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    Thread: Antidepressants affecting post/on cycle therap

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      Antidepressants affecting post/on cycle therap

      I have been reading a lot more into the affects antidepressants can have on your pct meds like nolvadex.
      Below is a chart of some meds and their affects with nolvadex.
      Antidepressant Drug Interaction with Tamoxifen Safety Range
      Paxil (paroxetine)
      Prozac (fluoxetine)
      Prevents antiestrogen benefit Avoid Use
      Cymbalta (duloxetine)
      Wellbutrin (bupropion)
      Zoloft (sertraline)
      Medium interference with antiestrogen benefitNote: Studies confirm that Zoloft interferes with Tamoxifen. Increases Risk
      Saint John's Wort
      (hypericum)
      Modest inhibition of antiestrogen benefit Increased Risk
      Celexa (citalopram)
      Lexapro (escitalopram)
      Pristiq (desvenlafaxine)
      Remeron (mirtazapine)
      Mild interactionNote: Pristiq and Remeron have not been well-studied for interaction with Tamoxifen. Slight Risk
      Black Cohosh
      (Actaea)
      May enhance the antiestrogen benefitNote: There are just a few studies for interaction with Tamoxifen. Slight Risk
      Effexor (venlafaxine) Almost no interaction with Tamoxifen Best Choice
      Sources:

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      Quote Originally Posted by Stronger123 View Post
      I have been reading a lot more into the affects antidepressants can have on your pct meds like nolvadex.
      Below is a chart of some meds and their affects with nolvadex.
      Antidepressant Drug Interaction with Tamoxifen Safety Range
      Paxil (paroxetine)
      Prozac (fluoxetine)
      Prevents antiestrogen benefit Avoid Use
      Cymbalta (duloxetine)
      Wellbutrin (bupropion)
      Zoloft (sertraline)
      Medium interference with antiestrogen benefitNote: Studies confirm that Zoloft interferes with Tamoxifen. Increases Risk
      Saint John's Wort
      (hypericum)
      Modest inhibition of antiestrogen benefit Increased Risk
      Celexa (citalopram)
      Lexapro (escitalopram)
      Pristiq (desvenlafaxine)
      Remeron (mirtazapine)
      Mild interactionNote: Pristiq and Remeron have not been well-studied for interaction with Tamoxifen. Slight Risk
      Black Cohosh
      (Actaea)
      May enhance the antiestrogen benefitNote: There are just a few studies for interaction with Tamoxifen. Slight Risk
      Effexor (venlafaxine) Almost no interaction with Tamoxifen Best Choice
      Sources:
      Great info, all toss an addition to this brother!
      Antidepressant Effects and Steroids


      Introduction

      Today’s world can be painstakingly stressful,People are in a rush to compete or get somewhere,with a self appointed deadline.. With this being said ,many people are turning to medication, as large phrama tends to peddle medication and dispense it down our throats (It seems that everyone now suffers from some sort of mental aliment)..There was a study performed in 2005 as it showed that 27 million Americans were taking antidepressants (This is just America alone), almost double by 2010, and steadily increased up until 2015 this represents roughly 25% of the population at this time, and this number has certainly expected to rise as studies show antidepressant usage has been on a continual increase. Unfortunately enough its been proven that usage continues to rise significantly among young/adult men.

      Let’s begin the discussion and what this article pertains to,and about is users taking antidepressants and how they affect anabolic steroid, post cycle therapy, testosterone levels and in general building muscle.
      This discussion has taken place on are numerous internet panels, thousands of questions/concerns regarding antidepressant usage and anabolic steroid cycles..
      To keep on point and avoid going off topic on the details about how these antidepressants effect depression and anxiety,we will merely only discuss how they affect bodybuilding and steroid usage.


      I hope this topic can help some of you that utilize Antidepressants along with AAS..

      Best regards, Vision
      _____________________________

      SSRI (Selective serotonin reuptake inhibitor)
      Below are the five of the most common and popular SSRI products.



      1. Lexapro
      2. Celexa
      3. Paxil
      4. Zoloft
      5. Prozac


      SNRI (Serotonin-norepinephrine reuptake inhibitor)
      Below are the three of the most common and popular SNRI products.



      1. Effexor
      2. Cymbalta
      3. Pristiq


      Testosterone Levels
      Competitive athletes,sport fitness buffs,serious lifters, and bodybuilder know the importance of testosterone and it’s pivotal role is to the male body/Endocrine system..
      In recent times there have been some numerous studies studies that supporting that SSRI’s in particular can cause reduced testosterone levels,as well as effect female hormonal levels.. Below is a study supporting these notions!

      Antidepressant-Induced Sexual Dysfunction Associated with Low Serum Free
      TestosteroneAlan Jay Cohen, M.D.

