from my understanding, and i may be wrong on this, but estrogen level play a bigger role in rather one may get cancer or not. men with bph are not necessarily predisposed to getting prostate cancer. i do not believe that the lower dose of trt would lead to it either. i do believe that each person needs to watch their estrogen levels, and keep them in check. i do not think the doctors will consider checking for this, since in men, estrogen is usually not consider in the overall assessment of their trt problems.