Post Cycle Therapy




Goals of post cycle therapy: Stimulation of the HPTA (Hypothalamic Pituitary Testicular Axis)

SERMs (Selective Estrogen Receptor Modulators) - Block estrogen from acting on tissue.

Nolvadex (tamoxifen citrate)
10mg tablets = 15.2mg of tamoxifen citrate which is equivalent to 10mg of tamoxifen.

20mg tablets = 30.4mg of tamoxifen citrate which is equivalent to 20mg of tamoxifen.

Raloxifene - Raloxifene is a selective estrogen receptor modulator that produces both estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue.

Clomiphene Citrate (Clomid, Serophene) - Clomid is capable of reacting with all of the tissues in the body that have estrogen receptors. It influences the way that the four hormones GnRH, FSH, LH and estradiol, relate and interrelate. It appears that Clomid fools the body into believing that the estrogen level is low. This altered feedback information causes the hypothalamus to make and release more gonadotropin releasing hormone (GnRH) which in turn causes the pituitary to make and release more FSH and LH. More follicle stimulating hormone and more luteinizing hormone should result in increased testosterone production.

Droloxifine (experimental)

Idoxifene (experimental)

Toremifene Citrate (experimental) - Less toxic than tamoxifen citrate and better on lipids and bone density. Discussions: 1 2

AIs (Aromatase Inhibitors): Aromatase is the enzyme that causes the conversion of testosterone into estradiol and androstenedione into estrone. Aromatase inhibitors lower the amount of estrogen in post-menopausal women who have hormone-receptor-positive breast cancer. The hormone estrogen delivers growth signals to the hormone receptors. With less estrogen in the body, the hormone receptors receive fewer growth signals, and cancer growth can be slowed down or stopped.

6-OXO (chemical name: 3,6,17-androstenetrione) - A suicide inhibitor of aromatase. Binds to the aromatase enzyme in a permanent and irreversible manner, rendering it inactive. The result of this is an eventual diminishment of aromatase enzyme in the body and a concomitant reduction in estrogen levels. A corresponding increase in testosterone production is usually experienced as well.

Arimidex (chemical name: anastrozole) - Type 2 "non-steroidal inhibitors." They also stop the activity of the aromatase enzyme, but not permanently.

Letrozole (Femara) - An oral, anti-estrogen drug used for treating postmenopausal women with breast cancer. Letrozole prohibits the enzyme in the adrenal glands (aromatase) that produces the estrogens, estradiol and estrone. Can be taken with or without food.
Aromasin (chemical name: exemestane) - Type 1 "steroidal inhibitor," which stops the activity of the aromatase enzyme forever.
Chrysin - Chrysin is a flavonoid that has been purported especially in the bodybuilding world to be an effective inhibitor of an enzyme known as aromatase. European Olympic athletes report 1-3 grams of chrysin per day is a safe and effective dose. Chrysin may have poor bioavailability. Discuss
Ester C (Vitamin C) - Has some natural Aromatase Inhibiting properties. 2-4 grams of Ester C per day should be safe.

ATD (1,4,6-androstatriene-3,17-dione): Stops estrogen production?
Rebound XT - Can be run inversely to a SERM. This is best when hCG is included. As the SERM dose goes down and hCG is phased out over a few wks, the Rebound XT goes up. I've posted everywhere on this method. Also, Rebound XT can be used solo for uncomplicated PCTs when stacked with DHEA and Fenugreek for short, oral only cycles (1 month or less). Last, Rebound XT can be used at the very end of a PCT just to taper off of SERMs. I haven't tried it yet, but it makes sense for longer PCTs or when an edge on test production or reduced estrogen is desired long term.


Ultra H.O.T.
Ultra H.O.T.ter
Anastrazole
Letrozole
Novedex XT

Discussion on running SERM inverse to ATD
Estrogen only "rebounds" based on the mechanism of suppression. SERM, for example, only masks estrogen expression by occupying receptors but estrogen production is left unchecked and actually increases as testosterone levels increase. AI's like letro inhibit inducible enzymes and just like a leaky faucet, they body will eventually try to balance the equation with increased aromatase activity. Steroidal AI's like Teslac, Exemestane, and ReboundXT will not result in 'rebound' phenomena because the inhibition is non-competitive and irreversible. They act as false substrates, so aromatase is still happy to act on them (instead of androstenedione) and the body keeps no record of an imbalance. There is no leaky faucet. In fact, after prolonged use, steroidal AI's often produce a protracted anti-e benefit even after being discontinued. This is why I suggest an inverse taper with SERM and RXT for PCT with an abrupt stoppage of RXT at the end. As the SERM elevates androgen/estrogen production, the AI dose is increased to compensate while the SERM is phased out. It works quite well to use this approach and rebound is not encountered. Adding LX and/or DHEA also really makes for a killer PCT in this scheme.


