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    Thread: Post Cycle Therapy (PCT)

    1. #1
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      Post Cycle Therapy (PCT)

      Post Cycle Therapy




      Goals of post cycle therapy: Stimulation of the HPTA (Hypothalamic Pituitary Testicular Axis)

      SERMs (Selective Estrogen Receptor Modulators) - Block estrogen from acting on tissue.

      Nolvadex (tamoxifen citrate)
      10mg tablets = 15.2mg of tamoxifen citrate which is equivalent to 10mg of tamoxifen.

      20mg tablets = 30.4mg of tamoxifen citrate which is equivalent to 20mg of tamoxifen.

      Raloxifene - Raloxifene is a selective estrogen receptor modulator that produces both estrogen-agonistic effects on bone and lipid metabolism and estrogen-antagonistic effects on uterine endometrium and breast tissue.

      Clomiphene Citrate (Clomid, Serophene) - Clomid is capable of reacting with all of the tissues in the body that have estrogen receptors. It influences the way that the four hormones GnRH, FSH, LH and estradiol, relate and interrelate. It appears that Clomid fools the body into believing that the estrogen level is low. This altered feedback information causes the hypothalamus to make and release more gonadotropin releasing hormone (GnRH) which in turn causes the pituitary to make and release more FSH and LH. More follicle stimulating hormone and more luteinizing hormone should result in increased testosterone production.

      Droloxifine (experimental)

      Idoxifene (experimental)

      Toremifene Citrate (experimental) - Less toxic than tamoxifen citrate and better on lipids and bone density. Discussions: 1 2

      AIs (Aromatase Inhibitors): Aromatase is the enzyme that causes the conversion of testosterone into estradiol and androstenedione into estrone. Aromatase inhibitors lower the amount of estrogen in post-menopausal women who have hormone-receptor-positive breast cancer. The hormone estrogen delivers growth signals to the hormone receptors. With less estrogen in the body, the hormone receptors receive fewer growth signals, and cancer growth can be slowed down or stopped.

      6-OXO (chemical name: 3,6,17-androstenetrione) - A suicide inhibitor of aromatase. Binds to the aromatase enzyme in a permanent and irreversible manner, rendering it inactive. The result of this is an eventual diminishment of aromatase enzyme in the body and a concomitant reduction in estrogen levels. A corresponding increase in testosterone production is usually experienced as well.

      Arimidex (chemical name: anastrozole) - Type 2 "non-steroidal inhibitors." They also stop the activity of the aromatase enzyme, but not permanently.

      Letrozole (Femara) - An oral, anti-estrogen drug used for treating postmenopausal women with breast cancer. Letrozole prohibits the enzyme in the adrenal glands (aromatase) that produces the estrogens, estradiol and estrone. Can be taken with or without food.
      Aromasin (chemical name: exemestane) - Type 1 "steroidal inhibitor," which stops the activity of the aromatase enzyme forever.
      Chrysin - Chrysin is a flavonoid that has been purported especially in the bodybuilding world to be an effective inhibitor of an enzyme known as aromatase. European Olympic athletes report 1-3 grams of chrysin per day is a safe and effective dose. Chrysin may have poor bioavailability. Discuss
      Ester C (Vitamin C) - Has some natural Aromatase Inhibiting properties. 2-4 grams of Ester C per day should be safe.

      ATD (1,4,6-androstatriene-3,17-dione): Stops estrogen production?
      Rebound XT - Can be run inversely to a SERM. This is best when hCG is included. As the SERM dose goes down and hCG is phased out over a few wks, the Rebound XT goes up. I've posted everywhere on this method. Also, Rebound XT can be used solo for uncomplicated PCTs when stacked with DHEA and Fenugreek for short, oral only cycles (1 month or less). Last, Rebound XT can be used at the very end of a PCT just to taper off of SERMs. I haven't tried it yet, but it makes sense for longer PCTs or when an edge on test production or reduced estrogen is desired long term.


