There so much bad publicity I guess you would call it surrounding Accutane, but most of it is in the context of when it was rx'ed at 50+ mgs a day. Very little research actually exists on low dose , mid to long term use. I went as long as 6 months at 10mgs a day and had not one adverse effect other than dry lips and kind of dry bloody nose at the very first. Not much is said also about Accutanes ability to reverse damage and heal scars also. I think its one of those items you should always have on hand. Just my .02