      Private Practice and Assistant Clinical Professor of Psychiatry, UCSF

      SUMMARY
      In the course of an evaluation for treatment of antidepressant-induced
      sexual dysfunction (ASD) with a new agent, an unforeseen pattern emerged
      in the pre-treatment laboratory assessment. Free serum testosterone
      levels in both men and women study subjects were found to be below the
      normal ranges in 75 percent of subjects in this small study. There were
      no other consistent laboratory findings that could account for such a
      high percentage correlation.
      Further inquiries into the possible causes for decreased serum
      testosterone and its association with ASD seems warranted.

      INTRODUCTION

      Antidepressant-induced sexual dysfunction (ASD) is a well recognized
      complication of treatment for mood and anxiety disorders, (Gitlin 1997).
      Recent discoveries have helped to provide effective remedies for this
      significant obstacle to patient compliance and successful treatment
      outcome(Cohen 1997, Gitlin 1997, Bartlik 1995). However, no remedy is
      100% effective. In addition, there is no fully satisfactory theory that
      explains the physiologic mechanisms responsible for the varied aspects
      of sexual dysfunction observed. In the course of an
      evaluation of treatment for ASD in a community office-based research
      setting, a striking pattern emerged in the laboratory screening
      protocol. Free testosterone levels were found to be subnormal in 15 of
      20 patients. No other consistent laboratory value nor physical
      examination finding could account for this observation. Causes for
      reduced free testosterone and its effect on sexual function are
      discussed with implications for future research and treatment
      strategies.

      METHODS AND AIMS

      Twenty subjects, ages 35 to 74 years, were evaluated for a double blind
      placebo controlled trial of a dietary supplement combination for the
      treatment of ASD. All of the subjects were using medication for the
      treatment of mood disorder (DSM IV Criteria) included SSRI’s, SNRI’s,
      bupropion, trazodone and mirtazipine. Screening physical exams and
      laboratory studies included CBC, TSH, Prolactin, serum free
      Testosterone, Serum Chemistries, and Urinalysis were done. The Arizona
      Sexual Effects Change Scale (ASECS) was used as part of the clinical
      assessment of ASD. In the course of the evaluation process, low serum
      free testosterone was noted in 15 patients.

      RESULTS
      Twelve men and eight women were evaluated. Eight men had subnormal free
      testosterone levels, two additional men had borderline low levels. Six
      women had subnormal levels of free testosterone. The average age of male
      subjects was 50.5 years. The male ASECS mean score was 20 with a mean
      free Testosterone of 13.5 pg/ml. The laboratory range of free
      Testosterone was 16 – 33 pg/ml. The average age of female subjects was
      39.6 years; female ASECS score was 20, and the mean free Testosterone
      level was 0.8 pg/ml. (normal range 0.8 – 3.0 pg/ml). (Laboratory ranges
      were modified according to standardized norms for age; average free
      testosterone levels decline slightly with increasing age.) Table #1
      summarizes the data on all of the subjects in the study.
      Prolactin levels were above normal in only two subjects (one male, one
      female), both of whom were also found to have below normal levels of
      free testosterone.
      All of the other subjects had normal Prolactin levels. Thyroid
      stimulating hormone was found to be normal in all subjects.
      Table 1.

      Sex Age Medication ASECS score free T (pg./ml.)
      M 35 venlafaxine 16 23.4
      M 36 sertraline 21 5.2 *
      M 43 paroxetine 18 13.5 *
      M 45 venlafaxine 17 16.3 #
      M 46 venlafaxine 20 13.2 *
      M 46 paroxetine/mirtazepine 20 13.4 *
      M 47 citalopram 19 29.0
      M 47 fluoxetine 22 17.6 #
      M 50 sertraline 17 6.2 *
      M 53 nefazodone 25 11.1 *
      M 54 bupropion 21 7.4*
      M 74 venlafaxine 24 5.6 *
      F 20 citalopram 29 1.7
      F 31 venlafaxine 21 0.50*
      F 37 paroxetine 23 0.70 *
      F 41 paroxetine 19 1.5
      F 44 sertraline 16 0.40 *
      F 45 bupropion/trazodone 16 0.50 *
      F 47 fluoxetine 20 0.50*
      F 52 bupropion 16 0.40


      (*denotes subnormal fT levels, # denotes borderline low free T levels)
      ASECS score range is 5-30 , 5 is maximal sexual function, 30 is minimal score.

