Thread: (Ora-Sweet) The Simple way to turn your oral raws into liquids!!!

I believe you need to account for powder displacement, otherwise your solution will be underdosed.
Mixing 1 gram of powder with 100ml will not yield 10mg/ml. This is because after adding 100ml of fluid, the powder will displace the fluid bringing total fluid level above 100ml.
Lets say I need to make 30ml of an oral solution that is 5mg/ml. So basically 30 doses @ 5mg. 30x5=150mg total powder needed.
Now, let's say I have a beaker with the 150mg powder in it. I then add the 30ml of carriers. Well, now I have a liquid that is above the 30ml mark, because of the displacement of powder. This would mess up our original mg/ml.
Now a simple solution is to put powder in small beaker, then fill with some suspension liquid, stir a little bit, add some more, stir a little more, then pour suspension liquid until it reaches the 30ml mark.
A good small beaker with accurate markings, could work.

"Beaker Accuracy Check": If you don't trust the accuracy of the beaker, you can fill a 30ml syringe with fluid and administer to beaker varying amounts to see if it corresponds/correlates to the same amount on beaker.

Syringe Acting as Graduated Cylinder and Shaker:
Another accurate method would be to get a 30ml or 60ml syringe, put small needle on end of syringe. We are merely just capping off the syringe so that no fluid will come out of the syringe when we add liquid (backfill) the syringe. For safety, of course, you would want to leave the cap on the needle. Remove plunger from syringe, hold syringe upright, and add some suspension liquid into syringe, and add all 150mg of powder. Now, we need to put the plunger back into the syringe so we can shake the syringe to mix. You would put plunger in syringe just a little to seal, then turn syringe over, so the air is at the needle end. Then push plunger into syringe. (The problem here is that you can still lose some fluid through the needle, that may have remained in the hub of the needle. Very negligible amount, but something to consider) Now, shake syringe, mixing powder and suspension liquid in syringe, then remove plunger and fill with more suspension fluid until it reaches 30ml mark, shake some more, and finally check to ensure that the total liquid is still at the 30ml mark.

Displacement per dose:
You could also find displacement per dose per ml by putting 1ml suspension fluid in syringe, add 5mg powder, mix, and see where the fluid mixture is at. Then note the difference. There really is no reason to do this. Maybe for your own records when using the same raw to make varying mixtures.

Very accurate measuring balances/scale devices are pretty pricey. Small measurements like this require that you follow special protocol to ensure accuracy. Actually, with all these measurements, a more expensive and accurate scale with plastic or glass hood/cover would be nice.

Correct me if wrong.

Made 30ml cialis @10mg/ml using syringe for measuring and shaking. Used Ora-Plus.
I think some compounds may require a solvent. Cialis is a fine sticky powder and can clump easily. I can see some very very small clumps even the next day. Placed in hot water bath to warm mixture, shook more for about 5 minutes, still very small clumps.
I don't think I would suspend something like prami in this.
I will most likely use grain alcohol or search for a pharmaceutical solvent.
The process was remove stopper, place plug in needle end of syringe. I cut an unused earplug, rolled the small piece between my fingers, and placed it in the small hole to plug.
I then added around 12ml distilled water to syringe, then 300mg powder, swirled it around, then filled to 30ml line.
I put finger over needle end hole, and put plunger back in but did not push it in, just put the plunger in until it seated in syringe. I then flipped it over with plugged needle end up so air would go to top. I then removed plug, then pushed plunger to 50ml line to leave some space for shaking. I then just put my finger over needle end hole, and shook vigorously for a while. Once mixed, squirted into bottle. There was a very small amount stuck to stopper, so drew in a couple drops of distilled water, shook, squirted into bottle.
Now, I have a milligram scale with plastic hood. I also have some micro milligram spoons I got off amazon. I have one that measured 10mg out of 5 measurement tests. I could just use that. However, suspension is much more convenient.

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Originally Posted by Skippy

Shit I was wanting to try the Ora sweet with prami till I read this. Did you mix any Prami ? Im trying not to use alcohol just wondering what you used.

Use distilled water for prami. You need a mg scale with plastic hood. I mix 30mg in 30ml distilled water using Class A graduated cylinder. No need for displacement with such small amount. BE CAREFUL. DO NOT SCREW UP MEASUREMENT.
Just know studies have been done and one patient took 12mg of Prami. DON'T TRY THAT. I am merely showing that you won't die from a small microgram deviation by not accounting for displacement of such small amount.

Make sure you research the solubility of the substance you wish to suspend. Do not use brand names when researching, but actual drug name. For Cialis, use Tadalafil
Example: Google search Tadalafil Solubility
You will be presented with various things, but you are looking for studies, .pdf's, and patents.

Screenshot_2018-02-23-20-18-32.png

Within patents are basically blueprints of the inventions. You have to scroll through repetitive info, to get to the good stuff. Read through this patent and notice the structure of the patent. You get to a "Detailed" portion further down.
WO21422797A1 - Pharmaceutical composition comprising a solid dispersion of tadalafil
- Google Patents


Some are pdf's
This one has a ton of info on Tadalafil.
https://www.google.com/url?sa=t&sour...PmUxKyrUWuF26x

Learn as much as you can about the substance, and you will also learn advanced methods of preparation and exact equipment used.

Also search for info on the FDA and EMEA home sites.