GHK-Cu Peptide BENEFITS/INFO !!!

[maxmuscle1]

GHK-Cu Peptide BENEFITS/INFO !!!

What the heck copper-tripeptide-1 is, or GHK-Cu? The GHK part is a three amino acid peptide*of glycine-histidine-lysine that can be found naturally in yucky bodily fluids (if you are wondering in plasma, saliva, and urine). The Cu part is the copper, an essential trace element in the human body (and in all living things). It turns out GHK and Cu love each other, and if they meet, they form a complex that is called copper-tripeptide.*

Benefits Proven:
*GHK-Cu is a copper-peptide complex found naturally in yucky bodily fluids (plasma, saliva, and urine)
*It has unique wound healing properties by stimulating the breakdown of unhealthy, too large collagen in scar tissue and stimulating nice and healthy collagen production afterwards
*It stimulates the production of several important skin-identical ingredients (e.g. collagen, elastin, and glycosaminoglycans)
*It has significant anti-inflammatory and antioxidant effect


Wound healing and anti-inflammatory properties
The guy who discovered*GHK-Cu is called Dr. Pickart and in the first 15 years of his*GHK-Cu studies, he found out that it helps wound healing and has anti-inflammatory properties. His work resulted in the FDA-approved Iamin*hydrating gel to treat acute and chronic wounds.*
Helping wound healing does not seem like a big deal. If you read around INCIDecoder you can read the same about plenty of other ingredients, but GHK-Cu does have a special feature; it can stimulate the breakdown of unhealthy, too large collagen in scar tissue and can help stimulate nice and healthy normal collagen production. *And less bad collagen and more good collagen results in smoother, nicer skin.*

Helps good collagen production
Helping collagen production is a big deal in anti-aging skincare and there are very few ingredients that are really proven to do so. Copper-tripeptide is only half-way proven at this point but there are definitely promising results about it. Dr. Pickart himself made a successful in-vitro (made in test tubes, not on real people) study in 1988 showing that CHK-Cu can stimulate collagen synthesis.
There is an even more promising study from 1998 that was done on people and compared vitamin C, tretinoin, and copper-tripeptide. Do you know which one won? Copper tripeptide. After one month, it increased collagen production in 70% of people, while vitamin C only in 50% and tretinoin only in 40%.*

More anti-aging magic properties
If the above isn't enough, there is more. GHK-Cu seems to have a complex role in skin health*and tissue repair. It does not only help collagen synthesis but also the synthesis of other important skin-identical ingredients like elastin, proteoglycans, and glycosaminoglycans. It also has an*antioxidant effect by stimulating the antioxidant enzyme superoxide dismutase and preventing the release of oxidation-promoting iron.*
There are also a couple of facial studies showing that GHK-Cu containing creams can do pretty much everything you need for younger looking skin. It can tighten loose skin and improve elasticity, density, and firmness. It can reduce fine lines as well as deeper wrinkles. It can improve skin clarity and even reduce hyperpigmentation.*

Improving Hair Growth
While studying the wound healing properties of GHK-Cu, Dr. Pickart also noticed*that*after treating skin wounds*there was an enlargement of the hair follicles of the skin at the wound edge. This led him to discover that skin remodelling copper peptides (SRCPs) can also stimulate hair growth. It works by stimulating follicular cell proliferation that results in larger hair follicles that produce longer and thicker hair. *SRCPs also keep*the hair follicles longer in the active, anagen phase and shorter in the inactive, dormant phase.

So what's the catch?
Well, most studies done on copper-tripeptide are in-vitro (meaning in the lab and not on real people) or on animals. Results may or may not be the same on us, people. There are some facial studies that are promising, but they are quite small and not designed to the strictest standards (by which we mean double blind, placebo controlled.)
Another catch is that when it comes to facial anti-aging skin care stimulating hair growth is not really a good thing (unless of course, more facial hair is ok for you). Dr. Pickart himself tells this about the issue: *"The SRCPs increase the size of hair follicles but do not convert the small vellus hair follicles that produce fine, nearly invisible hair (98% of body hair) into terminal follicles (2% of body hair) that produce thick, long hair. The enlarged hair follicles produce the stem cells needed to rebuild skin.*Many women have used our facial products for 5 years without problems." Reading around on skincare forums, some did see slightly more facial hair*some not. This is again something that you have to try and see.
Last but not least there is an "urban legend" about the possibility to overdose on copper peptide resulting not in younger but older looking skin. We could not find any study or research paper about this but Dr Todorov said on Today Show interview, "..excessive use can have an opposite effect by increasing the levels of free copper and/or by triggering excessive production of metalloproteinases. Free copper promotes free radical damage and collagen breakdown leading to accelerated skin aging. Metalloproteinases can digest collagen and elastin, weakening the skin and causing sag. These problems do not seem to occur among the majority of copper peptide users. However, there are anecdotal reports indicating that such side-effects might happen with overuse, incorrect use, or even normal use in sensitive individuals. Ideally, a sufficiently large study is needed to better quantify these risk."
There you have it! If you are still here, congrats, you just became a GHK-Cu expert. It is definitely a very interesting and promising ingredient, so if you are into anti-aging and like to experiment this is something for you.