      DISCUSSION
      This report is the first known documentation of reduced free
      testosterone levels associated with ASD. Prior reports have mentioned
      SSRI-induced prolactin elevations but none have described effects on
      testosterone levels(Amsterdam 1997).
      Certainly, drugs can play a role in decreasing testosterone levels.
      Ketoconazole, megestrol, cimetidine, and spironolactone have all been
      reported to lower testosterone levels(De Coster 1985, Griffin and Wilson
      1998). Methadone and other opiates can suppress testosterone by reducing
      LH levels centrally(Griffin and Wilson 1998) Anticonvulsants have been
      associated with reduced free testosterone although epilepsy itself is also known to exhibit this effect (Herzog, 1992). Carbamazepine may increase metabolic cleaarance of testosterone and reduce LH levels. The P-450 CYP3A3/4 system is involved in the metabolism of testosterone (Griffin and Wilson, 1998). It is possible that antidepressants may be inducing the CYP3A3/4 isoenzyme with resultant enhanced metabolic clearance of testosterone and reduction in free hormone levels. Changes
      in sex hormone binding globulin levels can influence the quantity of
      circulating free testosterone (Griffin and Wilson
      1998). Certain medical conditions; cirrhosis, renal failure, HIV infection etc. have been associated with lower levels of testosterone (Griffin and Wilson, 1998). Even being a sports enthusiast may adversely effect testosterone levels (if the fan is on the losing side) (Bernhardt 1998).
      Studies investigating testosterone levels and mood disorders have shown
      conflicting results (Seidman1998, Levitt, 1998). Levels of testosterone in 12 depressed males were
      compared to age-matched normal controls by Levitt and Joffe in 1988.
      No significant differences were noted between the two
      groups. Clearly, more research is needed to elucidate what role, if any, testosterone plays in the evaluation and treatment of antidepressant-induced sexual dysfunction. Further studies should take into account diurnal variations in hormone level, total and free levels of hormone as well as pre-and post-antidepressant levels. This report isn hindered by the limitations of a small number of subjects, lack of a control group, and no information on the testosterone level of subjects prior to the onset fo antidepressant use. Further studies should also include measurement of total testosterone levels as well as concomitant SHBG levels.

      CONCLUSION

      This is the first description of an association between low testosterone levels and antidepressant-induced sexual dysfunction known to this author. Further research is needed to evaluate this relationship in greater detail. It does open avenues of exploration regarding treatment of ASD utilizing hormone replacement.

      REFERENCES
      1.) Amsterdam J. et al (1997) Breast enlargement during chronic
      antidepressant therapy J Affective Disorders Nov.;46(2):151-156.
      2.) Bartlik B et al (1995) Psychostimulants apparently reverse sexual
      dysfunction secondary to selective serotonin reuptake inhibitors. J Sex
      Marital Ther. 21, (4):264-271.
      3.) Bernhardt PC et al (1998) Testosterone changes during vicarious
      experiences of winning and losing among fans at sporting events. Physiol.
      Behav Aug.;65(1):59-62.
      4.) Cohen AJ and Bartlik B (1998) Ginkgo biloba for
      antidepressant-induced
      sexual dysfunction J Sex Marital Ther Apr-Jun 24:2 139-143.
      5.) De Coster R et al (1985) Effect of a single administration of
      ketoconazole on total and physiologically free plasma testosterone and 17
      beta-oestradiol levels in healthy male volunteers. Eur J Clin Pharmacol
      29(4):489-493.
      6.) Gitlin M. (1997) Sexual side effects of psychotropic medications, in
      Psychiatric Clinics of North America:Annual of Drug Therapy, pg.61-90.
      7.) Griffin J and Wilson J (1998) Disorders of the testes and the male
      reproductive
      tract in :Williams Textbook of Endocrinology 9th ed. W.B. Saunders Co.
      pgs.845-861.
      _8.) Herzog AG (1995) Hormonal changes in epilepsy Epilepsia
      Apr;36(4):323-326.
      9.) Levitt A and Joffe R (1988) Total and free testosterone in depressed
      men Acta Psychiatr Scand Mar;77(3)346-348.
      10.) Sternbach H (1998) Age-associated testosterone decline in men:clinical
      issues for psychiatry Am J Psychiatry Oct, 155:10,1310-1318.
      11.) Seidman S and Rabkin J (1998) Testosterone replacement therapy for
      hypogonadal men with SSRI-refractory depression. J Affect. Disord
      Mar;48(2-3):157-161.
      __________________________________________________ ______________________

      Now at this point is obvious that it should be generalized that an SSRI/SNRI’s can potentially affect Free Test levels/Test!

      Post Cycle TherapyHere is where the facts get interesting..Now if your well rounded/seasoned or even done your research you should be you’re a smart to know/use and understand about running PCT’s, Anti’s and other agents for recovery and assistance..
      So by now I sure hope that your all to familiar with Nolvadex? That’s correct – (Tamoxifen Citrate).