      Ultra H.O.T.
      Ultra H.O.T.ter
      Anastrazole
      Letrozole
      Novedex XT

      Discussion on running SERM inverse to ATD
      Estrogen only "rebounds" based on the mechanism of suppression. SERM, for example, only masks estrogen expression by occupying receptors but estrogen production is left unchecked and actually increases as testosterone levels increase. AI's like letro inhibit inducible enzymes and just like a leaky faucet, they body will eventually try to balance the equation with increased aromatase activity. Steroidal AI's like Teslac, Exemestane, and ReboundXT will not result in 'rebound' phenomena because the inhibition is non-competitive and irreversible. They act as false substrates, so aromatase is still happy to act on them (instead of androstenedione) and the body keeps no record of an imbalance. There is no leaky faucet. In fact, after prolonged use, steroidal AI's often produce a protracted anti-e benefit even after being discontinued. This is why I suggest an inverse taper with SERM and RXT for PCT with an abrupt stoppage of RXT at the end. As the SERM elevates androgen/estrogen production, the AI dose is increased to compensate while the SERM is phased out. It works quite well to use this approach and rebound is not encountered. Adding LX and/or DHEA also really makes for a killer PCT in this scheme.


      This is a typical example of my PCT:

      ***Post-Cycle Therapy:
      __________________________________________________ ____________________________________
      Start this protocol two weeks after your last injection of an Enanthate/Cypionate/Undecylenate product, or one day after your last injection of a short-ester product (Acetate, Propionate, Phenylpropionate, etc) at the end of your cycle.

      Optional at the beginning: HCG at 1000iu for 3 days to quickly re-start your testicular function
      Week 1: Nolvadex 40mg per day, Clomid 50-75mg per day
      Week 2: Nolvadex 40mg per day, Clomid 50mg per day
      Week 3: Nolvadex 20mg per day, Clomid 50mg per day
      Week 4: Nolvadex 20mg per day, Clomid 25mg per day

      ***Gynecomastia: Use Letrozole at 2mg per day will quickly stop it. Tamoxifen (Nolvadex) is also helpful with this.




      The list below determines when you should start Clomid. Select from the list any steroids you've used in your cycle and whichever one has the latest starting point is the time to commence Clomid. For example, if Dianabol, Sustanon and Winstrol were cycled, the time for administering Clomid should be 3 weeks post cycle, as Sustanon remains active in the body for the longest period of time. Read the discussion here.



      Steroid...............Time after last administration.........Length of clomid cycle
      Anadrol50/Anapolan50........8 - 12 hours.............................3 weeks
      Deca durabolan.................3 weeks...................................4 weeks
      Dianabol...........................4 - 8 hours...............................3 weeks
      Equipoise.........................17 - 21 days..............................3 weeks
      Finajet/Trenbolone..............3 days....................................3 weeks
      Primabolan depot................10 - 14 days............................2 weeks
      Sustanon.............................3 weeks................................3 weeks
      Testosterone Cypionate..........2 weeks................................3 weeks
      Testosterone Enanthate/Testaviron...2 weeks.......................3 weeks
      Testosterone Propionate.........3 days..................................3 weeks
      Testosterone Suspension.........4 - 8 hours...........................2-3 weeks
      Winstrol.................................8 - 12 hours........................2-3 weeks


      Other products to help increase natural testosterone or aid workouts during PCT:

      Tribulus, Fenugreek, Forskolin, DHEA, Rebound XT, Rebound Reloaded, Reduce XT, ActivaTe, Anabolic Xtreme PCT, Retain (reduce cortisol), Lean Extreme (reduce cortisol), CEE (Creatine Ethyl Ester). Nitric Oxide (NO2), Ultra H.O.T., Ultra HOTTER

      Activate - Should be used starting the last wk or 2 wks of a cycle and continued for no longer than 8 total weeks into PCT. 6 weeks seems perfect to me. The first and last week of dosing should consist of a half dose, and the weeks in between full doses. It's okay to take more than the full dose too because it's effects are non-toxic and dose dependent.


