is a shorter version of the base IGF-1 chain. This variant of IGF-1 is five times more potent than the regular base IGF-1. It has a half-life of about twenty to thirty minutes which indicates that it is a very delicate chain. The administration of DES IGF-1 should only be done exactly where you want to experience muscle growth. DES IGF-1 has a higher ability to stimulate hyperplasia in the muscles than IGF-1 LR3. In conclusion, this variant works best when used for site injections and not overall muscle growth.
In addition to these functions, DES IGF-1 is known to bind to receptors, in cells, that have been deformed by lactic acid. Lactic acid is produced in elevated amounts during training and vigorous activities. This characteristic of DES IGF-1 allows it to attach to mutated receptors which signal tissue growth even during training activities. DES can be used more frequently and for a longer time than IGF-1 LR3.
IGF-1 Vs HGH
When we check on facts, the growth hormone is actually a precursor to the IGF-1, but why choose IGF-1 over the Growth Hormones? Growth Hormones do not cause direct muscle growth but instead, they facilitate the growth of muscles by signaling the release of the IGF-1. Human Growth Hormone can prove to be very difficult to qualify for. In order to have it be prescribed to you by a physician, you have to be diagnosed with Adult Growth Hormone Deficiency Syndrome. You must take and fail a Growth Hormone Stimulation Test which then indicates that your body is not producing growth hormone in response to a stimulus. This makes IGF-1 and its variants a much more viable solution for an athlete, someone losing to drop body fat or even those looking to get back into shape.
Protocols
IGF-1
This variant of IGF-1 should be taken daily for 7 days in a week. It’s best to take it after a workout. *Since IGF-1 has a very short half-life, desensitization will rarely be noticed.
IGF-1 LR3
This variant of IGF-1 should be taken daily for 7 days in a week. Desensitization occurs and protocol should not go beyond 90 days. A break is needed before resuming treatment. There are other treatment options during the break.*
DES IGF-1 (not available from*the ********)
DES IGF-1 should be dosed multiple times in a day, most preferably, before you embark on your training activities. You should target specific sites and muscles with this version. Since DES IGF-1 has a very short half-life, desensitization can rarely be noticed. You should always ensure that you localize your target sites so that you aim at specific muscle groups. If you want to enhance your biceps, you should administer this injection right into your biceps.

Max

So Max what do you prefer im just starting the igf1-lr3 @100 mcg immediately following a workout irs been 4 days already gained 3pd

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Thank you Max


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Originally Posted by Big Joe

So Max what do you prefer im just starting the igf1-lr3 @100 mcg immediately following a workout irs been 4 days already gained 3pd

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LR3 has such a long half life, I would imagine that same time each day would be the most important factor. Obviously there are other factors w slin, gh, PED’s. Sounds like you got it going. No longer than 40 days has seemed to be longest use before ineffective. Some start @ 40mcg and go up to 140mcg. Kinda a guess game depending on person. 100mcg is a good dose.

Max

Originally Posted by Mr.Beefy

Thank you..very informative. Questions...could suppression happen while on IGF-1LR3 or just desentizeation?

It is a tricky question. Suppression happens when using exogenous hormones/peptides. But you definitely get desensitized after a short time. I do not know how long normal igf1 output would take after. Sometimes, like testosterone it never comes back normally. This would take a lot more human trials and research; most would have been done on Turners Syndrome patients and en vivo/en vitro w Igf1 . I do know most of the Lr3 research has been done Eli Lilly and Merck smaller subsidiaries. Gotta rely on. Bodybuilders to record and post up most the results. That is very hard to do with all the restrictions/laws.

Max

Originally Posted by maxmuscle1

It is a tricky question. Suppression happens when using exogenous hormones/peptides. But you definitely get desensitized after a short time. I do not know how long normal igf1 output would take after. Sometimes, like testosterone it never comes back normally. This would take a lot more human trials and research; most would have been done on Turners Syndrome patients and en vivo/en vitro w Igf1 . I do know most of the Lr3 research has been done Eli Lilly and Merck smaller subsidiaries. Gotta rely on. Bodybuilders to record and post up most the results. That is very hard to do with all the restrictions/laws.

Max

Thank you, Max.

IMPORTANT IGF1 TESTING INFORMATION:
Sample of physician igf1 chart

{Sample of a US physician IGF-1 chart by age, some charts very a bit}

I was talking to my anti aging physician and as far as IGF-1 goes, he said the following:
YOU DO NEED to establish a real baseline no matter what!

He said that it is NOT about the igf1 number at all, in fact he said it really is just a gauge. He said that : THE INCREASE IN PERCENTAGE %, from your personal baseline is the MOST important factor as far as ; if you are getting results or not.

Example: your baseline is 150. After taking 4ius rHGH for 6 weeks and you test again and it is 225; you increased your igf-1 by 50%!! So some guys have naturally low Igf1 and think that going from 50 to 75 means it is bunk! That simply is not true, that person did in fact increase his own igf1 by 50%. A lot more important as far as your personal growth/results.

A 390 igf1 score doesn’t mean anything if your baseline was 363. Less than 10% increase! Just saying...

Max

**This has nothing to do with purity testing protocols. It is for your personal knowledge and to learn if you are or are not having results from your training/supp/diet. A baseline can be established natty, TRT. Whatever is normal for you. Then when you start your gh, you get to your same daily dose for 6 weeks and check again. The reason everything else needs to stay the same: especially if done on Cycle; diet, training, environment, supplements, drugs, health history and any medications can alter that score. So basically, make sure you are not changing your diet or cycle during the time you want to test. This is just for igf1, not gh serum!!

Max