      Nolvadex (Tamox) uses an enzyme ‘CYP2D6′ to convert itself into a more useful form that our bodies can use. Unfortunately many antidepressants also use this same CYP2D6 enzyme, thus you have two medications competing for the same pathway.
      The problem? Antidepressants have priority on the CYP2D6 enzyme therefore can render Nolvadex to be nearly useless, which could cause serious side effects during our PCT such as Gynecomastia. If you’re on an antidepressant and intend on using Nolvadex as your PCT, it’s important for you to know which antidepressants will cause issue and if you’re on an antidepressant that will inhibit Nolvadex from being functional, it’s recommend going with Clomid or Fareston (Toremifene Citrate)instead for your PCT. Below is a list provided by BreastCancer.org showing which SSRI & SNRI are strong to moderate inhibitors and those that are not.

      STRONG INHIBITORS
      Generic Names Brand Names
      Bupropion Wellbutrin
      Fluoxetine Prozac
      Paroxetine Paxil
      Quinidine Cardioquin
      MODERATE INHIBITORS
      Generic Names Brand Names
      Duloxetine Cymbalta
      Sertraline Zoloft
      Diphenhydramine Benadryl
      Thioridazine Mellaril
      Amiodarone Cordarone
      Trazodone Desyrel
      Cimetidine Tagamet
      SSRIS AND SNRIS THAT ARE NOT INHIBITORS
      Generic Names Brand Names
      Venlavaxine Effexor
      Citalopram Celexa
      Escitalopram Lexapro


      Here is some more research on another very popular (repetitively newer) SNRI namedPristiq (Desvenlafaxine) it’s independent of CYP2D6 enzyme therefore shouldn’t negatively interact with Nolvadex.

      Weight Gain
      One of the largest issues in particular with some SSRI’s is unwelcome weight gain, while some bodybuilders would welcome some additional help putting on weight, the majority of this weight comes in the form of fat particularly in the stomach, chest and back areas. The evidence is conclusive that the majority of SSRI’s can and will cause some form of weight gain, studies have shown that SSRI’s can/will reduce a users metabolism to some degree, however as to why SSRI’s slow down a bodies metabolism remains unknown. Even an active healthy adult that eats a balanced diet can experience weight gain. In some cases weight gain in upwards of 30+ lbs is experienced on longer term SSRI usage. SNRI’s on the other hand have a much less likely chance of causing unwelcomed weight gain, in the event SNRI’s cause weight gain it’s typically significantly less than with an SSRI.

      Prolactin Levels
      There is significant medical information that ‘some’ SSRI’s handily increase prolactin levels, prolactin is certainly something users want to keep under control especially on cycle as high prolactin levels can cause an on set of Gyno-puffyness/swelling of breast tissue, lactating breasts is not welcomed by any male! (Get bloods checked,getting a full blood panel pre-cycle/mid/post is crucial)
      Below is a study supporting this-
      Changes in plasma prolactin during SSRI treatment: evidence for a delayed increase in 5-HT neurotransmission.
      Cowen PJ1, Sargent PA.
      Author information

      Abstract
      We studied the effect of the selective serotonin reuptake inhibitor (SSRI), paroxetine, on basal plasma prolactin concentrations in 11 healthy subjects. Subjects were tested before paroxetine, and after 1 and 3 weeks of treatment (20 mg daily). On each test occasion prolactin levels were sampled before and following administration of a placebo capsule, for a total of 4 h. After 3 weeks paroxetine treatment plasma prolactin levels were significantly higher than those seen either pre-treatment or after 1 week of treatment. In contrast, 1 week of paroxetine treatment did not significantly increase prolactin concentrations over pre-treatment values. Plasma concentrations of paroxetine did not differ between 1 and 3 weeks of treatment. The secretion of plasma prolactin is, in part, under the tonic regulation of serotonergic pathways and the present results therefore support animal experimental data suggesting that SSRIs produce a delayed increase in some aspects of brain serotonin neurotransmission.

      Conclusion
      In this discussion, we should have learned what compounds may have an interaction,and what compounds to have concerns with..
      Getting bloods and consulting with your physician,keeping an open honest trust policy will go a long way,and it could avoid any unwated side effect..
      If you suffer from anxiety or depression,you should know the risk with using AAS..
      (Some of these articles have been shared/modified for easier understanding, and research has been add or removed to further support the topic at hand,more information will be added)

      Best regards,
      Vision





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      Fuck me I been taking Paxil... Can I quit taking during PCT or will it be to built up in my system to matter?

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      Excellent info!
      COC RULES: https://brotherhoodofpain.com/anabolic-ster...e-conduct.html

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      If you guys stop taking your anti-depressants, PLEASE consult your doctor. A lot of these horrible drugs to treat depression require weaning, and of course, whatever symptoms that got you on it in the first place may come back with a vengeance.

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