This is a typical example of my PCT:

***Post-Cycle Therapy:
__________________________________________________ ____________________________________
Start this protocol two weeks after your last injection of an Enanthate/Cypionate/Undecylenate product, or one day after your last injection of a short-ester product (Acetate, Propionate, Phenylpropionate, etc) at the end of your cycle.

Optional at the beginning: HCG at 1000iu for 3 days to quickly re-start your testicular function
Week 1: Nolvadex 40mg per day, Clomid 50-75mg per day
Week 2: Nolvadex 40mg per day, Clomid 50mg per day
Week 3: Nolvadex 20mg per day, Clomid 50mg per day
Week 4: Nolvadex 20mg per day, Clomid 25mg per day

***Gynecomastia: Use Letrozole at 2mg per day will quickly stop it. Tamoxifen (Nolvadex) is also helpful with this.




The list below determines when you should start Clomid. Select from the list any steroids you've used in your cycle and whichever one has the latest starting point is the time to commence Clomid. For example, if Dianabol, Sustanon and Winstrol were cycled, the time for administering Clomid should be 3 weeks post cycle, as Sustanon remains active in the body for the longest period of time. Read the discussion here.



Steroid...............Time after last administration.........Length of clomid cycle
Anadrol50/Anapolan50........8 - 12 hours.............................3 weeks
Deca durabolan.................3 weeks...................................4 weeks
Dianabol...........................4 - 8 hours...............................3 weeks
Equipoise.........................17 - 21 days..............................3 weeks
Finajet/Trenbolone..............3 days....................................3 weeks
Primabolan depot................10 - 14 days............................2 weeks
Sustanon.............................3 weeks................................3 weeks
Testosterone Cypionate..........2 weeks................................3 weeks
Testosterone Enanthate/Testaviron...2 weeks.......................3 weeks
Testosterone Propionate.........3 days..................................3 weeks
Testosterone Suspension.........4 - 8 hours...........................2-3 weeks
Winstrol.................................8 - 12 hours........................2-3 weeks

Other products to help increase natural testosterone or aid workouts during PCT:

Tribulus, Fenugreek, Forskolin, DHEA, Rebound XT, Rebound Reloaded, Reduce XT, ActivaTe, Anabolic Xtreme PCT, Retain (reduce cortisol), Lean Extreme (reduce cortisol), CEE (Creatine Ethyl Ester). Nitric Oxide (NO2), Ultra H.O.T., Ultra HOTTER

Activate - Should be used starting the last wk or 2 wks of a cycle and continued for no longer than 8 total weeks into PCT. 6 weeks seems perfect to me. The first and last week of dosing should consist of a half dose, and the weeks in between full doses. It's okay to take more than the full dose too because it's effects are non-toxic and dose dependent.


Products to help with blood pressure and cholesterol regulation / liver and support:


Liver: K-R-ALA, NAC ( N-Acetyl-Cysteine), Milk Thistle (80% standardized Silymarin), Lecithin


Cholesterol: Sesathin, Guggul, Red Yeast Rice*, CoEnzyme Q10*, Flax Seed Oil, Safflower Oil*, Policosanol*, Niacin, Garlic, Hawthorn Berry (helps regulate blood pressure as well), Pantethine

Blood Pressure: Hawthorne Berry, Coenzyme Q10, Garlic (best with high concentration of Allicin), Celery Seed Extract (best with high concentration of 3NB), C-12 Peptide. Also, high-dose vitamin B6 and vitamin C. High-dose vitamin D is also beneficial for Blood Pressure (not sure how, though).


Basic Post Cycle Therapy:

Clomid:
Day 1: 150mg
Day 2-11: 100mg daily
Day 12-21: 50mg daily


Clomid:
week 1: 150mg
week 2: 100
week 3: 50
week 4: 50


Tamoxifen:
Week 1 (or 2): 40-50 mg daily.
Week 2 (or 3) through week 4 (or 5): 20-25mg daily.


Heavy
Tamoxifen\Clomid Combo:
Week 1: 150 clomid\60 nolva
Week 2: 100 clomid\40 nolva
Week 3: 50 clomid\20 nolva
Week 4: 50 clomid\20 nolva

Or moderate



Week 1: 100 clomid\60 nolva
Week 2: 50 clomid\40 nolva
Week 3: 50 clomid\20 nolva
Week 4: 50 clomid\20 nolva


Simple
Clomiphene @ 75/50/50/50
Tamoxifen @ 40/20/20/20





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