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New Research On T Replacement On The Over 45s

“In clinical trials where testosterone has been used in patients with pre-existing CV conditions, the effect on disease symptoms has typically been either neutral or beneficial,” the researchers wrote. According to results of the review, testosterone treatment significantly improved exercise performance in hypogonadal and eugonadal men with heart failure. Therapy also had no significant effect on serum lipid profiles or C-reactive protein in hypogonadal men with HF and physiologic levels of testosterone; however, therapy did produce small increases in total body mass and reductions in body fat percentage.

Several meta-analyses also linked testosterone treatment with better metabolic parameters, including decreases in fasting plasma glucose, HbA1c, fat mass and plasma triglycerides in patients with type 2 diabetes. In addition, the researchers found that testosterone therapy had no impact or slightly beneficial effects on CV risk factors in hypogonadal men with diabetes or metabolic syndrome. The treatment appeared to improve insulin sensitivity, decreased central adiposity and did not negatively affect inflammation.

An exception was an increase in hematocrit in this patient population using testosterone therapy, the researchers said.

“Although an increase in hematocrit may be of concern in some conditions, patients with [HF] are often anemic; therefore, the effect of testosterone on [hemoglobin] levels may be regarded as beneficial,” the researchers wrote.

In patients with angina or coronary artery disease, hematocrit increased with testosterone treatment, but the therapy had no effect on C-reactive protein, plasminogen activator inhibitor-1 and fibrogen, and antithrombotic factor tissue plasminogen activator.

Although testosterone therapy did not have an effect on LDL and triglyceride levels, the treatment either did not change or considerably reduced total and HDL cholesterol, according to the results. The researchers noted, however, that decreases in total and HDL cholesterol were an inconsistent response among study participants.

Despite these encouraging conclusions, the researchers acknowledged the limitations of the studies analyzed.

“The majority of the randomized, blinded, placebo-controlled clinical trials of testosterone included in this analysis were small and of short duration,” the researchers wrote. “Obviously, outcomes of large, well-designed, prospective trials would be a more compelling proof of the benefit (or otherwise) of testosterone treatment in terms of CV safety.”
I would like to comment . First of all I'm 42 been on TRT for 7 yrs now. It took a long time and lot of trial and error for me and my Endicoligst lot of tweaking with alot of blood work. First my thyroid is messed up due to hereditary from my mother. I was diagnosed with hypothyroidism. Hacimoto disease. On top of tht when I was young and stupid did some pro hormones and didn't cycle off correctly so with tht and thyroid i was screwed i was 35 when this happened. They took the pro hormone off the self it was finna flex rippedback in 2007. My body never recovered so finally after 5 yrs with my family doctor. I decided to go to a encrendoligst. Well there was not tht much reserce on men with thyroid problems cause it rare for a man to have problems. Well any way after plenty of test and trial and error. I finally got all my levels all 16 of them are pretty good and been good for about 2 years now. I go do blood work every 3 months. So this is what my specialist put me on


Test Cyp 200 - 100 mg every 3 days

Hcg 10000iu - 500iu every three days

Astradial 1mcg - 1 every three days

Synthroid 250mg - 1 everyday

Cytomil 50 mcg - 1 every day (half in morning and half after lunch.

So with that said that has me on point pretty much .
So I'm pretty educated on this topic I'm no Doctor but I've done a lot of research because I had to get my manhood back. If I can help anybody hit me up. Thanks for ur time. Will do more research on a mild cycle to push me over the line I diet and lift religiosity. I'm 6'3 260lbs with 24% body fat. It's hard to maintain sometimes because of my thyroid issues. Just have to keep adjusting. It's a nightmare. I figure with the vets on here I can get some good info from there trial and error.


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