Show me some proof
References:
* BioMed Research International, Volume 2015 – Jan 1, 2015, GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
* Loren R. Pickart, Use of GHL-Cu as a wound-healing and anti-inflammatory agent, Patent US 4760051 A
* FEBS Lett. 1988 Oct 10;238(2):343-6., Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+
* Disease Management and Clinical Outcomes 1(4):136-141 · July 1998, Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study
* Arch ***** Res. 2007 Jul;30(7):834-9., The effect of tripeptide-copper complex on human hair growth in vitro.
* Cosmetics & Medicine (Russia) July 2004, Loren Pickart PhD, Improving Hair Growth with Skin Remodeling Copper Peptides

Hope this answers some questions you may have about the peptide - GHK-Cu
Max

[maxmuscle1]

CONTINUED:

GHK-Cu has cortisol blocking abilities:
GHK-Cu, administered systemically to mice, rats, and pigs, has protective effects on cortisone—induced inhibition of wound healing

GHK has potent anti-pain, anti-anxiety (anxiolytic) and anti-aggression actions:

Anti-pain effects were measured by determining how long it took for mice to lick their paws after being placed on a mildly-hot plate. Here, GHK reduced pain at a dose of 0.5 milligrams/kilogram. GHK has a physical structure similar to cimetidine which is often used to reduce pain in humans [51,52].
The anti-anxiety, anti-pain and anti-aggression actions were found in rats. When rats are afraid, they try to hide. But within 12 min of intraperitoneal injection of GHK at 0.5 micrograms/kilogram into rats in a testing cage built as a maze, the amount of time the rats spent exploring more open and lighted areas of the maze increased, and the time spent immobile (the freeze reaction) decreased, which indicated a reduction of fear and anxiety [53]. The same occurred in a test “open field”, where the rats spent less time hiding and more time exploring the area .
Likewise, the anti-aggression actions were found in rats. For the experiment, two rats are placed in a small cage and then given small electrical shocks, which produces anger in the rats and led to physical attacks on the other rat. The attacks were reduced 5-fold, when rats were placed into an agression-stimulating environment 12 min after the injection of 0.5 micrograms GHK per kilogram of body weight. If scaled up for human weight, this suggests that a similar effect might be induced in humans by 35 micrograms of GHK, which is a very low and safe dosage.

GHK-Cu applied to thigh skin for 12 weeks improved collagen production in 70% of the women treated, in contrast to 50% treated with the vitamin C cream, and 40% treated with retinoic acid [16]. In addition to improving skin laxity, clarity, firmness and appearance, reducing fine lines, coarse wrinkles and mottled pigmentation, and increasing skin density and thickness, GHK-Cu cream applied twice daily for 12 weeks also strongly stimulated dermal keratinocyte proliferation.

Max

[BarbellNinja]

I used this on my face twice a day for 2 months and saw zero anti-aging benefits. I get way more out of Retinol. I'm fairly certain it was from a legit source. It was also very expensive.

Maybe I needed to stick with it longer.....but not worth the $$ for what I saw.

[maxmuscle1]

I used this on my face twice a day for 2 months and saw zero anti-aging benefits. I get way more out of Retinol. I'm fairly certain it was from a legit source. It was also very expensive.

Maybe I needed to stick with it longer.....but not worth the $$ for what I saw.

Yeah. There are literally thousands of beauty products made that dont really work. My girl deals with the big companies .
I am interested because of many reasons: one is the anti inflammatory properties . It in its raw form is a super blue powder.
Ghk-Cu , Retinol, 15-20% vit C all seem to have great effects. Problem is- the companies only put tiny amounts. I know 15% C serum works phenomenal for face as I use Sunday Riley. Just after shower and Luna {blue tansy oil} before bed. I am looking at the injectables studies and IV products used at Spas . Just research but, possibly Gluthianone and GHK-Cu could help as a really good oral and inj supplement. The facial lightening products all have Gluthianone{also called TAD-5000)

Max
#shareinfo