      Products to help with blood pressure and cholesterol regulation / liver and support:


      Liver: K-R-ALA, NAC ( N-Acetyl-Cysteine), Milk Thistle (80% standardized Silymarin), Lecithin


      Cholesterol: Sesathin, Guggul, Red Yeast Rice*, CoEnzyme Q10*, Flax Seed Oil, Safflower Oil*, Policosanol*, Niacin, Garlic, Hawthorn Berry (helps regulate blood pressure as well), Pantethine

      Blood Pressure: Hawthorne Berry, Coenzyme Q10, Garlic (best with high concentration of Allicin), Celery Seed Extract (best with high concentration of 3NB), C-12 Peptide. Also, high-dose vitamin B6 and vitamin C. High-dose vitamin D is also beneficial for Blood Pressure (not sure how, though).


      Basic Post Cycle Therapy:

      Clomid:
      Day 1: 150mg
      Day 2-11: 100mg daily
      Day 12-21: 50mg daily


      Clomid:
      week 1: 150mg
      week 2: 100
      week 3: 50
      week 4: 50


      Tamoxifen:
      Week 1 (or 2): 40-50 mg daily.
      Week 2 (or 3) through week 4 (or 5): 20-25mg daily.


      Heavy
      Tamoxifen\Clomid Combo:
      Week 1: 150 clomid\60 nolva
      Week 2: 100 clomid\40 nolva
      Week 3: 50 clomid\20 nolva
      Week 4: 50 clomid\20 nolva

      Or moderate



      Week 1: 100 clomid\60 nolva
      Week 2: 50 clomid\40 nolva
      Week 3: 50 clomid\20 nolva
      Week 4: 50 clomid\20 nolva


      Simple
      Clomiphene @ 75/50/50/50
      Tamoxifen @ 40/20/20/20





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      This is some great information right here. It has everything you need to know and is a great reference.
      Last edited by Familyguy; 04-25-2012 at 09:35 PM.

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      Going to try the combo for my next PCT

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      Awesome information. Thanks Pain. This really helps me figure out my pct.
      If you heard the shot, you were'nt the target.

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      Hope this doesn't sound stupid but it's kinda been on my mind for awhile. "How do you know if chlomid is working?" are you supposed to feel something ?

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      Quote Originally Posted by 1tuffcookie View Post
      Hope this doesn't sound stupid but it's kinda been on my mind for awhile. "How do you know if chlomid is working?" are you supposed to feel something ?
      Some get symptoms, some don't. So, you may not be able to tell at all.
      Credentials:

      • Masters Degree in Exercise Physiology
      • Registered Clinical Exercise Physiologist (ACSM)
      • Certified Exercise Specialist (ACSM)



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      I always suggest using HCG towards the end of every cycle, last 2 weeks, and into the beginning of PCT. It makes recovery much smoother.

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      Quote Originally Posted by c_so19 View Post
      I always suggest using HCG towards the end of every cycle, last 2 weeks, and into the beginning of PCT. It makes recovery much smoother.
      Why not use it the entire cycle?
      Credentials:

      • Masters Degree in Exercise Physiology
      • Registered Clinical Exercise Physiologist (ACSM)
      • Certified Exercise Specialist (ACSM)



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      Yea I read a great article about some clinical reaserch done with HCG on bodybuilders. I can't give you all of the clinical jargan but I can say the study was conclusive that using HCG during your cycle is more effective at restoring your natural testi. action. then waiting to the end of a cycle. I will try to find the article and post. It really is very informative.

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      Quote Originally Posted by exphys88 View Post
      Some get symptoms, some don't. So, you may not be able to tell at all.
      What type of symptoms would I be looking for. I def. have been alittle more emotional lately, I know that's 1 effect, anymore??

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